{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:21:46Z","timestamp":1779366106729,"version":"3.53.0"},"reference-count":36,"publisher":"Siapec Servizi Srl","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathologica"],"DOI":"10.32074\/1591-951x-1091","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T07:41:34Z","timestamp":1749195694000},"page":"111-120","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of papillary thryoid carcinoma and its variants: multifocality in thyroid lobectomy and completion thyroidectomy - a single tertiary center retrospective study"],"prefix":"10.32074","volume":"117","author":[{"given":"Carmine","family":"Bruno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Tralongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Vegni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Feraco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Padial-Urtueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Carlino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Pontecorvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Fadda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Raffaelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi Maria","family":"Larocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liron","family":"Pantanowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther Diana","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"21774","published-online":{"date-parts":[[2025,5]]},"reference":[{"key":"10.32074\/1591-951X-1091_ref1","doi-asserted-by":"crossref","unstructured":"Bilimoria KY, Bentrem DJ, Ko CY, et al. Extent of surgery affects survival for papillary thyroid cancer. Ann Surg. 2007;246(3):375-84.","DOI":"10.1097\/SLA.0b013e31814697d9"},{"key":"10.32074\/1591-951X-1091_ref2","doi-asserted-by":"crossref","unstructured":"La Vecchia C, Malvezzi M, Bosetti C, et al. Thyroid cancer mortality and incidence: a global overview. Int J Cancer. 2015;136(9):2187-95.","DOI":"10.1002\/ijc.29251"},{"key":"10.32074\/1591-951X-1091_ref3","doi-asserted-by":"crossref","unstructured":"Lamartina L, Grani G, Durante C, et al. Follow-up of differentiated thyroid cancer: what should (and what should not) be done. Nat Rev Endocrinol. 2018;14(9):538-51.","DOI":"10.1038\/s41574-018-0068-3"},{"key":"10.32074\/1591-951X-1091_ref4","doi-asserted-by":"crossref","unstructured":"Haugen BR, Alexander EK, Bible KC, et al. 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1-133.","DOI":"10.1089\/thy.2015.0020"},{"key":"10.32074\/1591-951X-1091_ref5","doi-asserted-by":"crossref","unstructured":"Barney BM, Hitchcock YJ, Sharma P, et al. Overall and cause-specific survival for patients undergoing lobectomy, near-total, or total thyroidectomy for differentiated thyroid cancer. Head Neck. 2011;33(5):645-9.","DOI":"10.1002\/hed.21504"},{"key":"10.32074\/1591-951X-1091_ref6","doi-asserted-by":"crossref","unstructured":"Doran HE, England J, Palazzo F. Questionable safety of thyroid surgery with same day discharge. Ann R Coll Surg Engl. 2012;94(8):543-547.","DOI":"10.1308\/003588412X13373405384576"},{"key":"10.32074\/1591-951X-1091_ref7","doi-asserted-by":"crossref","unstructured":"Van Gerwer M, Alsen M, Lee E, et al. Recurrence-free survival after total thyroidectomy and lobectomy in patients with papillary thyroid microcarcinoma. J Endocrinol Invest. 2021;44(4):725-734.","DOI":"10.1007\/s40618-020-01342-1"},{"key":"10.32074\/1591-951X-1091_ref8","doi-asserted-by":"crossref","unstructured":"Moore C Edwina, Zolin S, Krishamurthy V, et al. Need for Completion Thyroidectomy in Patients Undergoing Lobectomy for Indeterminate and High-Risk Nodules: Impact of Intra-Operative Findings and Final Pathology. World J Surg. 2020;44:408-16.","DOI":"10.1007\/s00268-019-05189-3"},{"key":"10.32074\/1591-951X-1091_ref9","doi-asserted-by":"crossref","unstructured":"Park JH, Yoon JH. Lobectomy in patients with differentiated thyroid cancer: indications and follow-up. Endocr Relat Cancer. 