{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T12:43:04Z","timestamp":1653482584727},"reference-count":0,"publisher":"IOS Press","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,25]]},"abstract":"<jats:p>Gene expression profiles can capture significant molecular differences paving the way toward precision medicine. However, clinical standards like FHIR only provide encoding of molecular sequence variations, even so, expression patterns are equally important for decision making. Here we provide an exemplary implementation of gene expression profiles of a microarray analysis using an adaption of the FHIR Genomics extension. Our results demonstrate how FHIR resources can be facilitated in bioinformatics-based decision support systems or used for the aggregation of molecular genetics data in multi-center clinical trials.<\/jats:p>","DOI":"10.3233\/shti220490","type":"book-chapter","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T12:14:29Z","timestamp":1653480869000},"source":"Crossref","is-referenced-by-count":0,"title":["Implementation of Gene Expression Profiles in the HL7 FHIR Standard"],"prefix":"10.3233","author":[{"given":"Florian","family":"Auer","sequence":"first","affiliation":[{"name":"IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany"}]},{"given":"Zhibek","family":"Abdykalykova","sequence":"additional","affiliation":[{"name":"IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany"}]},{"given":"Dominik","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany"}]},{"given":"Frank","family":"Kramer","sequence":"additional","affiliation":[{"name":"IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Challenges of Trustable AI and Added-Value on Health"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI220490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T12:14:35Z","timestamp":1653480875000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI220490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti220490","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,25]]}}}