{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:24:09Z","timestamp":1789089849951,"version":"build-2803163510"},"reference-count":27,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.3201\/eid2707.203230","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T12:40:56Z","timestamp":1624279256000},"page":"1902-1908","source":"Crossref","is-referenced-by-count":32,"title":["<i>Plasmodium falciparum kelch<\/i>\n                    <i>13<\/i>\n                    Mutations, 9 Countries in Africa, 2014\u20132018"],"prefix":"10.3201","volume":"27","author":[{"given":"Sarah E.","family":"Schmedes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruviben","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simran","family":"Dhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaly S.","family":"Svigel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Rafael","family":"Dimbu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adicatou-La\u00ef","family":"Adeothy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauthier Mesia","family":"Kahunu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papy Mandoko","family":"Nkoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdoul Habib","family":"Beavogui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Kariuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don P.","family":"Mathanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ousmane","family":"Koita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deus","family":"Ishengoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ally","family":"Mohamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moonga","family":"Hawela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah F.","family":"Moriarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Gutman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz M.","family":"Plucinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatachalam","family":"Udhayakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi W.","family":"Lucchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera","family":"Venkatesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Halsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldin","family":"Talundzic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid2707.203230-202106161255-R1","unstructured":"World Health Organization. World malaria report 2019 [cited 2020 May 15]. https:\/\/www.who.int\/publications\/i\/item\/9789241565721"},{"key":"key-10.3201\/eid2707.203230-202106161255-R2","unstructured":"World Health Organization. Guidelines for the treatment of malaria. 3rd edition. 2015 [cited 2020 May 15]. https:\/\/apps.who.int\/iris\/handle\/10665\/162441"},{"key":"key-10.3201\/eid2707.203230-202106161255-R3","unstructured":"World Health Organization. Artemisinin resistance and artemisinin-based combination therapy efficacy: status report. 2018 [cited 2020 May 15]. https:\/\/apps.who.int\/iris\/handle\/10665\/274362"},{"key":"key-10.3201\/eid2707.203230-202106161255-R4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1126\/science.1215966","article-title":"A major genome region underlying artemisinin resistance in malaria.","volume":"336","author":"Cheeseman","year":"2012","journal-title":"Science"},{"key":"key-10.3201\/eid2707.203230-202106161255-R5","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1073\/pnas.1211205110","article-title":"Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia.","volume":"110","author":"Takala-Harrison","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.3201\/eid2707.203230-202106161255-R6","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nature12876","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.","volume":"505","author":"Ariey","year":"2014","journal-title":"Nature"},{"key":"key-10.3201\/eid2707.203230-202106161255-R7","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of artemisinin resistance in Plasmodium falciparum malaria.","volume":"371","author":"Ashley","year":"2014","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2707.203230-202106161255-R8","unstructured":"World Health Organization. Methods for surveillance of antimalarial drug efficacy. 2009 [cited 2020 May 15]. https:\/\/www.who.int\/malaria\/publications\/atoz\/9789241597531\/en"},{"key":"key-10.3201\/eid2707.203230-202106161255-R9","doi-asserted-by":"publisher","first-page":"S53","DOI":"10.3201\/eid2313.170366","article-title":"Capacity Development through the US President\u2019s Malaria Initiative-Supported Antimalarial Resistance Monitoring in Africa Network.","volume":"23","author":"Halsey","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2707.203230-202106161255-R10","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12936-017-1712-4","article-title":"Efficacy of artemether-lumefantrine, artesunate-amodiaquine, and dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in Angola, 2015.","volume":"16","author":"Plucinski","year":"2017","journal-title":"Malar J"},{"key":"key-10.3201\/eid2707.203230-202106161255-R11","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s12936-018-2233-5","article-title":"Prevalence of molecular markers of artemisinin and lumefantrine resistance among patients with uncomplicated Plasmodium falciparum malaria in three provinces in Angola, 2015.","volume":"17","author":"Ljolje","year":"2018","journal-title":"Malar J"},{"key":"key-10.3201\/eid2707.203230-202106161255-R12","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s12936-018-2290-9","article-title":"Efficacy and safety of artemether-lumefantrine, artesunate-amodiaquine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in