{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T19:01:37Z","timestamp":1777748497332,"version":"3.51.4"},"reference-count":102,"publisher":"SAGE Publications","issue":"3-4","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISB"],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:p>Large-scale visualization and analysis of HPIs involved in microbial CVDs can provide crucial insights into the mechanisms of pathogenicity. The comparison of CVD associated HPIs with the entire set of HPIs can identify the pathways specific to CVDs. Therefore, topological properties of HPI networks in CVDs and all pathogens was studied using Cytoscape3.5.1. Ontology and pathway analysis were done using KOBAS 3.0. HPIs of Papilloma, Herpes, Influenza A virus as well as Yersinia pestis and Bacillus anthracis among bacteria were predominant in the whole (wHPI) and the CVD specific (cHPI) network. The central viral and secretory bacterial proteins were predicted virulent. The central viral proteins had higher number of interactions with host proteins in comparison with bacteria. Major fraction of central and essential host proteins interacts with central viral proteins. Alpha-synuclein, Ubiquitin ribosomal proteins, TATA-box-binding protein, and Polyubiquitin-C &amp;B proteins were the top interacting proteins specific to CVDs. Signaling by NGF, Fc epsilon receptor, EGFR and ubiquitin mediated proteolysis were among the top enriched CVD specific pathways. DEXDc and HELICc were enriched host mimicry domains that may help in hijacking of cellular machinery by pathogens. This study provides a system level understanding of cardiac damage in microbe induced CVDs.<\/jats:p>","DOI":"10.3233\/isb-210238","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T11:42:08Z","timestamp":1641296528000},"page":"115-133","source":"Crossref","is-referenced-by-count":2,"title":["Network analysis of host-pathogen protein interactions in microbe induced cardiovascular diseases"],"prefix":"10.1177","volume":"14","author":[{"given":"Nirupma","family":"Singh","sequence":"first","affiliation":[{"name":"Computational and Structural Biology Laboratory, Department of Biotechnology, Netaji Subhas Institute of Technology, Dwarka, New Delhi, India"}]},{"given":"Sneha","family":"Rai","sequence":"additional","affiliation":[{"name":"Computational and Structural Biology Laboratory, Department of Biotechnology, Netaji Subhas Institute of Technology, Dwarka, New Delhi, India"}]},{"given":"Rakesh","family":"Bhatnagar","sequence":"additional","affiliation":[{"name":"Amity University, Jaipur, Rajasthan, India"}]},{"given":"Sonika","family":"Bhatnagar","sequence":"additional","affiliation":[{"name":"Computational and Structural Biology Laboratory, Department of Biotechnology, Netaji Subhas Institute of Technology, Dwarka, New Delhi, India"},{"name":"Computational and Structural Biology Laboratory, Department of Biological Sciences and Engineering, Netaji Subhas University of Technology, Dwarka, New Delhi, India"}]}],"member":"179","reference":[{"issue":"11","key":"10.3233\/ISB-210238_ref1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1021\/acsinfecdis.6b00182","article-title":"Taking Aim at Host\u2013Pathogen Interactions","volume":"2","author":"Pezacki","year":"2016","journal-title":"ACS Infectious Diseases"},{"issue":"1","key":"10.3233\/ISB-210238_ref2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12929-019-0540-y","article-title":"Recent advances on the role of host factors during non-poliovirus enteroviral infections","volume":"26","author":"Owino","year":"2019","journal-title":"Journal of Biomedical Science"},{"issue":"2","key":"10.3233\/ISB-210238_ref3","doi-asserted-by":"crossref","first-page":"1230001","DOI":"10.1142\/S0219720012300018","article-title":"Progress in computational studies of host-pathogen interactions","volume":"11","author":"Zhou","year":"2013","journal-title":"J Bioinform Comput Biol"},{"issue":"5","key":"10.3233\/ISB-210238_ref4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.arcmed.2015.05.006","article-title":"Infection and Atherosclerosis Development","volume":"46","author":"Campbell","year":"2015","journal-title":"Arch Med Res"},{"issue":"11","key":"10.3233\/ISB-210238_ref5","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1161\/01.CIR.96.11.4095","article-title":"Roles of infectious agents in atherosclerosis and restenosis: an assessment of the evidence and need for future research","volume":"96","author":"Libby","year":"1997","journal-title":"Circulation"},{"issue":"2","key":"10.3233\/ISB-210238_ref6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0733-8651(05)70074-6","article-title":"Plaque disruption and thrombosis","volume":"17","author":"Shah","year":"1999","journal-title":"Cardiology Clinics"},{"issue":"3","key":"10.3233\/ISB-210238_ref7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1161\/01.ATV.18.3.339","article-title":"Herpesviruses in Atherosclerosis and Thrombosis [10.\/01.ATV.18.3.339]","volume":"18","author":"Nicholson","year":"1998","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"1","key":"10.3233\/ISB-210238_ref8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1373\/clinchem.2018.287318","article-title":"Cardiovascular Disease and Frailty: What Are the Mechanistic Links?","volume":"65","author":"Stewart","year":"2019","journal-title":"Clinical Chemistry"},{"key":"10.3233\/ISB-210238_ref9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrmicro.2017.149","article-title":"Microbial modulation of cardiovascular disease [Review Article]","volume":"16","author":"Brown","year":"2018","journal-title":"Nature Reviews Microbiology"},{"issue":"41","key":"10.3233\/ISB-210238_ref10","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.3748\/wjg.v24.i41.4617","article-title":"Chronic hepatitis C, atherosclerosis and cardiovascular disease: What impact of direct-acting antiviral treatments?","volume":"24","author":"Adinolfi","year":"2018","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.3233\/ISB-210238_ref11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11904-016-0301-4","article-title":"Recent Insights Into Cardiovascular Disease (CVD) Risk Among HIV-Infected Adults","volume":"13","author":"Kaplan","year":"2016","journal-title":"Current HIV\/AIDS Reports"},{"key":"10.3233\/ISB-210238_ref12","unstructured":"Cardiology ACo. 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