{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T19:01:33Z","timestamp":1777748493296,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"1-2","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISB"],"published-print":{"date-parts":[[2021,5,28]]},"abstract":"<jats:p>To develop vaccines it is mandatory yet challenging to account for inter-individual variability during immune responses. Even in laboratory mice, T cell responses of single individuals exhibit a high heterogeneity that may come from genetic backgrounds, intra-specific processes (e.g. antigen-processing and presentation) and immunization\u00a0protocols. To account for inter-individual variability in CD8 T cell responses in mice, we propose a dynamical model coupled to a statistical, nonlinear mixed effects model. Average and individual dynamics during a CD8 T cell response are characterized in different immunization contexts (vaccinia virus and tumor). On one hand, we identify biological processes that generate inter-individual variability (activation rate of naive cells, the mortality rate of effector cells, and dynamics of the immunogen). On the other hand, introducing categorical covariates to analyze two different immunization regimens, we highlight the steps of the response impacted by immunogens (priming, differentiation of naive cells, expansion of effector cells and generation of memory cells). The robustness of the model is assessed by confrontation to new experimental\u00a0data. Our approach allows to investigate immune responses in various immunization contexts, when measurements are scarce or missing, and contributes to a better understanding of inter-individual variability in CD8 T cell immune\u00a0responses.<\/jats:p>","DOI":"10.3233\/isb-200205","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T03:42:42Z","timestamp":1612755762000},"page":"13-39","source":"Crossref","is-referenced-by-count":4,"title":["Modeling and characterization of inter-individual variability in CD8 T cell responses in mice"],"prefix":"10.1177","volume":"14","author":[{"given":"Chloe","family":"Audebert","sequence":"first","affiliation":[{"name":"Inria Dracula, Villeurbanne, France"},{"name":"Sorbonne Universit\u00e9, CNRS, Universit\u00e9 de Paris, Laboratoire Jacques-Louis Lions UMR 7598, F-75005 Paris, France"},{"name":"Sorbonne Universit\u00e9, CNRS, Institut de biologie Paris-Seine (IBPS), Laboratoire de Biologie Computationnelle et Quantitative UMR 7238, F-75005 Paris, France"}]},{"given":"Daphn\u00e9","family":"Laubreton","sequence":"additional","affiliation":[{"name":"Centre International de recherche en Infectiologie, Universit\u00e9 de Lyon, INSERM U1111, CNRS UMR 5308, Ecole Normale Sup\u00e9rieure de Lyon, Universit\u00e9 Claude Bernard Lyon 1, 69007 Lyon, France"}]},{"given":"Christophe","family":"Arpin","sequence":"additional","affiliation":[{"name":"Centre International de recherche en Infectiologie, Universit\u00e9 de Lyon, INSERM U1111, CNRS UMR 5308, Ecole Normale Sup\u00e9rieure de Lyon, Universit\u00e9 Claude Bernard Lyon 1, 69007 Lyon, France"}]},{"given":"Olivier","family":"Gandrillon","sequence":"additional","affiliation":[{"name":"Inria Dracula, Villeurbanne, France"},{"name":"Laboratory of Biology and Modelling of the Cell, Universit\u00e9 de Lyon, ENS de Lyon, Universit\u00e9 Claude Bernard, CNRS UMR 5239, INSERM U1210, 69007 Lyon, France"}]},{"given":"Jacqueline","family":"Marvel","sequence":"additional","affiliation":[{"name":"Centre International de recherche en Infectiologie, Universit\u00e9 de Lyon, INSERM U1111, CNRS UMR 5308, Ecole Normale Sup\u00e9rieure de Lyon, Universit\u00e9 Claude Bernard Lyon 1, 69007 Lyon, France"}]},{"given":"Fabien","family":"Crauste","sequence":"additional","affiliation":[{"name":"Inria Dracula, Villeurbanne, France"},{"name":"Universit\u00e9 de Paris, MAP5, CNRS, F-75006, France"}]}],"member":"179","reference":[{"key":"10.3233\/ISB-200205_ref1","doi-asserted-by":"crossref","first-page":"eaah5861","DOI":"10.1126\/sciimmunol.aah5861","article-title":"Primary immunodeficiencies suggest redundancy within the human immune system","volume":"1","author":"Fischer","year":"2016","journal-title":"Sci Immunol"},{"key":"10.3233\/ISB-200205_ref2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.smim.2017.12.009","article-title":"Robust control of the adaptive immune 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