{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:08:15Z","timestamp":1790676495007,"version":"4.1.0"},"reference-count":46,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.3201\/eid2702.191795","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T21:12:46Z","timestamp":1609881166000},"page":"430-442","source":"Crossref","is-referenced-by-count":37,"title":["Plasma MicroRNA Profiling of\n                    <i>Plasmodium falciparum<\/i>\n                    Biomass and Association with Severity of Malaria Disease"],"prefix":"10.3201","volume":"27","author":[{"given":"Himanshu","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Sitoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosauro","family":"Varo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Cister\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lola","family":"Madrid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inocencia","family":"Cuamba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfons","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Marti\u00e1\u00f1ez-Vendrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Barrios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Pantano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Brimacombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariona","family":"Bustamante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quique","family":"Bassat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Mayor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid2702.191795-202101221301-R1","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1016\/S0140-6736(10)61924-1","article-title":"Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial.","volume":"376","author":"Dondorp","year":"2010","journal-title":"Lancet"},{"key":"key-10.3201\/eid2702.191795-202101221301-R2","doi-asserted-by":"publisher","first-page":"7620","DOI":"10.1073\/pnas.95.13.7620","article-title":"Estimating sequestered parasite population dynamics in cerebral malaria.","volume":"95","author":"Gravenor","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.3201\/eid2702.191795-202101221301-R3","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/415673a","article-title":"The pathogenic basis of malaria.","volume":"415","author":"Miller","year":"2002","journal-title":"Nature"},{"key":"key-10.3201\/eid2702.191795-202101221301-R4","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1016\/j.ajpath.2011.01.016","article-title":"The neuropathology of fatal cerebral malaria in malawian children.","volume":"178","author":"Dorovini-Zis","year":"2011","journal-title":"Am J Pathol"},{"key":"key-10.3201\/eid2702.191795-202101221301-R5","doi-asserted-by":"publisher","first-page":"259","DOI":"10.4269\/ajtmh.1992.47.259","article-title":"Pathology of falciparum malaria in Vietnam.","volume":"47","author":"Nagatake","year":"1992","journal-title":"Am J Trop Med Hyg"},{"key":"key-10.3201\/eid2702.191795-202101221301-R6","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3389\/fcimb.2014.00104","article-title":"The systemic pathology of cerebral malaria in African children.","volume":"4","author":"Milner","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"key":"key-10.3201\/eid2702.191795-202101221301-R7","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1093\/infdis\/jit116","article-title":"Lethal malaria: Marchiafava and Bignami were right.","volume":"208","author":"White","year":"2013","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2702.191795-202101221301-R8","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1017\/S1462399409001082","article-title":"Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications.","volume":"11","author":"Rowe","year":"2009","journal-title":"Expert Rev Mol Med"},{"key":"key-10.3201\/eid2702.191795-202101221301-R9","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nature12216","article-title":"Severe malaria is associated with parasite binding to endothelial protein C receptor.","volume":"498","author":"Turner","year":"2013","journal-title":"Nature"},{"key":"key-10.3201\/eid2702.191795-202101221301-R10","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/imr.12807","article-title":"Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it.","volume":"293","author":"Jensen","year":"2020","journal-title":"Immunol Rev"},{"key":"key-10.3201\/eid2702.191795-202101221301-R11","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3389\/fcimb.2015.00075","article-title":"Pathogenesis of cerebral malaria: new diagnostic tools, biomarkers, and therapeutic approaches.","volume":"5","author":"Sahu","year":"2015","journal-title":"Front Cell Infect Microbiol"},{"key":"key-10.3201\/eid2702.191795-202101221301-R12","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1186\/1475-2875-13-279","article-title":"Chitinase 3-like 1 is induced by Plasmodium falciparum malaria and predicts outcome of cerebral malaria and severe malarial anaemia in a case-control study of African children.","volume":"13","author":"Erdman","year":"2014","journal-title":"Malar J"},{"key":"key-10.3201\/eid2702.191795-202101221301-R13","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1155\/2011\/345706","article-title":"Potential serological biomarkers of cerebral