{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T22:47:10Z","timestamp":1776811630637,"version":"3.51.2"},"reference-count":50,"publisher":"European Society of Computational Methods in Sciences and Engineering","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"published-print":{"date-parts":[[2022,3,28]]},"abstract":"<jats:p>The main objective of this review was to explore the research foci and emerging trends of application of natural products in AD from 1990 to 2019 and evaluated publications qualitatively and quantitatively. CiteSpace V. 4.0 was used to identify top authors, journals, institutions, countries, keywords, co-cited articles, and trends and obtain the visual knowledge maps. Results revealed that the USA, People\u2019s Republic of China and India were the major research countries in this field, while the Western Europe and North America were the areas with frequent international cooperation. Moreover, there was a close collaboration between universities and research institutes. The J Alzheimers Dis was the most productive journal. Alzheimers disease, natural product, brain, central nervous system, disease, and oxidative stress are some of the high centrality and high frequency keywords in the co-occurrence analysis; Indicating Alzheimers disease and its pathogenesis and natural product remain the hotspots in the field. This paper provides an insight into the application of natural products in AD, and provides useful information for AD researchers to find potential collaborators and cooperative institutions.<\/jats:p>","DOI":"10.3233\/jcm-215870","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T17:00:30Z","timestamp":1638291630000},"page":"649-659","source":"Crossref","is-referenced-by-count":0,"title":["Emerging evolution trends of application of natural products in Alzheimer\u2019s disease"],"prefix":"10.66113","volume":"22","author":[{"given":"Xuemei","family":"Wang","sequence":"first","affiliation":[{"name":"Yan\u2019an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan\u2019an University, Yan\u2019an, Shaanxi, China"},{"name":"Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, Yan\u2019an University, Yan\u2019an, Shaanxi, China"},{"name":"Yan\u2019an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan\u2019an University, Yan\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueli","family":"Li","sequence":"additional","affiliation":[{"name":"Yan\u2019an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan\u2019an University, Yan\u2019an, Shaanxi, China"},{"name":"Shaanxi Key Laboratory of Chemical Reaction Engineering, College of Chemistry and Chemical Engineering, Yan\u2019an University, Yan\u2019an, Shaanxi, China"},{"name":"Yan\u2019an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan\u2019an University, Yan\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shaoxing Hospital, Shaoxing People\u2019s Hospital, Zhejiang University School of Medicine, Shaoxing, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruirui","family":"Guo","sequence":"additional","affiliation":[{"name":"Yan\u2019an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan\u2019an University, Yan\u2019an, Shaanxi, China"},{"name":"Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, Yan\u2019an University, Yan\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Sun","sequence":"additional","affiliation":[{"name":"Yan\u2019an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan\u2019an University, Yan\u2019an, Shaanxi, China"},{"name":"Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, Yan\u2019an University, Yan\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Sun","sequence":"additional","affiliation":[{"name":"Yan\u2019an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan\u2019an University, Yan\u2019an, Shaanxi, China"},{"name":"Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, Yan\u2019an University, Yan\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zexin","family":"Li","sequence":"additional","affiliation":[{"name":"Yan\u2019an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan\u2019an University, Yan\u2019an, Shaanxi, China"},{"name":"Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, Yan\u2019an University, Yan\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Yan\u2019an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan\u2019an University, Yan\u2019an, Shaanxi, China"},{"name":"Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, Yan\u2019an University, Yan\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changwu","family":"Yue","sequence":"additional","affiliation":[{"name":"Yan\u2019an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan\u2019an University, Yan\u2019an, Shaanxi, China"},{"name":"Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, Yan\u2019an University, Yan\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Lyu","sequence":"additional","affiliation":[{"name":"Yan\u2019an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan\u2019an