2019;26(7):R381-R39.","DOI":"10.1530\/ERC-19-0085"},{"key":"10.32074\/1591-951X-1091_ref10","doi-asserted-by":"crossref","unstructured":"Matsuzu K, Sugino K, Masudo K, et al. Thyroid lobectomy for papillary thyroid cancer: long-term follow-up study of 1,088 cases. World J Surg. 2014;38(1):68-79.","DOI":"10.1007\/s00268-013-2224-1"},{"key":"10.32074\/1591-951X-1091_ref11","doi-asserted-by":"crossref","unstructured":"Liu J. Zhang Z, Huang H, Xu S, et al. Total thyroidectomy versus lobectomy for intermediate-risk papillary thyroid carcinoma: A single-institution matched-pair analysis. Oral Oncol. 2019;90:17-22.","DOI":"10.1016\/j.oraloncology.2019.01.010"},{"key":"10.32074\/1591-951X-1091_ref12","doi-asserted-by":"crossref","unstructured":"Vargas-Pinto S, Arenas MAR. Lobectomy Compared to Total Thyroidectomy for Low-Risk Papillary Thyroid Cancer: a Systematic Review. J Surg Res. 2019;242;244-51.","DOI":"10.1016\/j.jss.2019.04.036"},{"key":"10.32074\/1591-951X-1091_ref13","doi-asserted-by":"crossref","unstructured":"DiMarco AN, Wong MS, Jayasekara J, Cole-Clark D, et al. Risk of needing completion thyroidectomy for low-risk papillary thyroid cancers treated by lobectomy. BJS Open. 2019;6:299-304.","DOI":"10.1002\/bjs5.50137"},{"key":"10.32074\/1591-951X-1091_ref14","doi-asserted-by":"crossref","unstructured":"Craig SJ, Bysice AM, Nakoneshny SC, Pasieka JL, et al. The Identification of Intraoperative Risk Factors Can Reduce, but Not Exclude, the Need for Completion Thyroidectomy in Low-Risk Papillary Thyroid Cancer Patients. Thyroid. 2020;30:222-28.","DOI":"10.1089\/thy.2019.0274"},{"key":"10.32074\/1591-951X-1091_ref15","doi-asserted-by":"crossref","unstructured":"Kluijfhout WP, Pasternak JD, Lim J, et al. Frequency of High-Risk Characteristics Requiring Total Thyroidectomy for 1-4 cm Well-Differentiated Thyroid Cancer. Thyroid. 2016;26;820-24.","DOI":"10.1089\/thy.2015.0495"},{"key":"10.32074\/1591-951X-1091_ref16","doi-asserted-by":"crossref","unstructured":"Macedo FIB, Mittal VK. Total thyroidectomy versus lobectomy as initial operation for small unilateral papillary thyroid carcinoma: A meta-analysis. Surg Oncol. 2015;24:117-24.","DOI":"10.1016\/j.suronc.2015.04.005"},{"key":"10.32074\/1591-951X-1091_ref17","doi-asserted-by":"crossref","unstructured":"Luster M, Aktolun C, Amendoeira I, et al. European Perspective on 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: Proceedings of an Interactive International Symposium. Thyroid. 2019;29:7-26.","DOI":"10.1089\/thy.2017.0129"},{"key":"10.32074\/1591-951X-1091_ref18","doi-asserted-by":"crossref","unstructured":"Adam MA, Pura J, Gu L, et al. Extent of surgery for papillary thyroid cancer is not associated with survival: an analysis of 61,775 patients. Ann Surg. 2014;260(4):601-7.","DOI":"10.1097\/SLA.0000000000000925"},{"key":"10.32074\/1591-951X-1091_ref19","doi-asserted-by":"crossref","unstructured":"Kim SK, Park I, Woo JW, et al. Predicting Factors for Bilaterality in Papillary Thyroid Carcinoma with Tumor Size < 4 cm. Thyroid 2017;27(2):207-214.","DOI":"10.1089\/thy.2016.0190"},{"key":"10.32074\/1591-951X-1091_ref20","doi-asserted-by":"crossref","unstructured":"Ali S and Cibas ES. The Bethesda system for reporting thyroid cytopathology. 2nd Edition. Springer, Berlin 2018.","DOI":"10.1007\/978-3-319-60570-8"},{"key":"10.32074\/1591-951X-1091_ref21","unstructured":"Perros P, Boelaert K, Colley S, et al. Guidelines for the management of thyroid cancer. Report of the Thyroid Cancer Guidelines Update Group. British Thyroid Association, Royal College of Physicians. London. 2007, 3rd edition."},{"key":"10.32074\/1591-951X-1091_ref22","doi-asserted-by":"crossref","unstructured":"Nardi F, Basolo F, Crescenzi A, et al. Italian consensus for the classification and reporting of thyroid cytology. J Endocrinol Invest. 2014;37:593-9.","DOI":"10.1007\/s40618-014-0062-0"},{"key":"10.32074\/1591-951X-1091_ref23","doi-asserted-by":"crossref","unstructured":"Rossi ED, Martini M, Capodimonti S, et al. Analysis of immunocytochemical and molecular BRAF expression in thyroid carcinomas: a cyto-histological institutional experience. Cancer Cytopathol. 