{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T22:55:50Z","timestamp":1786575350973,"version":"build-2736575974"},"reference-count":49,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.3201\/eid2702.203729","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T02:48:36Z","timestamp":1609901316000},"page":"385-395","source":"Crossref","is-referenced-by-count":42,"title":["Symptom Profiles and Progression in Hospitalized and Nonhospitalized Patients with Coronavirus Disease, Colorado, USA, 2020"],"prefix":"10.3201","volume":"27","author":[{"given":"Grace M.","family":"Vahey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen E.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey W.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline E.","family":"Tate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire M.","family":"Midgley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie E.","family":"Killerby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breanna","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel K.","family":"Herlihy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha B.","family":"Alden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Erin","family":"Staples","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Colorado Investigation Team2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1822","reference":[{"key":"#cr-split#-key-10.3201\/eid2702.203729-202101221220-R1.1","unstructured":"World Health Organization. Coronavirus disease 2019 (COVID-19) situation report-1. Geneva: The Organization"},{"key":"#cr-split#-key-10.3201\/eid2702.203729-202101221220-R1.2","unstructured":"2020 [cited 2020 Jun 11]. https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20200121-sitrep-1-2019-ncov.pdf"},{"key":"key-10.3201\/eid2702.203729-202101221220-R2","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","article-title":"The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2.","volume":"5","author":"Coronaviridae Study Group of the International Committee on Taxonomy of Viruses","year":"2020","journal-title":"Nat Microbiol"},{"key":"key-10.3201\/eid2702.203729-202101221220-R3","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1056\/NEJMoa2001191","article-title":"Washington State 2019-nCoV Case Investigation Team. First case of 2019 novel coronavirus in the United States.","volume":"382","author":"Holshue","year":"2020","journal-title":"N Engl J Med"},{"key":"#cr-split#-key-10.3201\/eid2702.203729-202101221220-R4.1","unstructured":"World Health Organization. Coronavirus disease 2019 (COVID-19) situation report-11. Geneva: The Organization"},{"key":"#cr-split#-key-10.3201\/eid2702.203729-202101221220-R4.2","unstructured":"2020 [cited 2020 Jun 11]. https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20200131-sitrep-11-ncov.pdf"},{"key":"#cr-split#-key-10.3201\/eid2702.203729-202101221220-R5.1","unstructured":"World Health Organization. Coronavirus disease 2019 (COVID-19) situation report-51. Geneva: The Organization"},{"key":"#cr-split#-key-10.3201\/eid2702.203729-202101221220-R5.2","unstructured":"2020 [cited 2020 Jun 11]. https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20200311-sitrep-51-covid-19.pdf"},{"key":"key-10.3201\/eid2702.203729-202101221220-R6","unstructured":"Centers for Disease Control and Prevention. Coronavirus disease 2019 (COVID-19). United States COVID-19 cases and deaths by state [cited 2020 Dec 04]. https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/cases-updates\/cases-in-us.html"},{"key":"key-10.3201\/eid2702.203729-202101221220-R7","doi-asserted-by":"publisher","first-page":"458","DOI":"10.15585\/mmwr.mm6915e3","article-title":"Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019\u2014COVID-NET, 14 states, March 1\u201330, 2020.","volume":"69","author":"Garg","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.3201\/eid2702.203729-202101221220-R8","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1056\/NEJMc2010419","article-title":"Clinical characteristics of Covid-19 in New York City.","volume":"382","author":"Goyal","year":"2020","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2702.203729-202101221220-R9","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical Characteristics of Coronavirus Disease 2019 in China.","volume":"382","author":"Guan","year":"2020","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2702.203729-202101221220-R10","unstructured":"Centers for Disease Control and Prevention. Coronavirus disease 2019 (COVID-19). Symptoms of coronavirus [cited 2020 May 28]. https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/symptoms-testing\/symptoms.html"},{"key":"key-10.3201\/eid2702.203729-202101221220-R11","article-title":"Acute-onset smell and taste disorders in the context of COVID-19: a pilot multicentre polymerase chain reaction based case-control study.","author":"Beltr\u00e1n-Corbellini","year":"2020","journal-title":"Eur J Neurol"},{"key":"key-10.3201\/eid2702.203729-202101221220-R12","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1001\/jama.2020.2648","article-title":"Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72,314 cases from the Chinese Center for Disease Control and