{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T05:24:00Z","timestamp":1740201840939,"version":"3.37.3"},"reference-count":0,"publisher":"IOS Press","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Background: The characterization of spontaneous reported cases is fundamental for pharmacovigilance. This task is time consuming and its reproducibility is low. Objective: To develop a system founded on an ontology that automatically instantiates spontaneous reported cases as &amp;ldquo;known&amp;rdquo; adverse drug effects (ADE) only if the reported ADEs are described in drug compendia. Methods: A simple ontology of drugs and their related adverse effects represented in description logics was developed from a drug database. Manual evaluation was carried out on 378 spontaneous reported cases instantiated as &amp;ldquo;known ADE of a chemical class&amp;rdquo;. The initial manual characterization was reviewed by a pharmacovigilance expert to validate the generated automatic characterization. Results: The ontology is composed by 57,04 concepts and 5 relations. It was successfully validated thanks to Pellet reasoner and it contains neither inconsistencies nor cycles. In this validation, 86% of the instantiated spontaneous reported cases effectively concerned notorious ADEs, whereas only 75% were initially identified manually as related to notorious ADEs. Conclusion: This system can assist characterization by applying a reasoning process similar to that used by experts in the search for ADEs.<\/jats:p>","DOI":"10.3233\/978-1-60750-588-4-1005","type":"book-chapter","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:02:47Z","timestamp":1740128567000},"source":"Crossref","is-referenced-by-count":0,"title":["Modeling, building and evaluating an ontology for the automatic characterization of adverse drug effects during pharmacovigilance"],"prefix":"10.3233","author":[{"family":"Duclos Catherine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Soualmia Lina F.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Krivine Sonia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jamet Anne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Lillo-Lou&euml;t Agnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","MEDINFO 2010"],"original-title":[],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:41:17Z","timestamp":1740130877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospressISSNISBN&issn=0926-9630&volume=160&spage=1005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/978-1-60750-588-4-1005","relation":{},"ISSN":["0926-9630"],"issn-type":[{"value":"0926-9630","type":"print"}],"subject":[],"published":{"date-parts":[[2010]]}}}