malaria.","volume":"31","author":"Lucchi","year":"2011","journal-title":"Dis Markers"},{"key":"key-10.3201\/eid2702.191795-202101221301-R14","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1186\/s12936-016-1378-3","article-title":"Plasma levels of eight different mediators and their potential as biomarkers of various clinical malaria conditions in African children.","volume":"15","author":"Tahar","year":"2016","journal-title":"Malar J"},{"key":"key-10.3201\/eid2702.191795-202101221301-R15","doi-asserted-by":"publisher","first-page":"e204","DOI":"10.1371\/journal.pmed.0020204","article-title":"Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2.","volume":"2","author":"Dondorp","year":"2005","journal-title":"PLoS Med"},{"key":"key-10.3201\/eid2702.191795-202101221301-R16","doi-asserted-by":"publisher","first-page":"e1001297","DOI":"10.1371\/journal.pmed.1001297","article-title":"Diagnosing severe falciparum malaria in parasitaemic African children: a prospective evaluation of plasma PfHRP2 measurement.","volume":"9","author":"Hendriksen","year":"2012","journal-title":"PLoS Med"},{"key":"key-10.3201\/eid2702.191795-202101221301-R17","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nrclinonc.2011.76","article-title":"MicroRNAs in body fluids\u2014the mix of hormones and biomarkers.","volume":"8","author":"Cortez","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"key":"key-10.3201\/eid2702.191795-202101221301-R18","doi-asserted-by":"publisher","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection.","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.3201\/eid2702.191795-202101221301-R19","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.pt.2011.07.001","article-title":"Apicomplexan parasites and subversion of the host cell microRNA pathway.","volume":"27","author":"Hakimi","year":"2011","journal-title":"Trends Parasitol"},{"key":"key-10.3201\/eid2702.191795-202101221301-R20","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1128\/IAI.01136-10","article-title":"Differential microRNA expression in experimental cerebral and noncerebral malaria.","volume":"79","author":"El-Assaad","year":"2011","journal-title":"Infect Immun"},{"key":"key-10.3201\/eid2702.191795-202101221301-R21","doi-asserted-by":"publisher","first-page":"e0005365","DOI":"10.1371\/journal.pntd.0005365","article-title":"Plasmodium vivax gametocytes in the bone marrow of an acute malaria patient and changes in the erythroid miRNA profile.","volume":"11","author":"Baro","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"key-10.3201\/eid2702.191795-202101221301-R22","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1475-2875-7-47","article-title":"No miRNA were found in Plasmodium and the ones identified in erythrocytes could not be correlated with infection.","volume":"7","author":"Xue","year":"2008","journal-title":"Malar J"},{"key":"key-10.3201\/eid2702.191795-202101221301-R23","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12936-016-1222-9","article-title":"Tying malaria and microRNAs: from the biology to future diagnostic perspectives.","volume":"15","author":"Rubio","year":"2016","journal-title":"Malar J"},{"key":"key-10.3201\/eid2702.191795-202101221301-R24","unstructured":"StatsTutor. Spearman\u2019s correlation. 2011 [cited 2020 Nov 23]. http:\/\/www.statstutor.ac.uk\/resources\/uploaded\/spearmans.pdf"},{"key":"key-10.3201\/eid2702.191795-202101221301-R25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1475-2875-8-9","article-title":"Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women.","volume":"8","author":"Mayor","year":"2009","journal-title":"Malar J"},{"key":"key-10.3201\/eid2702.191795-202101221301-R26","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1128\/JCM.00565-14","article-title":"A quality control program within a clinical trial Consortium for PCR protocols to detect Plasmodium species.","volume":"52","author":"Taylor","year":"2014","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid2702.191795-202101221301-R27","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1158\/1940-6207.CAPR-09-0094","article-title":"MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease.","volume":"2","author":"Wang","year":"2009","journal-title":"Cancer Prev Res (Phila)"},{"key":"key-10.3201\/eid2702.191795-202101221301-R28","doi-asserted-by":"publisher","first-page":"e0193527","DOI":"10.1371\/journal.pone.0193527","article-title":"Circulating miRNAs, isomiRs and small RNA clusters in human plasma and breast milk.","volume":"13","author":"Rubio","year":"2018","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2702.191795-202101221301-R29","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1093\/nar\/gkp1127","article-title":"SeqBuster, a bioinformatic tool for the processing and analysis of small RNAs datasets, reveals ubiquitous miRNA modifications in human embryonic cells.","volume":"38","author":"Pantano","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"key-10.3201\/eid2702.191795-202101221301-R30","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"key-10.3201\/eid2702.191795-202101221301-R31","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1093\/bib\/bbv056","article-title":"Normalization of circulating microRNA expression data obtained by quantitative real-time