{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:22:42Z","timestamp":1775056962224,"version":"3.50.1"},"reference-count":14,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.3201\/eid3205.251926","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T13:46:11Z","timestamp":1775051171000},"source":"Crossref","is-referenced-by-count":0,"title":["Tropism and Replication Competence of Cattle Influenza A(H5N1) Genotype B3.13 Virus in Human Bronchus and Lung Tissue"],"prefix":"10.3201","volume":"32","author":[{"given":"Kenrie P.Y.","family":"Hui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.W.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka-Chun","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Webby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malik","family":"Peiris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Nicholls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.W.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid3205.251926-202604010945-R1","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/s41586-024-08054-z","article-title":"The global H5N1 influenza panzootic in mammals.","volume":"637","author":"Peacock","year":"2025","journal-title":"Nature"},{"key":"key-10.3201\/eid3205.251926-202604010945-R2","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/s44298-025-00138-5","article-title":"Highly pathogenic avian influenza H5N1 in the United States: recent incursions and spillover to cattle.","volume":"3","author":"Mostafa","year":"2025","journal-title":"Npj Viruses"},{"key":"key-10.3201\/eid3205.251926-202604010945-R3","doi-asserted-by":"publisher","first-page":"eadq0900","DOI":"10.1126\/science.adq0900","article-title":"Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle in the United States.","volume":"388","author":"Nguyen","year":"2025","journal-title":"Science"},{"key":"key-10.3201\/eid3205.251926-202604010945-R4","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1056\/NEJMoa2414610","article-title":"Highly pathogenic avian influenza A(H5N1) virus infections in humans.","volume":"392","author":"Garg","year":"2025","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid3205.251926-202604010945-R5","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1056\/NEJMc2405371","article-title":"Highly pathogenic avian influenza A(H5N1) virus infection in a dairy farm worker.","volume":"390","author":"Uyeki","year":"2024","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid3205.251926-202604010945-R6","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3201\/eid3102.241147","article-title":"Comparison of contemporary and historic highly pathogenic avian influenza A(H5N1) virus replication in human lung organoids.","volume":"31","author":"Flagg","year":"2025","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid3205.251926-202604010945-R7","doi-asserted-by":"publisher","first-page":"e662","DOI":"10.1093\/infdis\/jiaf598","article-title":"Avian influenza virus A(H5N1) genotype D1.1 is better adapted to human nasal and airway organoids than genotype B3.13.","volume":"233","author":"Zhang","year":"2026","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid3205.251926-202604010945-R8","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1038\/s41586-024-08254-7","article-title":"A human isolate of bovine H5N1 is transmissible and lethal in animal models.","volume":"636","author":"Gu","year":"2024","journal-title":"Nature"},{"key":"key-10.3201\/eid3205.251926-202604010945-R9","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.cell.2025.01.019","article-title":"Receptor binding, structure, and tissue tropism of cattle-infecting H5N1 avian influenza virus hemagglutinin.","volume":"188","author":"Song","year":"2025","journal-title":"Cell"},{"key":"key-10.3201\/eid3205.251926-202604010945-R10","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41586-024-07766-6","article-title":"Pathogenicity and transmissibility of bovine H5N1 influenza virus.","volume":"633","author":"Eisfeld","year":"2024","journal-title":"Nature"},{"key":"key-10.3201\/eid3205.251926-202604010945-R11","doi-asserted-by":"publisher","first-page":"6771","DOI":"10.1038\/s41467-025-61757-3","article-title":"Genotype B3.13 influenza A(H5N1) viruses isolated from dairy cattle demonstrate high virulence in laboratory models, but retain avian virus-like properties.","volume":"16","author":"Fabrizio","year":"2025","journal-title":"Nat Commun"},{"key":"key-10.3201\/eid3205.251926-202604010945-R12","doi-asserted-by":"publisher","first-page":"E18","DOI":"10.1038\/s41586-025-08821-6","article-title":"Bovine H5N1 binds poorly to human-type sialic acid receptors.","volume":"640","author":"Santos","year":"2025","journal-title":"Nature"},{"key":"key-10.3201\/eid3205.251926-202604010945-R13","doi-asserted-by":"publisher","first-page":"E21","DOI":"10.1038\/s41586-025-08822-5","article-title":"Receptor-binding specificity of a bovine influenza A virus.","volume":"640","author":"Chopra","year":"2025","journal-title":"Nature"},{"key":"key-10.3201\/eid3205.251926-202604010945-R14","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1016\/S0140-6736(02)11772-7","article-title":"Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?","volume":"360","author":"Cheung","year":"2002","journal-title":"Lancet"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T13:46:11Z","timestamp":1775051171000},"score":1,"resource":{"primary":{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/32\/5\/25-1926_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"URL":"https:\/\/doi.org\/10.3201\/eid3205.251926","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}