{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:53:12Z","timestamp":1792407192876,"version":"4.4.0"},"reference-count":50,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.3201\/eid2607.200017","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T17:32:08Z","timestamp":1592242328000},"page":"1382-1391","source":"Crossref","is-referenced-by-count":156,"title":["Macrolide-Resistant\n                    <i>Mycoplasma pneumoniae<\/i>\n                    Infections in Pediatric Community-Acquired Pneumonia"],"prefix":"10.3201","volume":"26","author":[{"given":"Yu-Chin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Yun","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu-Hsuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid2607.200017-202006151731-R1","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1056\/NEJMoa1405870","article-title":"Community-acquired pneumonia requiring hospitalization among U.S. children.","volume":"372","author":"Jain","year":"2015","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2607.200017-202006151731-R2","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3345\/kjp.2017.06100","article-title":"The changes of prevalence and etiology of pediatric pneumonia from National Emergency Department Information System in Korea, between 2007 and 2014.","volume":"61","author":"Shin","year":"2018","journal-title":"Korean J Pediatr"},{"key":"key-10.3201\/eid2607.200017-202006151731-R3","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1097\/INF.0b013e318234597c","article-title":"Life-threatening pneumonia caused by macrolide-resistant Mycoplasma pneumoniae.","volume":"31","author":"Hsieh","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"key-10.3201\/eid2607.200017-202006151731-R4","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.anai.2013.01.022","article-title":"Mycoplasma pneumoniae in children with acute and refractory asthma.","volume":"110","author":"Wood","year":"2013","journal-title":"Ann Allergy Asthma Immunol"},{"key":"key-10.3201\/eid2607.200017-202006151731-R5","doi-asserted-by":"publisher","first-page":"974","DOI":"10.3389\/fmicb.2016.00974","article-title":"Mycoplasma pneumoniae: current knowledge on macrolide resistance and treatment.","volume":"7","author":"Pereyre","year":"2016","journal-title":"Front Microbiol"},{"key":"key-10.3201\/eid2607.200017-202006151731-R6","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3389\/fmicb.2016.00329","article-title":"Infection with and carriage of Mycoplasma pneumoniae in children.","volume":"7","author":"Meyer Sauteur","year":"2016","journal-title":"Front Microbiol"},{"key":"key-10.3201\/eid2607.200017-202006151731-R7","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1128\/AAC.01806-13","article-title":"More complications occur in macrolide-resistant than in macrolide-sensitive Mycoplasma pneumoniae pneumonia.","volume":"58","author":"Zhou","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"key-10.3201\/eid2607.200017-202006151731-R8","first-page":"629","article-title":"[Clinical features and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children]","volume":"20","author":"Chen","year":"2018","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"key-10.3201\/eid2607.200017-202006151731-R9","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1002\/ppul.22851","article-title":"Characterization of macrolide resistance of Mycoplasma pneumoniae in children in Shenzhen, China.","volume":"49","author":"Ma","year":"2014","journal-title":"Pediatr Pulmonol"},{"key":"key-10.3201\/eid2607.200017-202006151731-R10","first-page":"1213","article-title":"Clinical characteristics of children with macrolide-resistant Mycoplasma pneumoniae pneumonia","volume":"16","author":"Xin","year":"2010","journal-title":"J Appl Clin Pediatr"},{"key":"key-10.3201\/eid2607.200017-202006151731-R11","doi-asserted-by":"publisher","first-page":"749","DOI":"10.2174\/1386207322666190111112946","article-title":"Clinical characteristics and antibiotic resistance of Mycoplasma pneumoniae pneumonia in hospitalized Chinese children.","volume":"21","author":"Yuan","year":"2018","journal-title":"Comb Chem High Throughput Screen"},{"key":"key-10.3201\/eid2607.200017-202006151731-R12","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jmii.2014.11.003","article-title":"Severe macrolide-resistant Mycoplasma pneumoniae pneumonia associated with macrolide failure.","volume":"49","author":"Cheong","year":"2016","journal-title":"J