{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T05:37:17Z","timestamp":1740202637762,"version":"3.37.3"},"reference-count":0,"publisher":"IOS Press","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>Like any chronic disease, hypertension is complex to manage. Despite the availability of evidence-based clinical practice guidelines in most countries, a lot of hypertensive patients remain inadequately managed. One difficulty lies in the synchronization of a patient&amp;apos;s own therapeutic history with the guideline strategy. We propose a formal model to represent guideline-based therapeutic strategies as bi-dimensional matrices. We built the knowledge base as a two-level decision tree to be read during an hypertextual navigation. The first level is used to identify a patient-specific clinical situation on the basis of key elements of clinical examination (complication of hypertension, associated diseases). The second level aims at dynamically refining the theoretical strategy, a priori established in the guideline for the corresponding clinical situation, by the specific therapeutic history of the patient. Finally, depending on the patient&amp;rsquo;s response to the ongoing treatment, the system provides a recommendation consistent with the guideline strategy, whatever the patient&amp;rsquo;s past treatments. A first evaluation of the system on simulated cases has been well accepted by general practitioners.<\/jats:p>","DOI":"10.3233\/978-1-60750-939-4-537","type":"book-chapter","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:13:02Z","timestamp":1740157982000},"source":"Crossref","is-referenced-by-count":0,"title":["Modeling patient-specific therapeutic strategy in the guideline-based management of a chronic disease"],"prefix":"10.3233","author":[{"family":"S&eacute;roussi Brigitte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Bouaud Jacques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Chatellier Gilles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","The New Navigators: from Professionals to Patients"],"original-title":[],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:01:41Z","timestamp":1740160901000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospressISSNISBN&issn=0926-9630&volume=95&spage=537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/978-1-60750-939-4-537","relation":{},"ISSN":["0926-9630"],"issn-type":[{"value":"0926-9630","type":"print"}],"subject":[],"published":{"date-parts":[[2003]]}}}