{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T05:37:15Z","timestamp":1740202635347,"version":"3.37.3"},"reference-count":0,"publisher":"IOS Press","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Metformin is a commonly prescribed diabetes medication whose mechanism of action is poorly understood. In this study we utilized EHR-linked biobank data to elucidate the impact of genomic variation on glycemic response to metformin. Our study found significant gene- and SNP-level associations within the beta-2 subunit of the heterotrimeric adenosine monophosphate-activated protein kinase complex. Using EHR phenotypes where were able to add additional clarity to ongoing metformin pharmacogenomic dialogue.<\/jats:p>","DOI":"10.3233\/978-1-61499-512-8-914","type":"book-chapter","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:09:19Z","timestamp":1740161359000},"source":"Crossref","is-referenced-by-count":0,"title":["Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics"],"prefix":"10.3233","author":[{"family":"Breitenstein Matthew K.","sequence":"additional","affiliation":[]},{"family":"Simon Gyorgy","sequence":"additional","affiliation":[]},{"family":"Ryu Euijung","sequence":"additional","affiliation":[]},{"family":"Armasu Sebastian M.","sequence":"additional","affiliation":[]},{"family":"Weinshilboum Richard M.","sequence":"additional","affiliation":[]},{"family":"Wang Liewei","sequence":"additional","affiliation":[]},{"family":"Pathak Jyotishman","sequence":"additional","affiliation":[]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Digital Healthcare Empowering Europeans"],"original-title":[],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:50:05Z","timestamp":1740163805000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospressISBN&isbn=978-1-61499-511-1&spage=914&doi=10.3233\/978-1-61499-512-8-914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/978-1-61499-512-8-914","relation":{},"ISSN":["0926-9630"],"issn-type":[{"value":"0926-9630","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}