Prevention.","volume":"323","author":"Wu","year":"2020","journal-title":"JAMA"},{"key":"key-10.3201\/eid2702.203729-202101221220-R13","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support.","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"key-10.3201\/eid2702.203729-202101221220-R14","doi-asserted-by":"publisher","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: Building an international community of software platform partners.","volume":"95","author":"Harris","year":"2019","journal-title":"J Biomed Inform"},{"key":"key-10.3201\/eid2702.203729-202101221220-R15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1751-0473-3-17","article-title":"Purposeful selection of variables in logistic regression.","volume":"3","author":"Bursac","year":"2008","journal-title":"Source Code Biol Med"},{"key":"key-10.3201\/eid2702.203729-202101221220-R16","unstructured":"R Core Team. R: a language and environment for statistical computing. Version 3.6.3 [cited 2020 Jun 15]. http:\/\/www.R-project.org"},{"key":"key-10.3201\/eid2702.203729-202101221220-R17","doi-asserted-by":"publisher","first-page":"904","DOI":"10.15585\/mmwr.mm6928a2","article-title":"Symptom profiles of a convenience sample of patients with COVID-19-United States, January\u2013April 2020.","volume":"69","author":"Burke","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.3201\/eid2702.203729-202101221220-R18","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jinf.2020.03.004","article-title":"Clinical progression of patients with COVID-19 in Shanghai, China.","volume":"80","author":"Chen","year":"2020","journal-title":"J Infect"},{"key":"key-10.3201\/eid2702.203729-202101221220-R19","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1093\/cid\/ciaa330","article-title":"Self-reported olfactory and taste disorders in patients with severe acute respiratory coronavirus 2 infection: a cross-sectional study.","volume":"71","author":"Giacomelli","year":"2020","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid2702.203729-202101221220-R20","unstructured":"Gaythorpe K, Imai N, Cuomo-Dannenburg G, Baguelin M, Bhatia S, Boonyasiri A,  Report 8: symptom progression of COVID-19. London: Imperial College London; 2020 [cited 2020 Jul 2]. http:\/\/hdl.handle.net\/10044\/1\/77344"},{"key":"key-10.3201\/eid2702.203729-202101221220-R21","doi-asserted-by":"publisher","first-page":"e0234765","DOI":"10.1371\/journal.pone.0234765","article-title":"The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries.","volume":"15","author":"Grant","year":"2020","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2702.203729-202101221220-R22","doi-asserted-by":"publisher","first-page":"ciaa1072","DOI":"10.1093\/cid\/ciaa1072","article-title":"A prospective cohort study in non-hospitalized household contacts with SARS-CoV-2 infection: symptom profiles and symptom change over time.","author":"Yousaf","year":"2020","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid2702.203729-202101221220-R23","doi-asserted-by":"publisher","first-page":"e21866","DOI":"10.2196\/21866","article-title":"Self-reported symptoms of SARS-CoV-2 infection in a nonhospitalized population in Italy: cross-sectional study of the EPICOVID19 web-based survey.","volume":"6","author":"Adorni","year":"2020","journal-title":"JMIR Public Health Surveill"},{"key":"key-10.3201\/eid2702.203729-202101221220-R24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s42399-020-00453-3","article-title":"Non-hospitalized adults with COVID-19 differ noticeably from hospitalized adults in their demographic, clinical, and social characteristics.","volume":"2","author":"Bergquist","year":"2020","journal-title":"SN Compr Clin Med"},{"key":"key-10.3201\/eid2702.203729-202101221220-R25","first-page":"501","article-title":"Sex differences in the frequency of gastrointestinal symptoms and olfactory or taste disorders in 1942 nonhospitalized patients with coronavirus disease 2019 (COVID-19).","volume":"130","author":"Sierpi\u0144ski","year":"2020","journal-title":"Pol Arch Intern Med"},{"key":"key-10.3201\/eid2702.203729-202101221220-R26","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1001\/jama.2020.6771","article-title":"Alterations in smell or taste in mildly symptomatic outpatients with SARS-CoV-2 infection.","volume":"323","author":"Spinato","year":"2020","journal-title":"JAMA"},{"key":"key-10.3201\/eid2702.203729-202101221220-R27","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1053\/j.gastro.2020.04.017","article-title":"Gastrointestinal symptoms and COVID-19: case-control study from the United States.","volume":"159","author":"Nobel","year":"2020","journal-title":"Gastroenterology"},{"key":"key-10.3201\/eid2702.203729-202101221220-R28","doi-asserted-by":"publisher","first-page":"766","DOI":"10.14309\/ajg.0000000000000620","article-title":"Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study.","volume":"115","author":"Pan","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"key-10.3201\/eid2702.203729-202101221220-R29","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00038-020-01390-7","article-title":"Predictive symptoms and comorbidities for severe COVID-19 and intensive care unit admission: a systematic review and meta-analysis.","volume":"65","author":"Jain","year":"2020","journal-title":"Int J Public Health"},{"key":"key-10.3201\/eid2702.203729-202101221220-R30","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/joim.13089","article-title":"Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019.","volume":"288","author":"Lechien","year":"2020","journal-title":"J