{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T12:50:00Z","timestamp":1755694200075},"reference-count":0,"publisher":"IOS Press","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,27]]},"abstract":"<jats:p>cBioPortal is a commonly used data warehousing solution for genomic cancer studies. The software is being extended for patient care application in a molecular tumor board by the MIRACUM consortium within the Medical Informatics Initiative Germany. A key feature for this use case is the ability to enter therapy recommendations for individual patients, which requires interoperability with the hospital information system. A RESTful interface between cBioPortal and an external mediation layer was selected from the different implementation options. It achieves interoperability by using a FHIR capable server to store data and applying the HL7 FHIR Genomics Reporting implementation guide. For systems not supporting the FHIR standard, the well-established HL7 Version 2 standard is available as a fallback export format.<\/jats:p>","DOI":"10.3233\/shti210169","type":"book-chapter","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T12:58:18Z","timestamp":1622120298000},"source":"Crossref","is-referenced-by-count":7,"title":["FhirSpark \u2013 Implementing a Mediation Layer to Bring FHIR to the cBioPortal for Cancer Genomics"],"prefix":"10.3233","author":[{"given":"Niklas","family":"Reimer","sequence":"first","affiliation":[{"name":"Group for Medical Systems Biology, L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck, Germany"}]},{"given":"Philipp","family":"Unberath","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}]},{"given":"Hauke","family":"Busch","sequence":"additional","affiliation":[{"name":"Group for Medical Systems Biology, L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck, Germany"}]},{"given":"Josef","family":"Ingenerf","sequence":"additional","affiliation":[{"name":"IT Center for Clinical Research, University of L\u00fcbeck, Germany"},{"name":"Institute of Medical Informatics, University of L\u00fcbeck, Germany"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Public Health and Informatics"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI210169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T13:11:48Z","timestamp":1635167508000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI210169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,27]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti210169","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,27]]}}}