{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T05:36:28Z","timestamp":1740202588585,"version":"3.37.3"},"reference-count":0,"publisher":"IOS Press","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>Domain parsing, or the detection of signals of protein structural domains from sequence data, is a complex and difficult problem. If carried out reliably it would be a powerful interpretive and predictive tool for genomic and proteomic studies. We report on a novel approach to domain parsing using consensus techniques based on Hidden Markov Models (HMMs) and BLAST searches built from a training set of 1471 continuous structural domains from the Dali Domain Dictionary (DDD). Validation on an independent test sample of family-matched structural domain sequences from the Scop database yields a consensus prediction performance rate of 75.5%, well above the 58% obtained by simple agreement of methods.<\/jats:p>","DOI":"10.3233\/978-1-60750-928-8-965","type":"book-chapter","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:29:25Z","timestamp":1740158965000},"source":"Crossref","is-referenced-by-count":0,"title":["Protein Structural Domain Parsing by Consensus Reasoning over Multiple Knowledge Sources and Methods"],"prefix":"10.3233","author":[{"family":"Kulikowski Casimir A.","sequence":"additional","affiliation":[]},{"family":"Muchnik Ilya","sequence":"additional","affiliation":[]},{"family":"Yun HwaSeob J.","sequence":"additional","affiliation":[]},{"family":"Dayanik Aynur A.","sequence":"additional","affiliation":[]},{"family":"Zhang Deyou","sequence":"additional","affiliation":[]},{"family":"Song Yueyue","sequence":"additional","affiliation":[]},{"family":"Montelione Gaetano T.","sequence":"additional","affiliation":[]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","MEDINFO 2001"],"original-title":[],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:03:19Z","timestamp":1740160999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospressISSNISBN&issn=0926-9630&volume=84&spage=965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/978-1-60750-928-8-965","relation":{},"ISSN":["0926-9630"],"issn-type":[{"value":"0926-9630","type":"print"}],"subject":[],"published":{"date-parts":[[2001]]}}}