University, Yan\u2019an, Shaanxi, China"},{"name":"Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, Yan\u2019an University, Yan\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"55691","reference":[{"issue":"106","key":"10.3233\/JCM-215870_ref1","first-page":"1","article-title":"The age factor in Alzheimer\u2019s disease","volume":"7","author":"Guerreiro","year":"2015","journal-title":"Genome Med"},{"issue":"1","key":"10.3233\/JCM-215870_ref2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer\u2019s disease","volume":"25","author":"Lane","year":"2018","journal-title":"Eur J Neurol"},{"issue":"2","key":"10.3233\/JCM-215870_ref3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.mcna.2018.10.009","article-title":"The alzheimer\u2019s disease clinical spectrum: Diagnosis and management","volume":"103","author":"Atri","year":"2019","journal-title":"Med Clin North Am"},{"key":"10.3233\/JCM-215870_ref4","doi-asserted-by":"crossref","unstructured":"2016 Alzheimer\u2019s disease facts and figures, Alzheimers Dement 12(4) (2016), 459\u2013509.","DOI":"10.1016\/j.jalz.2016.03.001"},{"issue":"7","key":"10.3233\/JCM-215870_ref5","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S1474-4422(16)30047-3","article-title":"Finding a cure for Alzheimer\u2019s disease starts with prevention","volume":"15","author":"Neurology","year":"2016","journal-title":"Lancet Neurol"},{"issue":"2","key":"10.3233\/JCM-215870_ref6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1212\/WNL.0000000000006745","article-title":"Translating the biology of aging into novel therapeutics for Alzheimer disease","volume":"92","author":"Hara","year":"2019","journal-title":"Neurology"},{"issue":"2","key":"10.3233\/JCM-215870_ref8","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.biotechadv.2016.12.005","article-title":"Natural products against Alzheimer\u2019s disease: Pharmaco-therapeutics and biotechnological interventions","volume":"35","author":"Dey","year":"2017","journal-title":"Biotechnol Adv"},{"key":"10.3233\/JCM-215870_ref9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev-neuro-070815-014015","article-title":"Alzheimer\u2019s disease mechanisms and emerging roads to novel therapeutics","volume":"39","author":"Frigerio","year":"2016","journal-title":"Annu Rev Neurosci"},{"issue":"1","key":"10.3233\/JCM-215870_ref10","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s12035-018-1092-y","article-title":"Could alzheimer\u2019s disease originate in the periphery and if so how so","volume":"56","author":"Morris","year":"2019","journal-title":"Mol Neurobiol"},{"key":"10.3233\/JCM-215870_ref11","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.2147\/IJN.S200490","article-title":"Nair M., Alzheimer\u2019s disease: Pathogenesis, diagnostics, and therapeutics","volume":"14","author":"Tiwari","year":"2019","journal-title":"Int J Nanomedicine"},{"issue":"10061","key":"10.3233\/JCM-215870_ref12","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1016\/S0140-6736(16)32457-6","article-title":"Alzheimer\u2019s disease: expedition into the unknown","volume":"388","author":"Lancet","year":"2016","journal-title":"Lancet"},{"key":"10.3233\/JCM-215870_ref13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12916-015-0297-4","article-title":"Advances in Alzheimer\u2019s disease drug development","volume":"13","author":"Rafii","year":"2015","journal-title":"Bmc Med"},{"issue":"9","key":"10.3233\/JCM-215870_ref14","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1517\/17460441.2014.930124","article-title":"Epigenetic drug discovery for Alzheimer\u2019s disease","volume":"9","author":"Cacabelos","year":"2014","journal-title":"Expert Opin Drug Discov"},{"issue":"3","key":"10.3233\/JCM-215870_ref15","first-page":"CD001747","article-title":"Galantamine for Alzheimer\u2019s disease","author":"Olin","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"10.3233\/JCM-215870_ref16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7861\/clinmedicine.16-3-247","article-title":"Drug treatments in Alzheimer\u2019s disease","volume":"16","author":"Briggs","year":"2016","journal-title":"Clin Med (Lond)"},{"issue":"1","key":"10.3233\/JCM-215870_ref17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2478\/AMNS.2019.1.00009","article-title":"Can aphids be controlled by fungus? A mathematical model","volume":"4","author":"Britton","year":"2019","journal-title":"Applied Mathematics and Nonlinear Sciences"},{"issue":"3","key":"10.3233\/JCM-215870_ref18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2174\/1568026619666190201153257","article-title":"Small Molecule Natural Products and Alzheimer\u2019s Disease","volume":"19","author":"Wu","year":"2019","journal-title":"Curr Top Med Chem"},{"issue":"16","key":"10.3233\/JCM-215870_ref19","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1001\/jama.1997.03550160047037","article-title":"A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group","volume":"278","author":"Le","year":"1997","journal-title":"JAMA"},{"issue":"7","key":"10.3233\/JCM-215870_ref20","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1136\/jnnp.74.7.863","article-title":"Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer\u2019s