three provinces in Angola, 2017.","volume":"17","author":"Davlantes","year":"2018","journal-title":"Malar J"},{"key":"key-10.3201\/eid2707.203230-202106161255-R13","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s12936-020-03358-7","article-title":"Assessment of molecular markers of anti-malarial drug resistance among children participating in a therapeutic efficacy study in western Kenya.","volume":"19","author":"Chebore","year":"2020","journal-title":"Malar J"},{"key":"key-10.3201\/eid2707.203230-202106161255-R14","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12936-019-2730-1","article-title":"Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria and prevalence of Pfk13 and Pfmdr1 polymorphisms after a decade of using artemisinin-based combination therapy in mainland Tanzania.","volume":"18","author":"Ishengoma","year":"2019","journal-title":"Malar J"},{"key":"key-10.3201\/eid2707.203230-202106161255-R15","doi-asserted-by":"publisher","first-page":"e0136099","DOI":"10.1371\/journal.pone.0136099","article-title":"Genetic analysis and species specific amplification of the artemisinin resistance-associated kelch propeller domain in P. falciparum and P. vivax.","volume":"10","author":"Talundzic","year":"2015","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2707.203230-202106161255-R16","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1186\/s13071-015-1253-z","article-title":"Polymorphisms of the artemisinin resistant marker (K13) in Plasmodium falciparum parasite populations of Grande Comore Island 10 years after artemisinin combination therapy.","volume":"8","author":"Huang","year":"2015","journal-title":"Parasit Vectors"},{"key":"key-10.3201\/eid2707.203230-202106161255-R17","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.2147\/IDR.S160164","article-title":"Prevalence of Plasmodium falciparum antimalarial drug resistance genes in Southeastern Gabon from 2011 to 2014.","volume":"11","author":"Voumbo-Matoumona","year":"2018","journal-title":"Infect Drug Resist"},{"key":"key-10.3201\/eid2707.203230-202106161255-R18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12916-018-1207-3","article-title":"Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments-a WWARN individual patient data meta-analysis.","volume":"17","author":"WWARN K13 Genotype-Phenotype Study Group","year":"2019","journal-title":"BMC Med"},{"key":"key-10.3201\/eid2707.203230-202106161255-R19","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1056\/NEJMoa1513137","article-title":"KARMA Consortium. A worldwide map of Plasmodium falciparum K13-propeller polymorphisms.","volume":"374","author":"M\u00e9nard","year":"2016","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2707.203230-202106161255-R20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.9734\/JABB\/2018\/42872","article-title":"Detection of Plasmodium falciparum K13 propeller A569G mutation after artesunate-amodiaquine treatment failure in Niger.","volume":"18","author":"Laminou","year":"2018","journal-title":"J Adv Biol Biotechnol"},{"key":"key-10.3201\/eid2707.203230-202106161255-R21","doi-asserted-by":"publisher","first-page":"e08714","DOI":"10.7554\/eLife.08714","article-title":"Plasmodium falciparum Community Project. Genomic epidemiology of artemisinin resistant malaria.","volume":"5","author":"Malaria","year":"2016","journal-title":"eLife"},{"key":"key-10.3201\/eid2707.203230-202106161255-R22","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12936-019-2701-6","article-title":"K13-propeller gene polymorphisms in Plasmodium falciparum parasite population in malaria affected countries: a systematic review of prevalence and risk factors.","volume":"18","author":"Ocan","year":"2019","journal-title":"Malar J"},{"key":"key-10.3201\/eid2707.203230-202106161255-R23","doi-asserted-by":"publisher","first-page":"e338","DOI":"10.1016\/S1473-3099(19)30261-0","article-title":"Antimalarial drug resistance in Africa: the calm before the storm?","volume":"19","author":"Conrad","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"key-10.3201\/eid2707.203230-202106161255-R24","unstructured":"World Health Organization. Artemisinin and artemisinin-based combination therapy resistance: status report. 2017 [cited 2020 May 15]. https:\/\/apps.who.int\/iris\/handle\/10665\/255213"},{"key":"key-10.3201\/eid2707.203230-202106161255-R25","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1186\/1475-2875-13-431","article-title":"Mutations in Plasmodium falciparum K13 propeller gene from Bangladesh (2009-2013).","volume":"13","author":"Mohon","year":"2014","journal-title":"Malar J"},{"key":"key-10.3201\/eid2707.203230-202106161255-R26","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1038\/s41591-020-1005-2","article-title":"Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda.","volume":"26","author":"Uwimana","year":"2020","journal-title":"Nat Med"},{"key":"key-10.3201\/eid2707.203230-202106161255-R27","doi-asserted-by":"publisher","first-page":"e02474","DOI":"10.1128\/AAC.02474-17","article-title":"Next-generation sequencing and bioinformatics protocol for malaria drug resistance marker surveillance.","volume":"62","author":"Talundzic","year":"2018","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/27\/7\/20-3230_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T12:52:28Z","timestamp":1732971148000},"score":1,"resource":{"primary":{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/27\/7\/20-3230_article.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"URL":"https:\/\/doi.org\/10.3201\/eid2707.203230","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}