Intern Med"},{"key":"key-10.3201\/eid2702.203729-202101221220-R31","doi-asserted-by":"publisher","first-page":"948.e1","DOI":"10.1016\/j.cmi.2020.04.040","article-title":"Clinical characteristics of asymptomatic and symptomatic patients with mild COVID-19.","volume":"26","author":"Kim","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"key-10.3201\/eid2702.203729-202101221220-R32","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/S0140-6736(20)30374-3","article-title":"COVID-19: what is next for public health?","volume":"395","author":"Heymann","year":"2020","journal-title":"Lancet"},{"key":"key-10.3201\/eid2702.203729-202101221220-R33","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1001\/jama.2020.6637","article-title":"Symptom screening at illness onset of health care personnel with SARS-CoV-2 infection in King County, Washington.","volume":"323","author":"Chow","year":"2020","journal-title":"JAMA"},{"key":"key-10.3201\/eid2702.203729-202101221220-R34","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1177\/0194599820929185","article-title":"Olfactory dysfunction and dinonasal dymptomatology in COVID-19: prevalence, severity, timing, and associated characteristics.","volume":"163","author":"Speth","year":"2020","journal-title":"Otolaryngol Head Neck Surg"},{"key":"key-10.3201\/eid2702.203729-202101221220-R35","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1177\/0194599820939538","article-title":"Olfactory and gustatory outcomes in COVID-19: a prospective evaluation in nonhospitalized subjects.","volume":"163","author":"Paderno","year":"2020","journal-title":"Otolaryngol Head Neck Surg"},{"key":"key-10.3201\/eid2702.203729-202101221220-R36","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s00011-020-01370-w","article-title":"Are the cutaneous manifestations during or due to SARS-CoV-2 infection\/COVID-19 frequent or not? Revision of possible pathophysiologic mechanisms.","volume":"69","author":"Criado","year":"2020","journal-title":"Inflamm Res"},{"key":"key-10.3201\/eid2702.203729-202101221220-R37","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1016\/j.cgh.2019.11.036","article-title":"Evaluation of acute mountain sickness by unsedated transnasal esophagogastroduodenoscopy at high altitude.","volume":"18","author":"Fruehauf","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key-10.3201\/eid2702.203729-202101221220-R38","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/bjd.19163","article-title":"Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases.","volume":"183","author":"Galv\u00e1n Casas","year":"2020","journal-title":"Br J Dermatol"},{"key":"key-10.3201\/eid2702.203729-202101221220-R39","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1056\/NEJMoa2001282","article-title":"A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19.","volume":"382","author":"Cao","year":"2020","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2702.203729-202101221220-R40","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/B978-0-12-385885-6.00009-2","article-title":"Coronavirus pathogenesis.","volume":"81","author":"Weiss","year":"2011","journal-title":"Adv Virus Res"},{"key":"key-10.3201\/eid2702.203729-202101221220-R41","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1128\/CMR.00023-07","article-title":"Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection.","volume":"20","author":"Cheng","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"key-10.3201\/eid2702.203729-202101221220-R42","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1016\/S0140-6736(03)13412-5","article-title":"Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study.","volume":"361","author":"Peiris","year":"2003","journal-title":"Lancet"},{"key":"key-10.3201\/eid2702.203729-202101221220-R43","doi-asserted-by":"publisher","first-page":"993","DOI":"10.15585\/mmwr.mm6930e1","article-title":"CDC COVID-19 Response Team; IVY Network Investigators. Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network\u2014United States, March\u2013June 2020.","volume":"69","author":"Tenforde","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.3201\/eid2702.203729-202101221220-R44","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"key-10.3201\/eid2702.203729-202101221220-R45","doi-asserted-by":"publisher","first-page":"e0238281","DOI":"10.1371\/journal.pone.0238281","article-title":"Characteristics and outcomes of a cohort of COVID-19 patients in the Province of Reggio Emilia, Italy.","volume":"15","author":"Giorgi Rossi","year":"2020","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2702.203729-202101221220-R46","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1097\/YCO.0000000000000267","article-title":"Accuracy and bias in retrospective symptom reporting.","volume":"29","author":"Van den Bergh","year":"2016","journal-title":"Curr Opin Psychiatry"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/27\/2\/20-3729_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T17:50:09Z","timestamp":1732989009000},"score":1,"resource":{"primary":{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/27\/2\/20-3729_article.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"URL":"https:\/\/doi.org\/10.3201\/eid2702.203729","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}