disease: a double blind, randomised, placebo controlled trial","volume":"74","author":"Akhondzadeh","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"10.3233\/JCM-215870_ref21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1365-2710.2003.00463.x","article-title":"Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer\u2019s disease: a double blind, randomized and placebo-controlled trial","volume":"28","author":"Akhondzadeh","year":"2003","journal-title":"J Clin Pharm Ther"},{"issue":"5","key":"10.3233\/JCM-215870_ref22","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1021\/acschemneuro.5b00013","article-title":"Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitro","volume":"6","author":"Paranjape","year":"2015","journal-title":"Acs Chem Neurosci"},{"issue":"5","key":"10.3233\/JCM-215870_ref23","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1517\/14712598.2012.674507","article-title":"Emerging trends in regenerative medicine: a scientometric analysis in CiteSpace","volume":"12","author":"Chen","year":"2012","journal-title":"Expert Opin Biol Ther"},{"key":"10.3233\/JCM-215870_ref24","doi-asserted-by":"crossref","first-page":"951","DOI":"10.2147\/JPR.S132808","article-title":"Study of acupuncture for low back pain in recent 20 years: a bibliometric analysis via CiteSpace","volume":"10","author":"Liang","year":"2017","journal-title":"J Pain Res"},{"key":"10.3233\/JCM-215870_ref25","first-page":"357","article-title":"Visualization analysis of research hotspots based on CiteSpace II: taking medical devices as an example","volume":"7","author":"Liu","year":"2014","journal-title":"Med Devices (Auckl)"},{"key":"10.3233\/JCM-215870_ref26","first-page":"637","article-title":"Heavy metal loss from agricultural watershed to aquatic system: A scientometrics review","author":"Ouyang","year":"2018","journal-title":"Sci Total Environ"},{"issue":"21","key":"10.3233\/JCM-215870_ref27","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/0024-3205(90)90429-U","article-title":"Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo","volume":"46","author":"Thomsen","year":"1990","journal-title":"Life Sci"},{"key":"10.3233\/JCM-215870_ref28","unstructured":"M.B. Synnestvedt, C. Chen and J.H. Holmes, CiteSpace II: visualization sand knowledge discovery in bibliographic databases, AMIA Annu Symp Proc (2005), 724\u2013728."},{"issue":"6","key":"10.3233\/JCM-215870_ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/21645515.2017.1286433","article-title":"Emerging trends and new developments in monoclonal antibodies: A scientometric analysis (1980\u20132016)","volume":"13","author":"Lai","year":"2017","journal-title":"Hum Vaccin Immunother"},{"issue":"6","key":"10.3233\/JCM-215870_ref30","first-page":"630","article-title":"Application of visualization on emerging infectious disease based on CiteSpace II","volume":"33","author":"Chen","year":"2012","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"10.3233\/JCM-215870_ref31","doi-asserted-by":"crossref","unstructured":"L. Wang, X. Xue, Y. Zhang et al., Exploring the Emerging Evolution Trends of Urban Resilience Research by Scientometric Analysis, Int J Environ Res Public Health 15(10) (2018).","DOI":"10.3390\/ijerph15102181"},{"issue":"9\u201310","key":"10.3233\/JCM-215870_ref32","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1017\/S135561771700100X","article-title":"Alzheimer\u2019s Disease: Past, Present, and Future","volume":"23","author":"Bondi","year":"2017","journal-title":"J Int Neuropsychol Soc"},{"issue":"12","key":"10.3233\/JCM-215870_ref33","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1517\/14656566.2.12.2027","article-title":"Current status and new developments with galantamine in the treatment of Alzheimer\u2019s disease","volume":"2","author":"Tariot","year":"2001","journal-title":"Expert Opin Pharmacother"},{"issue":"3","key":"10.3233\/JCM-215870_ref34","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1017\/S026646230200034X","article-title":"Clinical and cost-effectiveness of donepezil, rivastigmine, and galantamine for Alzheimer\u2019s disease. A systematic review","volume":"18","author":"Clegg","year":"2002","journal-title":"Int J Technol Assess Health Care"},{"issue":"2","key":"10.3233\/JCM-215870_ref35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1586\/14737175.4.2.153","article-title":"Galantamine: use in Alzheimer\u2019s disease and related disorders","volume":"4","author":"Bullock","year":"2004","journal-title":"Expert Rev Neurother"},{"issue":"2","key":"10.3233\/JCM-215870_ref36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.31887\/DCNS.2009.11.2\/cqiu","article-title":"Epidemiology of Alzheimer\u2019s disease: occurrence, determinants, and strategies toward intervention","volume":"11","author":"Qiu","year":"2009","journal-title":"Dialogues Clin Neurosci"},{"issue":"8","key":"10.3233\/JCM-215870_ref37","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.arcmed.2012.09.008","article-title":"Physical