{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T12:41:59Z","timestamp":1653482519138},"reference-count":0,"publisher":"IOS Press","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,25]]},"abstract":"<jats:p>The frequency of potential drug-drug interactions (DDI) in published studies on real world data considerably varies due to the methodological framework. Contextualization of DDI has a proven effect in limiting false positives. In this paper, we experimented with the application of various DDIs contexts elements to see their impact on the frequency of potential DDIs measured on the same set of prescription data collected in EDSaN, the clinical data warehouse of Rouen University Hospital. Depending on the context applied, the frequency of daily prescriptions with potential DDI ranged from 0.89% to 3.90%. Substance-level analysis accounted for 48% of false positives because it did not account for some drug-related attributes. Consideration of the patient\u2019s context could eliminate up to an additional 29% of false positives.<\/jats:p>","DOI":"10.3233\/shti220392","type":"book-chapter","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T12:12:34Z","timestamp":1653480754000},"source":"Crossref","is-referenced-by-count":0,"title":["When Context Matters for Credible Measurement of Drug-Drug Interactions Based on Real-World Data"],"prefix":"10.3233","author":[{"given":"Romain","family":"Lelong","sequence":"first","affiliation":[{"name":"Universit\u00e9 Sorbonne Paris Nord, Laboratoire d\u2019Informatique M\u00e9dicale et d\u2019Ing\u00e9nierie des connaissances en e-Sant\u00e9, LIMICS, SorbonneUniversit\u00e9, INSERM, F-93000, Bobigny, France"},{"name":"Department of Digital Health, Rouen University Hospital, Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badisse","family":"Dahamna","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Sorbonne Paris Nord, Laboratoire d\u2019Informatique M\u00e9dicale et d\u2019Ing\u00e9nierie des connaissances en e-Sant\u00e9, LIMICS, SorbonneUniversit\u00e9, INSERM, F-93000, Bobigny, France"},{"name":"Department of Digital Health, Rouen University Hospital, Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Berthelot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Sorbonne Paris Nord, Laboratoire d\u2019Informatique M\u00e9dicale et d\u2019Ing\u00e9nierie des connaissances en e-Sant\u00e9, LIMICS, SorbonneUniversit\u00e9, INSERM, F-93000, Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willy","family":"Duville","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Sorbonne Paris Nord, Laboratoire d\u2019Informatique M\u00e9dicale et d\u2019Ing\u00e9nierie des connaissances en e-Sant\u00e9, LIMICS, SorbonneUniversit\u00e9, INSERM, F-93000, Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Letord","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Sorbonne Paris Nord, Laboratoire d\u2019Informatique M\u00e9dicale et d\u2019Ing\u00e9nierie des connaissances en e-Sant\u00e9, LIMICS, SorbonneUniversit\u00e9, INSERM, F-93000, Bobigny, France"},{"name":"Department of Digital Health, Rouen University Hospital, Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Grosjean","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Sorbonne Paris Nord, Laboratoire d\u2019Informatique M\u00e9dicale et d\u2019Ing\u00e9nierie des connaissances en e-Sant\u00e9, LIMICS, SorbonneUniversit\u00e9, INSERM, F-93000, Bobigny, France"},{"name":"Department of Digital Health, Rouen University Hospital, Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Duclos","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Sorbonne Paris Nord, Laboratoire d\u2019Informatique M\u00e9dicale et d\u2019Ing\u00e9nierie des connaissances en e-Sant\u00e9, LIMICS, SorbonneUniversit\u00e9, INSERM, F-93000, Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Challenges of Trustable AI and Added-Value on Health"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI220392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T12:12:35Z","timestamp":1653480755000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI220392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti220392","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,25]]}}}