{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T15:55:25Z","timestamp":1777305325600,"version":"3.51.4"},"reference-count":29,"publisher":"Siapec Servizi Srl","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathologica"],"DOI":"10.32074\/1591-951x-374","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T09:48:03Z","timestamp":1638006483000},"page":"354-359","source":"Crossref","is-referenced-by-count":7,"title":["\u201cBorderline\u201d epithelial lesions of the breast: what have we learned in the past three decades?"],"prefix":"10.32074","volume":"113","author":[{"given":"Anna","family":"Sapino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Marchi\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janina","family":"Kulka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"21774","published-online":{"date-parts":[[2021,10]]},"reference":[{"key":"10.32074\/1591-951X-374_ref1","doi-asserted-by":"crossref","unstructured":"Rosai J. Borderline epithelial lesions of the breast. Am J Surg Pathol 1991;15:209-21. https:\/\/doi.org\/10.1097\/00000478-199103000-00001","DOI":"10.1097\/00000478-199103000-00001"},{"key":"10.32074\/1591-951X-374_ref2","doi-asserted-by":"crossref","unstructured":"Page DL, Dupont WD, Rogers LW, et al. Atypical hyperplastic lesions of the female breast: a long-term fol\u00adlow-up study. Cancer 1985;55:2698-708. https:\/\/doi.org\/10.1002\/1097-0142(19850601)55:11<2698::aid-cncr2820551127>3.0.co;2-a","DOI":"10.1002\/1097-0142(19850601)55:11<2698::AID-CNCR2820551127>3.0.CO;2-A"},{"key":"10.32074\/1591-951X-374_ref3","doi-asserted-by":"crossref","unstructured":"Dupont WD, Page DL. Risk factors for breast cancer in women with proliferative breast disease. N Eng J Med 1985;312:146-51. https:\/\/doi.org\/10.1056\/NEJM198501173120303","DOI":"10.1056\/NEJM198501173120303"},{"key":"10.32074\/1591-951X-374_ref4","unstructured":"Page DL, Anderson TJ. Diagnostic histopathology of the breast. Edinburgh: Churchill Livingstone 1987, pp. 137, 139, 145."},{"key":"10.32074\/1591-951X-374_ref5","doi-asserted-by":"crossref","unstructured":"Tavassoli FA, Norris HJ. A comparison of the results of long-term follow-up for atypical intraductal hyperplasia and intraductal hyperplasia of the breast. Cancer 1990;65:518-29. https:\/\/doi.org\/10.1002\/1097-0142(19900201)65:3<518::aid-cncr2820650324>3.0.co;2-o","DOI":"10.1002\/1097-0142(19900201)65:3<518::AID-CNCR2820650324>3.0.CO;2-O"},{"key":"10.32074\/1591-951X-374_ref6","unstructured":"Breast Tumours, WHO Classification of Tumours, 5th Edition, ed. WHO Classification Editorial Board. Lyon: France, IARC 2019."},{"key":"10.32074\/1591-951X-374_ref7","doi-asserted-by":"crossref","unstructured":"Kimberly HA, Rendi HM, Peacock S, et al. Histologic Features associated with diagnostic agreement in atypical ductal hyperplasia of the breast: illustrative cases from the B-Path study. Histopathology 2016;69:1028-1046. https:\/\/doi.org\/10.1111\/his.13035","DOI":"10.1111\/his.13035"},{"key":"10.32074\/1591-951X-374_ref8","unstructured":"Hutter RVP. Consensus meeting: is \u201cfibrocystic disease\u201d of the breast precancerous? Arch Pathol Lab Med 1986;110:171-173. PMID: 3606334."