{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T05:36:33Z","timestamp":1740202593021,"version":"3.37.3"},"reference-count":0,"publisher":"IOS Press","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>Objectives: To assess the acceptability to clinicians of a webbased decision support system designed to assist with dosage adjustments during maintenance therapy for childhood Acute Lymphoblastic Leukaemia (ALL), and to evaluate the potential impact of the system on decision-making and dosage calculations. Design: Balanced-block crossover experiment with simulated cases; questionnaire study and semi-structured interviews. Participants: 36 clinicians with differing experience in the management of ALL. Interventions: Subjects were asked to decide on appropriate levels of chemotherapy dosing for 8 simulated cases, 4 using the LISA decision support system, 4 using conventional paper-based records and guidance. Main outcome measures: Number of protocol-consistent dosage decisions made; time taken to manage each case; accuracy of dosage calculations; subjects&amp;apos; opinions as to whether or not they would use the system in practice. Additional outcome measures: Functions subjects would like to see in an idealised system; subjects&amp;rsquo;satisfaction with the implementation of the functions provided by LISA; qualitative data on issues subjects felt would impact upon the successful deployment of the system.<\/jats:p>","DOI":"10.3233\/978-1-60750-949-3-197","type":"book-chapter","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:29:25Z","timestamp":1740158965000},"source":"Crossref","is-referenced-by-count":0,"title":["A quantitative and qualitative evaluation of LISA, a decision support system for chemotherapy dosing in childhood Acute Lymphoblastic Leukaemia."],"prefix":"10.3233","author":[{"family":"Bury Jonathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Hurt Chris.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Roy Anindita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Bradburn Mike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Cross Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Fox John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Saha Vaskar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","MEDINFO 2004"],"original-title":[],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:15:49Z","timestamp":1740161749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospressISSNISBN&issn=0926-9630&volume=107&spage=197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/978-1-60750-949-3-197","relation":{},"ISSN":["0926-9630"],"issn-type":[{"value":"0926-9630","type":"print"}],"subject":[],"published":{"date-parts":[[2004]]}}}