Microbiol Immunol Infect"},{"key":"key-10.3201\/eid2607.200017-202006151731-R13","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1097\/INF.0b013e3182a25c71","article-title":"Rapid defervescence after doxycycline treatment of macrolide-resistant Mycoplasma pneumoniae-associated community-acquired pneumonia in children.","volume":"32","author":"Lung","year":"2013","journal-title":"Pediatr Infect Dis J"},{"key":"key-10.3201\/eid2607.200017-202006151731-R14","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1128\/JCM.02840-12","article-title":"Clinical relevance of Mycoplasma pneumoniae macrolide resistance in children.","volume":"51","author":"Cardinale","year":"2013","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid2607.200017-202006151731-R15","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/jgf2.201","article-title":"Clinical features and seasonal variations in the prevalence of macrolide-resistant Mycoplasma pneumoniae.","volume":"19","author":"Akashi","year":"2018","journal-title":"J Gen Fam Med"},{"key":"key-10.3201\/eid2607.200017-202006151731-R16","doi-asserted-by":"publisher","first-page":"e0173635","DOI":"10.1371\/journal.pone.0173635","article-title":"Therapeutic efficacy of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae pneumonia in pediatric patients.","volume":"12","author":"Ishiguro","year":"2017","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2607.200017-202006151731-R17","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1111\/j.1440-1843.2011.02102.x","article-title":"Clinical efficacy of macrolide antibiotics against genetically determined macrolide-resistant Mycoplasma pneumoniae pneumonia in paediatric patients.","volume":"17","author":"Kawai","year":"2012","journal-title":"Respirology"},{"key":"key-10.3201\/eid2607.200017-202006151731-R18","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1128\/AAC.00048-13","article-title":"Therapeutic efficacy of macrolides, minocycline, and tosufloxacin against macrolide-resistant Mycoplasma pneumoniae pneumonia in pediatric patients.","volume":"57","author":"Kawai","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"key-10.3201\/eid2607.200017-202006151731-R19","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1007\/s10156-009-0715-7","article-title":"A comparative clinical study of macrolide-sensitive and macrolide-resistant Mycoplasma pneumoniae infections in pediatric patients.","volume":"15","author":"Matsubara","year":"2009","journal-title":"J Infect Chemother"},{"key":"key-10.3201\/eid2607.200017-202006151731-R20","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/1471-2334-12-126","article-title":"Macrolide-resistant Mycoplasma pneumoniae in adolescents with community-acquired pneumonia.","volume":"12","author":"Miyashita","year":"2012","journal-title":"BMC Infect Dis"},{"key":"key-10.3201\/eid2607.200017-202006151731-R21","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1093\/cid\/cis784","article-title":"Rapid effectiveness of minocycline or doxycycline against macrolide-resistant Mycoplasma pneumoniae infection in a 2011 outbreak among Japanese children.","volume":"55","author":"Okada","year":"2012","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid2607.200017-202006151731-R22","doi-asserted-by":"publisher","first-page":"340","DOI":"10.4168\/aair.2017.9.4.340","article-title":"Macrolide resistance and its impacts on M. pneumoniae pneumonia in children: comparison of two recent epidemics in Korea.","volume":"9","author":"Kim","year":"2017","journal-title":"Allergy Asthma Immunol Res"},{"key":"key-10.3201\/eid2607.200017-202006151731-R23","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.3346\/jkms.2017.32.10.1642","article-title":"Clinical characteristics of macrolide-resistant Mycoplasma pneumoniae from children in Jeju.","volume":"32","author":"Kim","year":"2017","journal-title":"J Korean Med Sci"},{"key":"key-10.3201\/eid2607.200017-202006151731-R24","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3345\/kjp.2017.60.5.151","article-title":"Prevalence and clinical manifestations of macrolide resistant Mycoplasma pneumoniae pneumonia in Korean children.","volume":"60","author":"Lee","year":"2017","journal-title":"Korean J Pediatr"},{"key":"key-10.3201\/eid2607.200017-202006151731-R25","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3345\/kjp.2014.57.4.186","article-title":"Predictive value of C-reactive protein in response to macrolides in children with macrolide-resistant