},{"key":"10.32074\/1591-951X-374_ref9","doi-asserted-by":"crossref","unstructured":"Page DL, Dupont WD, Rogers LW. Ductal involvement by cells of atypical lobular hyperplasia in the breast: a long\u00adterm follow-up study of cancer risk. Hum Pathol 1988;19:201-207. https:\/\/doi.org\/10.1016\/s0046-8177(88)80350-2","DOI":"10.1016\/S0046-8177(88)80350-2"},{"key":"10.32074\/1591-951X-374_ref10","doi-asserted-by":"crossref","unstructured":"Page DL, Rogers LW. Combined histologic and cytologic criteria for the diagnosis of mammary atypical ductal hyperplasia. Hum Pathol 1992;23:1095-1097. https:\/\/doi.org\/10.1016\/0046-8177(92)90026-y","DOI":"10.1016\/0046-8177(92)90026-Y"},{"key":"10.32074\/1591-951X-374_ref11","doi-asserted-by":"crossref","unstructured":"Elston CW, Sloane JP, Amendoeira I, et al. Causes of inconsistency in diagnosing and classifying intraductal proliferations of the breast. European Commission Working Group on Breast Screening Pathology. Eur J Cancer 2000;36:1769-1772. https:\/\/doi.org\/10.1016\/s0959-8049(00)00181-7","DOI":"10.1016\/S0959-8049(00)00181-7"},{"key":"10.32074\/1591-951X-374_ref12","doi-asserted-by":"crossref","unstructured":"Schnitt SJ, Vincent-Salomon A. Columnar cell lesions of the breast. Adv Anat Pathol 2003;3:113-124. https:\/\/doi.org\/10.1097\/00125480-200305000-00001","DOI":"10.1097\/00125480-200305000-00001"},{"key":"10.32074\/1591-951X-374_ref13","doi-asserted-by":"crossref","unstructured":"Schnitt SJ. The diagnosis and management of pre-invasive breast disease flat epithelial atypia - classification, pathologic features. Breast Cancer Res 2003;5:263-268. https:\/\/doi.org\/10.1186\/bcr625","DOI":"10.1186\/bcr625"},{"key":"10.32074\/1591-951X-374_ref14","doi-asserted-by":"crossref","unstructured":"Otterbach F, B\u00e0nkfalvi A, Bergner S, et al. Cytokeratin 5\/6 immunohistochemistry assists the differential diagnosis of atypical proliferations of the breast. Histopathology 2000;37:232-240. https:\/\/doi.org\/10.1046\/j.1365-2559.2000.00882.x","DOI":"10.1046\/j.1365-2559.2000.00882.x"},{"key":"10.32074\/1591-951X-374_ref15","doi-asserted-by":"crossref","unstructured":"Bhattacharjee DK, Harris M, Faragher EB. Nuclear morphometry of epitheliosis and intraduct carcinoma of the breast. Histopathology 1985;9:511-516. https:\/\/doi.org\/10.1111\/j.1365-2559.1985.tb02832.x","DOI":"10.1111\/j.1365-2559.1985.tb02832.x"},{"key":"10.32074\/1591-951X-374_ref16","unstructured":"Guski H, Hufnagl P, Kaufmann O, et al. AgNOR analysis of atypical ductal hyperplasia and intraductal carcinoma of the breast. Anal Quant Cytol Histol 2000;22:206-216. PMID: 10872036"},{"key":"10.32074\/1591-951X-374_ref17","doi-asserted-by":"crossref","unstructured":"Santisteban M, Reynolds C, Barr Fritcher EG, et al. Ki67: a time-varying biomarker of risk of breast cancer in atypical hyperplasia. Breast Cancer Res Treat 2010;121:431-437. https:\/\/doi.org\/10.1007\/s10549-009-0534-7","DOI":"10.1007\/s10549-009-0534-7"},{"key":"10.32074\/1591-951X-374_ref18","unstructured":"Thor A, Ohuchi N, Hand PH, et al. Ras gene alterations and enhanced levels of ras p21 expression in a spectrum of benign and malignant human mammary tissues. Lab lnvest 1986;55:603-615. PMID: 2431221."