2014;122:52-56.","DOI":"10.1002\/cncy.21416"},{"key":"10.32074\/1591-951X-1091_ref24","doi-asserted-by":"crossref","unstructured":"Rossi ED, Martini M, Capodimonti S, et al. Morphology combined with ancillary techniques: An algorithm approach for thyroid nodules. Cytopathol 2018;29:418-27.","DOI":"10.1111\/cyt.12555"},{"key":"10.32074\/1591-951X-1091_ref25","doi-asserted-by":"crossref","unstructured":"Rossi ED, Martini M, Capodimonti S, et al. BRAF (v600e) mutation analysis on LBC-processed aspiration biopsies predicts bilaterality and nodal involvement in papillary thyroid microcarcinoma. Cancer Cytopathol. 2013;121:291-7.","DOI":"10.1002\/cncy.21258"},{"key":"10.32074\/1591-951X-1091_ref26","unstructured":"Lloyd RV, Osamura RY, Kloppel G, et al. (Eds). WHO Classification of Tumours of Endocrine Organs (4th edition). IARC: Lyon 2017."},{"key":"10.32074\/1591-951X-1091_ref27","doi-asserted-by":"crossref","unstructured":"Nikiforov YE, Seethala RR, Tallini G, et al. Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma: a paradigm shift to reduce overtreatment of indolent tumors. JAMA Oncol 2016;2(8):1023-9.","DOI":"10.1001\/jamaoncol.2016.0386"},{"key":"10.32074\/1591-951X-1091_ref28","unstructured":"American Joint Commission on Cancer (AJCC) Cancer Staging Atlas, 2017 8th Edition."},{"key":"10.32074\/1591-951X-1091_ref29","doi-asserted-by":"crossref","unstructured":"Al Dawish MA, Rober AA, Thabet MA, et al. Thyroid nodule management: thyroid-stimulating hormone, ultrasound and cytological classification system for predicting malignancy. Cancer Inform. 2018;17:1-9.","DOI":"10.1177\/1176935118765132"},{"key":"10.32074\/1591-951X-1091_ref30","doi-asserted-by":"crossref","unstructured":"Grani G, Sponziello M, Pecce v, et al. Contemporary thyroid evaluation and management. J Clin Endocrinol Metab. 2020;105: 2869-83.","DOI":"10.1210\/clinem\/dgaa322"},{"key":"10.32074\/1591-951X-1091_ref31","doi-asserted-by":"crossref","unstructured":"Frates MC, Benson CB, Charboneau JW, et al. Management of thyroid nodules detected at US: Society of radiologists in ultrasound consensus conference statement. Radiology. 2005 ;237: 794-800.","DOI":"10.1148\/radiol.2373050220"},{"key":"10.32074\/1591-951X-1091_ref32","doi-asserted-by":"crossref","unstructured":"Gharib H, Papini E, Garber JR, et al. American association of clinical endocrinologist, american college of endocrinology, and associazione medici endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: 2016 update. Endocrin Pract. 2016;22:622-39.","DOI":"10.4158\/EP161208.GL"},{"key":"10.32074\/1591-951X-1091_ref33","unstructured":"National comprehensive Cancer Network. NCCN Clinical practice guidelines in oncology and (NCCN guidelines) and thyroid carcinoma version 2.2014. Fort Washington, PA: National Comprehensive Cancer Network 2014."},{"key":"10.32074\/1591-951X-1091_ref34","doi-asserted-by":"crossref","unstructured":"van Gerwen M, Cooke PV, Alpert N, et al. Patient-reported outcomes following total thyroidectomy and lobectomy in thyroid cancer survivors: an analysis of the Profiles Registry data. Support Care Cancer. 2022;30(1):687-693.","DOI":"10.1007\/s00520-021-06355-x"},{"key":"10.32074\/1591-951X-1091_ref35","doi-asserted-by":"crossref","unstructured":"Grant EG, Tessler FN, Hoang JK, et al. Thyroid ultrasound reporting lexicon: White paper of the ACR thyroid imaging reporting and data system (TIRADS) committee. J Am Coll Radiol. 2015;12(Part A):1272-1279.","DOI":"10.1016\/j.jacr.2015.07.011"},{"key":"10.32074\/1591-951X-1091_ref36","doi-asserted-by":"crossref","unstructured":"Tessler FN, Middleton WD, Grant EG, et al. ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee. J Am Coll Radiol. JACR. 2017;14(5):587-595.","DOI":"10.1016\/j.jacr.2017.01.046"}],"container-title":["Pathologica"],"original-title":[],"link":[{"URL":"https:\/\/www.pathologica.it\/article\/view\/1346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T07:43:10Z","timestamp":1749195790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pathologica.it\/article\/view\/1346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":36,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4]]}},"URL":"https:\/\/doi.org\/10.32074\/1591-951x-1091","relation":{},"ISSN":["1591-951X"],"issn-type":[{"value":"1591-951X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"article-number":"5"}}