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The proposed approach considers the surroundings (organs and bone marrow) and the different subsystems (cells and cyctokines). The interactions between blood cells, cytokines and the surroundings are described via mass balances. Cytokines are adsorbed onto associated receptors at the cell surface. The adsorption is described by the Langmuir model and gives rise to the production of more cytokines and associated receptors inside the cell. The quantities of pro and anti-inflammatory cytokines present in the body are combined to give global information via an inflammation level function which describes the patient\u2019s state. Data for parameter estimation comes from the Sepsis 48\u200aH database. Comparisons between patient data and simulations are presented and are in good agreement. For the IL18\/IL10 cytokine pair, 5 key parameters have been found. They are linked to pro-inflammatory IL18 cytokine and show that the early sepsis is driven by components of inflammatory character.<\/jats:p>","DOI":"10.3233\/isb-200474","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T11:01:38Z","timestamp":1592910098000},"page":"101-121","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Dynamical modeling of pro- and anti-inflammatory cytokines in the early stage           of septic shock"],"prefix":"10.1177","volume":"13","author":[{"given":"J.","family":"Tallon","sequence":"first","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon 1,\r          CNRS, LAGEPP UMR 5007, Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Browning","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon 1,\r          CNRS, LAGEPP UMR 5007, Villeurbanne, 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