activity, brain plasticity, and Alzheimer\u2019s disease","volume":"43","author":"Erickson","year":"2012","journal-title":"Arch Med Res"},{"issue":"9","key":"10.3233\/JCM-215870_ref38","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S1474-4422(08)70169-8","article-title":"Alzheimer\u2019s disease and vascular dementia in developing countries: prevalence, management, and risk factors","volume":"7","author":"Kalaria","year":"2008","journal-title":"Lancet Neurol"},{"issue":"10","key":"10.3233\/JCM-215870_ref39","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.jval.2019.04.1937","article-title":"A real-world evidence analysis of associations among costs, quality of life, and disease-severity indicators of alzheimer\u2019s disease in Thailand","volume":"22","author":"Kongpakwattana","year":"2019","journal-title":"Value Health"},{"issue":"47","key":"10.3233\/JCM-215870_ref40","doi-asserted-by":"crossref","first-page":"83114","DOI":"10.18632\/oncotarget.20851","article-title":"Trends of long noncoding RNA research from 2007 to 2016: a bibliometric analysis","volume":"8","author":"Miao","year":"2017","journal-title":"Oncotarget"},{"key":"10.3233\/JCM-215870_ref41","doi-asserted-by":"crossref","unstructured":"X. Ma, L. Zhang, J. Wang et al., Knowledge Domain and Emerging Trends on Echinococcosis Research: A Scientometric Analysis, Int J Environ Res Public Health 16(5) (2019).","DOI":"10.3390\/ijerph16050842"},{"issue":"12","key":"10.3233\/JCM-215870_ref42","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.tips.2006.10.004","article-title":"Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease","volume":"27","author":"Zhang","year":"2006","journal-title":"Trends Pharmacol Sci"},{"issue":"6","key":"10.3233\/JCM-215870_ref43","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1007\/s11356-018-04090-1","article-title":"Dynamic analysis of international green behavior from the perspective of the mapping knowledge domain","volume":"26","author":"Li","year":"2019","journal-title":"Environ Sci Pollut Res Int"},{"issue":"17","key":"10.3233\/JCM-215870_ref44","doi-asserted-by":"crossref","first-page":"17809","DOI":"10.1007\/s11356-019-05071-8","article-title":"Global trends and future prospects of e-waste research: a bibliometric analysis","volume":"26","author":"Gao","year":"2019","journal-title":"Environ Sci Pollut Res Int"},{"key":"10.3233\/JCM-215870_ref45","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3389\/fphar.2019.00246","article-title":"Trends and development in enteral nutrition application for ventilator associated pneumonia: A scientometric research study (1996\u20132018)","volume":"10","author":"Chen","year":"2019","journal-title":"Front Pharmacol"},{"issue":"4","key":"10.3233\/JCM-215870_ref46","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3233\/JAD-170045","article-title":"Mouse Models of Alzheimer\u2019s Disease","volume":"57","author":"Esquerda-Canals","year":"2017","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"10.3233\/JCM-215870_ref47","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1570159X13666150716165726","article-title":"Alzheimer\u2019s disease: Targeting the Cholinergic System","volume":"14","author":"Ferreira-Vieira","year":"2016","journal-title":"Curr Neuropharmacol"},{"issue":"4","key":"10.3233\/JCM-215870_ref48","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2174\/1567205014666170829100230","article-title":"The phosphoinositide signal transduction pathway in the pathogenesis of alzheimer\u2019s disease","volume":"15","author":"Lo","year":"2018","journal-title":"Curr Alzheimer Res"},{"issue":"12","key":"10.3233\/JCM-215870_ref49","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2174\/1568026618666180821145215","article-title":"Parallelization of Molecular Docking: A Review","volume":"18","author":"Dong","year":"2018","journal-title":"Curr Top Med Chem"},{"key":"10.3233\/JCM-215870_ref50","doi-asserted-by":"crossref","first-page":"8357","DOI":"10.12659\/MSM.913644","article-title":"Scientometric Analysis of SIRT6 Studies","volume":"24","author":"Lu","year":"2018","journal-title":"Med Sci Monit"},{"issue":"1","key":"10.3233\/JCM-215870_ref51","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1037\/per0000268","article-title":"Personality and Alzheimer\u2019s disease: An integrative review","volume":"10","author":"Terracciano","year":"2019","journal-title":"Personal Disord"}],"container-title":["Journal of Computational Methods in Sciences and Engineering"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JCM-215870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T22:06:46Z","timestamp":1776809206000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JCM-215870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,28]]},"references-count":50,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jcm-215870","relation":{},"ISSN":["1472-7978","1875-8983"],"issn-type":[{"value":"1472-7978","type":"print"},{"value":"1875-8983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,28]]}}}