RT-PCR.","volume":"17","author":"Marabita","year":"2016","journal-title":"Brief Bioinform"},{"key":"key-10.3201\/eid2702.191795-202101221301-R32","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1093\/bioinformatics\/btr527","article-title":"A non-biased framework for the annotation and classification of the non-miRNA small RNA transcriptome.","volume":"27","author":"Pantano","year":"2011","journal-title":"Bioinformatics"},{"key":"key-10.3201\/eid2702.191795-202101221301-R33","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3389\/fgene.2013.00094","article-title":"The impact of hemolysis on cell-free microRNA biomarkers.","volume":"4","author":"Kirschner","year":"2013","journal-title":"Front Genet"},{"key":"key-10.3201\/eid2702.191795-202101221301-R34","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.chom.2012.06.007","article-title":"Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance.","volume":"12","author":"LaMonte","year":"2012","journal-title":"Cell Host Microbe"},{"key":"key-10.3201\/eid2702.191795-202101221301-R35","doi-asserted-by":"publisher","first-page":"e2360","DOI":"10.1371\/journal.pone.0002360","article-title":"The genomic analysis of erythrocyte microRNA expression in sickle cell diseases.","volume":"3","author":"Chen","year":"2008","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2702.191795-202101221301-R36","doi-asserted-by":"publisher","first-page":"5185","DOI":"10.1016\/j.febslet.2006.08.063","article-title":"Analysis of short RNAs in the malaria parasite and its red blood cell host.","volume":"580","author":"Rathjen","year":"2006","journal-title":"FEBS Lett"},{"key":"key-10.3201\/eid2702.191795-202101221301-R37","doi-asserted-by":"publisher","first-page":"3865","DOI":"10.1093\/nar\/gkw116","article-title":"Distribution of miRNA expression across human tissues.","volume":"44","author":"Ludwig","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"key-10.3201\/eid2702.191795-202101221301-R38","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.jad.2016.04.021","article-title":"Peripheral whole blood microRNA alterations in major depression and bipolar disorder.","volume":"200","author":"Maffioletti","year":"2016","journal-title":"J Affect Disord"},{"key":"key-10.3201\/eid2702.191795-202101221301-R39","doi-asserted-by":"publisher","first-page":"e19422","DOI":"10.1371\/journal.pone.0019422","article-title":"Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.","volume":"6","author":"Mayor","year":"2011","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2702.191795-202101221301-R40","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.anl.2018.05.005","article-title":"MicroRNA-4497 functions as a tumor suppressor in laryngeal squamous cell carcinoma via negatively modulation the GBX2.","volume":"46","author":"Chen","year":"2019","journal-title":"Auris Nasus Larynx"},{"key":"key-10.3201\/eid2702.191795-202101221301-R41","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1016\/S1472-9792(13)70010-6","article-title":"Differential expression of miRNAs by macrophages infected with virulent and avirulent Mycobacterium tuberculosis.","volume":"93","author":"Das","year":"2013","journal-title":"Tuberculosis (Edinb)"},{"key":"key-10.3201\/eid2702.191795-202101221301-R42","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12867-016-0057-9","article-title":"What is normal? Next generation sequencing-driven analysis of the human circulating miRNAOme.","volume":"17","author":"Tonge","year":"2016","journal-title":"BMC Mol Biol"},{"key":"key-10.3201\/eid2702.191795-202101221301-R43","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1093\/bioinformatics\/btx019","article-title":"miRmine: a database of human miRNA expression profiles.","volume":"33","author":"Panwar","year":"2017","journal-title":"Bioinformatics"},{"key":"key-10.3201\/eid2702.191795-202101221301-R44","doi-asserted-by":"publisher","first-page":"14","DOI":"10.2174\/2211536611302010003","article-title":"Isolation of secreted microRNAs (miRNAs) from cell-conditioned media.","volume":"2","author":"Glynn","year":"2013","journal-title":"MicroRNA"},{"key":"key-10.3201\/eid2702.191795-202101221301-R45","doi-asserted-by":"publisher","first-page":"e0167969","DOI":"10.1371\/journal.pone.0167969","article-title":"Stability of circulating blood-based microRNAs\u2014pre-analytic methodological considerations.","volume":"12","author":"Glinge","year":"2017","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2702.191795-202101221301-R46","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.jmoldx.2013.07.005","article-title":"Quantification of circulating miRNAs in plasma: effect of preanalytical and analytical parameters on their isolation and stability.","volume":"15","author":"Sourvinou","year":"2013","journal-title":"J Mol Diagn"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/27\/2\/19-1795_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T12:49:56Z","timestamp":1732970996000},"score":1,"resource":{"primary":{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/27\/2\/19-1795_article.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"URL":"https:\/\/doi.org\/10.3201\/eid2702.191795","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.07.31.20165712","asserted-by":"object"}]},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}