{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:08:46Z","timestamp":1776092926017,"version":"3.50.1"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643685434","type":"electronic"}],"license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,25]]},"abstract":"<jats:p>Accurate detection of white matter (WM) lesions is essential for diagnosing and monitoring Multiple Sclerosis (MS), but manual lesion identification is challenging and time-consuming. This study employs the \u201cno new U-Net\u201d (nnU-Net) version 2 architecture to enhance the lesion segmentation process. We trained our model with a fine-tuned version of the default nnU-Net configuration incorporating extreme oversampling and a smaller learning rate to improve new or evolving lesion detection. Results showed that our nnU-Net v2 achieved a F1 score of 0.73 for baseline lesions and 0.75 for new or evolving lesions, demonstrating notable performance in identifying both types of lesions, and that the model generalized well to the MSSEG-2 dataset. This study highlights the capabilities of the nnU-Net v2 architecture for robust WM lesion detection in longitudinal cohorts. The final phase involved packaging our top-performing ensemble of models into a Docker container for easy usage, enabling the automatic distinction between baseline and new or evolving lesions.<\/jats:p>","DOI":"10.3233\/faia240420","type":"book-chapter","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T09:48:15Z","timestamp":1727689695000},"source":"Crossref","is-referenced-by-count":4,"title":["Multiclass Lesion Detection Using Longitudinal MRI in Multiple Sclerosis"],"prefix":"10.3233","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8576-7494","authenticated-orcid":false,"given":"Ander","family":"Elkoroaristizabal","sequence":"first","affiliation":[{"name":"e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6409-1197","authenticated-orcid":false,"given":"Francesc","family":"Viv\u00f3","sequence":"additional","affiliation":[{"name":"Neuroimmunology and Multiple Sclerosis Unit, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clinic Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and Universitat de Barcelona, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1953-2803","authenticated-orcid":false,"given":"Albert","family":"Calvi","sequence":"additional","affiliation":[{"name":"Neuroimmunology and Multiple Sclerosis Unit, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clinic Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and Universitat de Barcelona, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7973-2439","authenticated-orcid":false,"given":"Elisabeth","family":"Solana","sequence":"additional","affiliation":[{"name":"Neuroimmunology and Multiple Sclerosis Unit, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clinic Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and Universitat de Barcelona, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2183-8094","authenticated-orcid":false,"given":"Elisabet","family":"Lopez-Soley","sequence":"additional","affiliation":[{"name":"Neuroimmunology and Multiple Sclerosis Unit, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clinic Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and Universitat de Barcelona, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1662-2317","authenticated-orcid":false,"given":"Salut","family":"Alba-Arbalat","sequence":"additional","affiliation":[{"name":"Neuroimmunology and Multiple Sclerosis Unit, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clinic Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and Universitat de Barcelona, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1528-5873","authenticated-orcid":false,"given":"Marcos","family":"Diaz-Hurtado","sequence":"additional","affiliation":[{"name":"e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2443-8800","authenticated-orcid":false,"given":"Baris","family":"Kanber","sequence":"additional","affiliation":[{"name":"Centre for Medical Image Computing, University College London, London, United Kingdom"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-3303","authenticated-orcid":false,"given":"Jordi","family":"Casas-Roma","sequence":"additional","affiliation":[{"name":"e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4273-9121","authenticated-orcid":false,"given":"Sara","family":"Llufriu","sequence":"additional","affiliation":[{"name":"Neuroimmunology and Multiple Sclerosis Unit, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clinic Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and Universitat de Barcelona, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7872-0142","authenticated-orcid":false,"given":"Ferran","family":"Prados","sequence":"additional","affiliation":[{"name":"e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain"},{"name":"Centre for Medical Image Computing, University College London, London, United Kingdom"},{"name":"Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom"},{"name":"National Institute for Health Research Biomedical Research Centre at UCL and UCLH, London, United Kingdom"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9937-3162","authenticated-orcid":false,"given":"Eloy","family":"Mart\u00ednez-Heras","sequence":"additional","affiliation":[{"name":"Neuroimmunology and Multiple Sclerosis Unit, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clinic Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and Universitat de Barcelona, Barcelona, Spain"}]}],"member":"7437","container-title":["Frontiers in Artificial Intelligence and Applications","Artificial Intelligence Research and 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