{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T10:15:41Z","timestamp":1654596941352},"reference-count":0,"publisher":"IOS Press","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,6]]},"abstract":"<jats:p>We present an automated knowledge synthesis and discovery framework to analyze published literature to identify and represent underlying mechanistic associations that aggravate chronic conditions due to COVID-19. Our literature-based discovery approach integrates text mining, knowledge graphs and medical ontologies to discover hidden and previously unknown pathophysiologic relations, dispersed across multiple public literature databases, between COVID-19 and chronic disease mechanisms. We applied our approach to discover mechanistic associations between COVID-19 and chronic conditions\u2014i.e. diabetes mellitus and chronic kidney disease\u2014to understand the long-term impact of COVID-19 on patients with chronic diseases. We found several gene-disease associations that could help identify mechanisms driving poor outcomes for COVID-19 patients with underlying conditions.<\/jats:p>","DOI":"10.3233\/shti220084","type":"book-chapter","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T09:31:28Z","timestamp":1654594288000},"source":"Crossref","is-referenced-by-count":0,"title":["A Knowledge Graph of Mechanistic Associations Between COVID-19, Diabetes Mellitus, and Chronic Kidney Disease"],"prefix":"10.3233","author":[{"given":"Michael","family":"Barrett","sequence":"first","affiliation":[{"name":"NICHE Research Group, Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Sibte Raza","family":"Abidi","sequence":"additional","affiliation":[{"name":"NICHE Research Group, Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Daowd","sequence":"additional","affiliation":[{"name":"NICHE Research Group, Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samina","family":"Abidi","sequence":"additional","affiliation":[{"name":"NICHE Research Group, Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada"},{"name":"Department of Community Health and Epidemiology, Faculty of Medicine, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","MEDINFO 2021: One World, One Health \u2013 Global Partnership for Digital Innovation"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI220084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T09:31:29Z","timestamp":1654594289000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI220084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti220084","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,6]]}}}