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Despite the reality that many patients participate in clinical trials in conjunction with standard medical care, only recently have efforts extended to address and improve the health literacy of both clinical trial researchers and participants. To date, the primary focus of health literacy activities in clinical trials has centered on communicating trial results to trial participants. This report describes the opportunities and strategies necessary to layer health literacy activities across the clinical trial process from consent to conclusion.<\/jats:p>","DOI":"10.3233\/isu-200082","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T15:22:08Z","timestamp":1603812128000},"page":"41-49","source":"Crossref","is-referenced-by-count":0,"title":["How health literacy can enhance the design and conduct of clinical trials from consent to conclusion"],"prefix":"10.1177","volume":"40","author":[{"given":"Catina","family":"O\u2019Leary","sequence":"first","affiliation":[{"name":", , , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Casey","sequence":"additional","affiliation":[{"name":", , , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Webb","sequence":"additional","affiliation":[{"name":", , , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Collyar","sequence":"additional","affiliation":[{"name":", , , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Pleasant","sequence":"additional","affiliation":[{"name":", , , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/ISU-200082_ref1","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1056\/NEJMp1407373","article-title":"Public trust in physicians \u2013 U.S. medicine in international perspective","volume":"371","author":"Blendon","year":"2014","journal-title":"New Engl J Med"},{"key":"10.3233\/ISU-200082_ref2","doi-asserted-by":"publisher","DOI":"10.31478\/201604a","volume-title":"Considerations for a New Definition of Health Literacy","author":"Pleasant","year":"2016"},{"issue":"9","key":"10.3233\/ISU-200082_ref3","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1056\/NEJMsa1012065","article-title":"The ClinicalTrials.gov results database\u2013update and key issues","volume":"364","author":"Zarin","year":"2011","journal-title":"New Engl J Med"},{"key":"10.3233\/ISU-200082_ref4","volume-title":"Health Literacy Principles: Guidance for Making Information Understandable, Useful, and Navigable","author":"Jacobson","year":"2014"},{"key":"10.3233\/ISU-200082_ref5","unstructured":"The Health Literacy Style Manual MAXIMUS Center for Health Literacy, 2005, http:\/\/www.coveringkidsandfamilies.org\/resources\/docs\/stylemanual.pdf."},{"key":"10.3233\/ISU-200082_ref6","volume-title":"PRISM Readability Toolkit","author":"Ridpath","year":"2007"},{"issue":"1 suppl","key":"10.3233\/ISU-200082_ref7","doi-asserted-by":"publisher","first-page":"37S","DOI":"10.1177\/1077558712458541","article-title":"The right tool is what they need, not what we have: A taxonomy of appropriate levels of precision in patient risk communication","volume":"70","author":"Zikmund-Fisher","year":"2013","journal-title":"Medical Care Research and Review"},{"issue":"8","key":"10.3233\/ISU-200082_ref8","first-page":"639","article-title":"SMOG grading: A new readability formula","volume":"12","author":"McLaughlin","year":"1969","journal-title":"Journal of Reading"},{"key":"10.3233\/ISU-200082_ref9","first-page":"483","volume-title":"The Health Literacy of America\u2019s Adults: Results from the 2003 National Assessment of Adult Literacy. 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