{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T23:13:30Z","timestamp":1776035610241,"version":"3.50.1"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643682846","type":"print"},{"value":"9781643682853","type":"electronic"}],"license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,25]]},"abstract":"<jats:p>Sharing observational and interventional health data within a common data space enables university hospitals to leverage such data for biomedical discovery and moving towards a learning health system. Objective: To describe the AP-HP Health Data Space (AHDS) and the IT services supporting piloting, research, innovation and patient care. Methods: Built on three pillars \u2013 governance and ethics, technology and valorization \u2013 the AHDS and its major component, the Clinical Data Warehouse (CDW) have been developed since 2015. Results: The AP-HP CDW has been made available at scale to AP-HP both healthcare professionals and public or private partners in January 2017. Supported by an institutional secured and high-performance cloud and an ecosystem of tools, mostly open source, the AHDS integrates a large amount of massive healthcare data collected during care and research activities. As of December 2021, the AHDS operates the electronic data capture for almost +840 clinical trials sponsored by AP-HP, the CDW is enabling the processing of health data from more than 11 million patients and generated +200 secondary data marts from IRB authorized research projects. During the Covid-19 pandemic, AHDS has had to evolve quickly to support administrative professionals and caregivers heavily involved in the reorganization of both patient care and biomedical research. Conclusion: The AP-HP Data Space is a key facilitator for data-driven evidence generation and making the health system more efficient and personalized.<\/jats:p>","DOI":"10.3233\/shti220390","type":"book-chapter","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T12:12:33Z","timestamp":1653480753000},"source":"Crossref","is-referenced-by-count":6,"title":["AP-HP Health Data Space (AHDS) to the Test of the Covid-19 Pandemic"],"prefix":"10.3233","author":[{"given":"Christel","family":"Daniel","sequence":"first","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"},{"name":"LIMICS, F-75006, Paris, France"},{"name":"Sorbonne Universit\u00e9s, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"AP-HP Covid CDW Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Paris","sequence":"additional","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Pierre","sequence":"additional","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Griffon","sequence":"additional","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"},{"name":"LIMICS, F-75006, Paris, France"},{"name":"Sorbonne Universit\u00e9s, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Breant","sequence":"additional","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Orlova","sequence":"additional","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Serre","sequence":"additional","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Leprovost","sequence":"additional","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"},{"name":"LIMICS, F-75006, Paris, France"},{"name":"Sorbonne Universit\u00e9s, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Denglos","sequence":"additional","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Mouchet","sequence":"additional","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Dubiel","sequence":"additional","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Gozlan","sequence":"additional","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Chatellier","sequence":"additional","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Bey","sequence":"additional","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Medical Information (DIM), H\u00f4pitaux Universitaires Paris-Saclay, AP-HP Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Hassen-Khodja","sequence":"additional","affiliation":[{"name":"Direction de la Recherche Clinique et de l\u2019Innovation, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-France","family":"Mamzer","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hilka","sequence":"additional","affiliation":[{"name":"Innovation and Data, IT Department, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Challenges of Trustable AI and Added-Value on 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