Mycoplasma pneumoniae pneumonia.","volume":"57","author":"Seo","year":"2014","journal-title":"Korean J Pediatr"},{"key":"key-10.3201\/eid2607.200017-202006151731-R26","doi-asserted-by":"publisher","first-page":"6393","DOI":"10.1128\/AAC.01421-12","article-title":"Differences in the frequency of 23S rRNA gene mutations in Mycoplasma pneumoniae between children and adults with community-acquired pneumonia: clinical impact of mutations conferring macrolide resistance.","volume":"56","author":"Yoo","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"key-10.3201\/eid2607.200017-202006151731-R27","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1186\/s12879-017-2500-z","article-title":"Radiologic findings as a determinant and no effect of macrolide resistance on clinical course of Mycoplasma pneumoniae pneumonia.","volume":"17","author":"Yoon","year":"2017","journal-title":"BMC Infect Dis"},{"key":"key-10.3201\/eid2607.200017-202006151731-R28","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1007\/s10156-012-0523-3","article-title":"Macrolide-resistant Mycoplasma pneumoniae in children in Taiwan.","volume":"19","author":"Wu","year":"2013","journal-title":"J Infect Chemother"},{"key":"key-10.3201\/eid2607.200017-202006151731-R29","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1002\/ppul.22706","article-title":"Epidemiology and clinical manifestations of children with macrolide-resistant Mycoplasma pneumoniae pneumonia in Taiwan.","volume":"48","author":"Wu","year":"2013","journal-title":"Pediatr Pulmonol"},{"key":"key-10.3201\/eid2607.200017-202006151731-R30","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jmii.2018.09.009","article-title":"Mycoplasma pneumoniae in pediatric patients: Do macrolide-resistance and\/or delayed treatment matter?","volume":"52","author":"Yang","year":"2019","journal-title":"J Microbiol Immunol Infect"},{"key":"key-10.3201\/eid2607.200017-202006151731-R31","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.3201\/eid2408.180081","article-title":"Clonal expansion of macrolide-resistant sequence type 3 Mycoplasma pneumoniae, South Korea.","volume":"24","author":"Lee","year":"2018","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2607.200017-202006151731-R32","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.3201\/eid2310.170106","article-title":"Macrolide-resistant Mycoplasma pneumoniae infection, Japan, 2008\u20132015.","volume":"23","author":"Tanaka","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2607.200017-202006151731-R33","doi-asserted-by":"publisher","first-page":"e0209938","DOI":"10.1371\/journal.pone.0209938","article-title":"Genetic characterization of Mycoplasma pneumoniae isolated in Osaka between 2011 and 2017: Decreased detection rate of macrolide-resistance and increase of p1 gene type 2 lineage strains.","volume":"14","author":"Katsukawa","year":"2019","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2607.200017-202006151731-R34","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1099\/jmm.0.000969","article-title":"Polyclonal spread of multiple genotypes of Mycoplasma pneumoniae in semi-closed settings in Yamagata, Japan.","volume":"68","author":"Suzuki","year":"2019","journal-title":"J Med Microbiol"},{"key":"key-10.3201\/eid2607.200017-202006151731-R35","doi-asserted-by":"publisher","first-page":"e38585","DOI":"10.1371\/journal.pone.0038585","article-title":"The spread of Mycoplasma pneumoniae is polyclonal in both an endemic setting in France and in an epidemic setting in Israel.","volume":"7","author":"Pereyre","year":"2012","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2607.200017-202006151731-R36","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.3201\/eid2410.171194","article-title":"Multilocus sequence typing of Mycoplasma pneumoniae, Japan, 2002\u20132016.","volume":"24","author":"Ando","year":"2018","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2607.200017-202006151731-R37","doi-asserted-by":"publisher","first-page":"e0137354","DOI":"10.1371\/journal.pone.0137354","article-title":"Comparative \u201c-omics\u201d in Mycoplasma pneumoniae clinical isolates reveals key virulence factors.","volume":"10","author":"Lluch-Senar","year":"2015","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2607.200017-202006151731-R38","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1128\/AAC.02060-12","article-title":"Surveillance of macrolide-resistant Mycoplasma pneumoniae in Beijing, China, from 2008 to 