{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T05:37:04Z","timestamp":1740202624572,"version":"3.37.3"},"reference-count":0,"publisher":"IOS Press","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>The Artificial Pancreas is a medical device, currently in development, that aims to provide automatic regulation of blood glucose (BG) levels in ambulatory type 1 diabetes mellitus sufferers. The most popular approach utilises subcutaneous (SC) continuous glucose monitoring (CGM) combined with SC insulin injection controlled by a Model Predictive Control (MPC) algorithm. From a safety risk perspective problematic elements include the performance robustness of the CGM and the need for a pre-meal insulin bolus to provide satisfactory post prandial BG regulation. This contribution presents preliminary in silico studies which indicate that the use of an alternative approach to insulin delivery - intra-peritoneal (IP) infusion - could provide a similar level of BG regulation (as obtained with SC delivery), without the need for the pre-meal bolus. This simplified control architecture would remove the patient safety risk related to the administration (or not) of pre-meal bolus.<\/jats:p>","DOI":"10.3233\/978-1-61499-781-8-56","type":"book-chapter","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:46:46Z","timestamp":1740160006000},"source":"Crossref","is-referenced-by-count":0,"title":["The Artificial Pancreas: Reducing Safety Risk via Intra-Peritoneal Insulin Delivery"],"prefix":"10.3233","author":[{"family":"Jones Richard W.","sequence":"additional","affiliation":[]},{"family":"Gianni Francesco","sequence":"additional","affiliation":[]},{"family":"Despotou Georgios","sequence":"additional","affiliation":[]},{"family":"Katzis Konstantinos","sequence":"additional","affiliation":[]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Informatics Empowers Healthcare Transformation"],"original-title":[],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:31:58Z","timestamp":1740162718000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospressISBN&isbn=978-1-61499-780-1&spage=56&doi=10.3233\/978-1-61499-781-8-56"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/978-1-61499-781-8-56","relation":{},"ISSN":["0926-9630"],"issn-type":[{"value":"0926-9630","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]}}}