{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T19:00:39Z","timestamp":1777748439579,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"3-4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["In Silico Biology: Journal of Biological Systems Modeling and Multi-Scale Simulation"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>Under physiological conditions, many proteins that include a region lacking well-defined three-dimensional structures have been identified, especially in eukaryotes. These regions often play an important biological cellular role, although they cannot form a stable structure. Therefore, they are biologically remarkable phenomena. From an industrial perspective, they can provide useful information for determining three-dimensional structures or designing drugs. For these reasons, disordered regions have attracted a great deal of attention in recent years. Their accurate prediction is therefore anticipated to provide annotations that are useful for wide range of applications.<\/jats:p>\n                  <jats:p>POODLE-I (where \"I\" stands for integration) is a web-based disordered region prediction system. POODLE-I integrates prediction results obtained from three kinds of disordered region predictors (POODLEs) developed from the viewpoint that the characteristics of disordered regions change according to their length. Furthermore, POODLE-I combines that information with predicted structural information by application of a workflow approach. When compared with server teams that showed best performance in CASP8, POODLE-I ranked among the top and exhibited the highest performance in predicting unfolded proteins.<\/jats:p>\n                  <jats:p>POODLE-I is an efficient tool for detecting disordered regions in proteins solely from the amino acid sequence. The application is freely available at http:\/\/mbs.cbrc.jp\/poodle\/poodle-i.html.<\/jats:p>","DOI":"10.3233\/isb-2010-0426","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T22:47:22Z","timestamp":1575326842000},"page":"185-191","source":"Crossref","is-referenced-by-count":17,"title":["POODLE-I: Disordered Region Prediction by Integrating POODLE \t\t\t Series and Structural Information Predictors Based on a Workflow Approach"],"prefix":"10.1177","volume":"10","author":[{"given":"Shuichi","family":"Hirose","sequence":"first","affiliation":[{"name":"Computational Biology Research Center (CBRC), National\r\t\t\t Institute of Advanced Industrial Science and Technology (AIST), Tokyo,\r\t\t\t Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Computational Biology Research Center (CBRC), National\r\t\t\t Institute of Advanced Industrial Science and Technology (AIST), Tokyo,\r\t\t\t Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamotsu","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Computational Biology Research Center (CBRC), National\r\t\t\t Institute of Advanced Industrial Science and Technology (AIST), Tokyo,\r\t\t\t Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,1,1]]},"container-title":["In Silico Biology: Journal of Biological Systems Modeling and Multi-Scale Simulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/ISB-2010-0426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/ISB-2010-0426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:49:15Z","timestamp":1777463355000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/ISB-2010-0426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,1]]},"references-count":0,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.3233\/ISB-2010-0426"],"URL":"https:\/\/doi.org\/10.3233\/isb-2010-0426","relation":{"is-cited-by":[{"id-type":"doi","id":"10.1007\/978-1-4939-3572-7_14","asserted-by":"object"}]},"ISSN":["1386-6338","1434-3207"],"issn-type":[{"value":"1386-6338","type":"print"},{"value":"1434-3207","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,1]]}}}