{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T10:15:49Z","timestamp":1654596949590},"reference-count":0,"publisher":"IOS Press","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,6]]},"abstract":"<jats:p>Spinocerebellar ataxia type 12 (SCA12) is a neurodegenerative genetic disorder triggered by abnormal CAG repeat expansion at locus 5q32. MRI recognises dissimilarities in affected areas of SCA12 patients and healthy subjects. But manual diagnosis is time-consuming and prone to subjective errors. This has motivated us in developing a systematic and authentic decision model for computer-aided diagnosis (CAD) of SCA12. Four different feature extraction techniques are examined in this research work, such as First Order Statistics, GLRLM, GLCM, and GLGCM, to obtain distinguishable characteristics for differentiating SCA12 patients from healthy subjects. The model\u2019s performance is measured using sensitivity, specificity, accuracy and F1-score with leave-one-out cross-validation scheme. Our experimental results show that features based on the GLRLM can distinguish SCA12 from healthy subjects with a maximum classification accuracy of 85% among all the different function extraction techniques used.<\/jats:p>","DOI":"10.3233\/shti220162","type":"book-chapter","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T09:33:18Z","timestamp":1654594398000},"source":"Crossref","is-referenced-by-count":0,"title":["Study of 2D Feature Extraction Techniques for Classification of Spinocerebellar Ataxia Type 12 (SCA12)"],"prefix":"10.3233","author":[{"given":"Snigdha","family":"Agrawal","sequence":"first","affiliation":[{"name":"School of Computer and Systems Sciences, Jawaharlal Nehru University, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senthil S.","family":"Kumaran","sequence":"additional","affiliation":[{"name":"Department of MRI and NMR, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achal Kumar","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh Kumar","family":"Agrawal","sequence":"additional","affiliation":[{"name":"School of Computer and Systems Sciences, Jawaharlal Nehru University, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manpreet Kaur","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","MEDINFO 2021: One World, One Health \u2013 Global Partnership for Digital Innovation"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI220162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T09:33:19Z","timestamp":1654594399000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI220162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti220162","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,6]]}}}