{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T05:37:06Z","timestamp":1740202626442,"version":"3.37.3"},"reference-count":0,"publisher":"IOS Press","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>This paper presents the idea of an ROC curve, which quantifies the discriminatory potential of a continuous biomarker for treatment selection when the outcome is continuous. The analysis assumes data from a randomized parallel group design. We use non-parametric density estimators to construct an ROC curve based on the probabilities that a (non-)responder, defined by better (worse) response to treatment as opposed to control, in the treatment group has a biomarker value above a value c. Our non-parametric approach comes close to the true AUC in a simulation study based on a normal distribution. Application to a real data set shows that despite a significant interaction term in a proportional hazards model, a biomarker may not be helpful for treatment decisions. Our proof-of-principle study opens the door to further developments and generalizations.<\/jats:p>","DOI":"10.3233\/978-1-61499-678-1-745","type":"book-chapter","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:09:19Z","timestamp":1740161359000},"source":"Crossref","is-referenced-by-count":0,"title":["Constructing an ROC Curve to Assess a Treatment-Predictive Continuous Biomarker"],"prefix":"10.3233","author":[{"family":"Engelhardt Alexander","sequence":"additional","affiliation":[]},{"family":"Shen Yu-Ming","sequence":"additional","affiliation":[]},{"family":"Mansmann Ulrich","sequence":"additional","affiliation":[]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Exploring Complexity in Health: An Interdisciplinary Systems Approach"],"original-title":[],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:17:10Z","timestamp":1740161830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospressISBN&isbn=978-1-61499-677-4&spage=745&doi=10.3233\/978-1-61499-678-1-745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/978-1-61499-678-1-745","relation":{},"ISSN":["0926-9630"],"issn-type":[{"value":"0926-9630","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}