2012.","volume":"57","author":"Zhao","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"key-10.3201\/eid2607.200017-202006151731-R39","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.3201\/eid1909.121466","article-title":"Macrolide-resistant Mycoplasma pneumoniae in humans, Ontario, Canada, 2010-2011.","volume":"19","author":"Eshaghi","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2607.200017-202006151731-R40","doi-asserted-by":"publisher","first-page":"726","DOI":"10.3390\/jcm8050726","article-title":"Early corticosteroid therapy for Mycoplasma pneumoniae pneumonia irrespective of used antibiotics in children.","volume":"8","author":"Yang","year":"2019","journal-title":"J Clin Med"},{"key":"key-10.3201\/eid2607.200017-202006151731-R41","doi-asserted-by":"publisher","first-page":"800","DOI":"10.3389\/fmicb.2016.00800","article-title":"Clinical features of severe or fatal Mycoplasma pneumoniae pneumonia.","volume":"7","author":"Izumikawa","year":"2016","journal-title":"Front Microbiol"},{"key":"key-10.3201\/eid2607.200017-202006151731-R42","doi-asserted-by":"publisher","first-page":"693","DOI":"10.3389\/fmicb.2016.00693","article-title":"Epidemiology of Mycoplasma pneumoniae infections in Japan and therapeutic strategies for macrolide-resistant M. pneumoniae.","volume":"7","author":"Yamazaki","year":"2016","journal-title":"Front Microbiol"},{"key":"key-10.3201\/eid2607.200017-202006151731-R43","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.jmii.2018.11.004","article-title":"Recommendations and guidelines for the treatment of pneumonia in Taiwan.","volume":"52","author":"Chou","year":"2019","journal-title":"J Microbiol Immunol Infect"},{"key":"key-10.3201\/eid2607.200017-202006151731-R44","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1093\/tropej\/fmu022","article-title":"Early treatment with corticosteroids in patients with Mycoplasma pneumoniae pneumonia: a randomized clinical trial.","volume":"60","author":"Huang","year":"2014","journal-title":"J Trop Pediatr"},{"key":"key-10.3201\/eid2607.200017-202006151731-R45","doi-asserted-by":"publisher","first-page":"726","DOI":"10.3390\/jcm8050726","article-title":"Early corticosteroid therapy for Mycoplasma pneumoniae pneumonia irrespective of used antibiotics in children.","volume":"8","author":"Yang","year":"2019","journal-title":"J Clin Med"},{"key":"key-10.3201\/eid2607.200017-202006151731-R46","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.resinv.2017.11.005","article-title":"Recent trends in practice patterns and impact of corticosteroid use on pediatric Mycoplasma pneumoniae-related respiratory infections.","volume":"56","author":"Okubo","year":"2018","journal-title":"Respir Investig"},{"key":"key-10.3201\/eid2607.200017-202006151731-R47","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1093\/fampra\/cmy094","article-title":"Pattern of antibiotic prescriptions for outpatients with acute respiratory tract infections in Japan, 2013-15: a retrospective observational study.","volume":"36","author":"Teratani","year":"2019","journal-title":"Fam Pract"},{"key":"key-10.3201\/eid2607.200017-202006151731-R48","doi-asserted-by":"publisher","first-page":"149","DOI":"10.7883\/yoken.JJID.2018.374","article-title":"Targets for optimizing oral antibiotic prescriptions for pediatric outpatients in Japan.","volume":"72","author":"Uda","year":"2019","journal-title":"Jpn J Infect Dis"},{"key":"key-10.3201\/eid2607.200017-202006151731-R49","doi-asserted-by":"publisher","first-page":"e0177435","DOI":"10.1371\/journal.pone.0177435","article-title":"Antibiotic use in South Korea from 2007 to 2014: A health insurance database-generated time series analysis.","volume":"12","author":"Park","year":"2017","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2607.200017-202006151731-R50","doi-asserted-by":"publisher","first-page":"jiaa062","DOI":"10.1093\/infdis\/jiaa062","article-title":"Circulating antibody-secreting cell response during Mycoplasma pneumoniae childhood pneumonia.","author":"Meyer Sauteur","year":"2020","journal-title":"J Infect Dis"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/26\/7\/20-0017_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T12:34:22Z","timestamp":1732970062000},"score":1,"resource":{"primary":{"URL":"http:\/\/wwwnc.cdc.gov\/eid\/article\/26\/7\/20-0017_article.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"URL":"https:\/\/doi.org\/10.3201\/eid2607.200017","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}