},{"key":"10.32074\/1591-951X-374_ref19","doi-asserted-by":"crossref","unstructured":"Danforth DN. Molecular profile of atypical hyperplasia of the breast. Breast Cancer Res Treat 2018;167:9-29. https:\/\/doi.org\/10.1007\/s10549-017-4488-x","DOI":"10.1007\/s10549-017-4488-x"},{"key":"10.32074\/1591-951X-374_ref20","doi-asserted-by":"crossref","unstructured":"Kader T, Hill P, Rakha EA, et al. Atypical ductal hyperplasia: update on diagnosis, management, and molecular landscape. Breast Cancer Research 2018;20:39. https:\/\/doi.org\/10.1186\/s13058-018-0967-1","DOI":"10.1186\/s13058-018-0967-1"},{"key":"10.32074\/1591-951X-374_ref21","unstructured":"Roger P, Sahla ME, Makela S, et al. Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors. Cancer Res 2001;61:2537-2541. PMID: 11289127."},{"key":"10.32074\/1591-951X-374_ref22","doi-asserted-by":"crossref","unstructured":"Hoogerbrugge N, Bult P, de Widt-Levert LM, et al. High prevalence of premalignant lesions in prophylactically removed breasts from women at hereditary risk for breast cancer. J Clin Oncol 2003;21:41-45. https:\/\/doi.org\/10.1200\/JCO.2003.02.137","DOI":"10.1200\/JCO.2003.02.137"},{"key":"10.32074\/1591-951X-374_ref23","doi-asserted-by":"crossref","unstructured":"Harvey DG, Fechner RE. Atypical lobular and papillary lesions of the breast: A follow-up study of 30 cases. South Med J 1978;71:361-4. https:\/\/doi.org\/10.1097\/00007611-197804000-00004","DOI":"10.1097\/00007611-197804000-00004"},{"key":"10.32074\/1591-951X-374_ref24","doi-asserted-by":"crossref","unstructured":"Buckley CH, Butler EB, Fox H. Cervical intraepithelial neoplasia. J Clin Pathol 1982;35:1-13. https:\/\/doi.org\/10.1136\/jcp.35.1.1","DOI":"10.1136\/jcp.35.1.1"},{"key":"10.32074\/1591-951X-374_ref25","doi-asserted-by":"crossref","unstructured":"Tavassoli FA. Mammary intraepithelial neoplasia: a translational classification system for the intraductal epithelial proliferations. Breast J 1997;3:48-58. doi.org\/10.1111\/j.1524-4741.1997.tb00139.x","DOI":"10.1111\/j.1524-4741.1997.tb00139.x"},{"key":"10.32074\/1591-951X-374_ref26","unstructured":"Tavassoli FA. Ductal carcinoma in situ: introduction of the concept of ductal intraepithelial neoplasia. Mod Pathol 1998;11:140-54. PMID: 9504685."},{"key":"10.32074\/1591-951X-374_ref27","unstructured":"Tavassoli FA, Devilee P. Pathology and Genetics: Tumours of the Breast and Female Genital Organs. WHO Classification of Tumours series - volume IV. Lyon, France: IARC Press 2003. ISBN 92 832 2412 4"},{"key":"10.32074\/1591-951X-374_ref28","unstructured":"Lakhani SR, Ellis IO, Schnitt SJ et al. eds. World Health Organization classi\ufb01cation of tumours of the breast. 4th ed. Lyon: IARC Press, 2012."},{"key":"10.32074\/1591-951X-374_ref29","unstructured":"WHO Classification of Tumors Editorial Board, ed. WHO classification of tumors, 5th edition - Breast tumors. Lyon: International Agency for Research on Cancer 201."}],"container-title":["Pathologica"],"original-title":[],"link":[{"URL":"https:\/\/www.pathologica.it\/article\/view\/374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:26:25Z","timestamp":1730813185000},"score":1,"resource":{"primary":{"URL":"https:\/\/old.pathologica.it\/article\/view\/374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":29,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,10]]}},"URL":"https:\/\/doi.org\/10.32074\/1591-951x-374","relation":{},"ISSN":["1591-951X"],"issn-type":[{"value":"1591-951X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"article-number":"8"}}