{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:24:29Z","timestamp":1776871469037,"version":"3.51.2"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643682846","type":"print"},{"value":"9781643682853","type":"electronic"}],"license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,25]]},"abstract":"<jats:p>The pharmaceutical industry is a data-intensive environment and a heavily-regulated sector, where exhaustive audits and inspections are performed to ensure the safety of drugs. In this context, processing and evaluating the data generated in the manufacturing lines is a relevant challenge since it requires compliance with pharma regulations. This work combines data integrity metrics and blockchain technology to evaluate the compliance-degree of ALCOA+ principles among different levels of drug manufacturing data. We propose the DIALCOA tool, a software to assess the compliance-degree for each ALCOA+ principle, based on the assessment of data from manufacturing batch reports and its different levels of information.<\/jats:p>","DOI":"10.3233\/shti220578","type":"book-chapter","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T12:17:19Z","timestamp":1653481039000},"source":"Crossref","is-referenced-by-count":2,"title":["Towards a Computational Approach for the Assessment of Compliance of ALCOA+ Principles in Pharma Industry"],"prefix":"10.3233","author":[{"given":"Marta","family":"Dur\u00e1","sequence":"first","affiliation":[{"name":"Biomedical Data Science Lab, Instituto Universitario de Tecnolog\u00edas de la Informaci\u00f3n y Comunicaciones, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Ver s\/n, Valencia 46022, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel","family":"S\u00e1nchez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Biomedical Data Science Lab, Instituto Universitario de Tecnolog\u00edas de la Informaci\u00f3n y Comunicaciones, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Ver s\/n, Valencia 46022, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"S\u00e1ez","sequence":"additional","affiliation":[{"name":"Biomedical Data Science Lab, Instituto Universitario de Tecnolog\u00edas de la Informaci\u00f3n y Comunicaciones, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Ver s\/n, Valencia 46022, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1tima","family":"Leal","sequence":"additional","affiliation":[{"name":"REMIT, Universidade Portucalense, R. Dr. Ant\u00f3nio Bernardino de Almeida 541, 4200-072 Porto, Portugal"},{"name":"Cloud Competency Centre, School of Computing, National College of Ireland, Mayor Street, IFSC, Dublin D01 K6W2, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana E.","family":"Chis","sequence":"additional","affiliation":[{"name":"Cloud Competency Centre, School of Computing, National College of Ireland, Mayor Street, IFSC, Dublin D01 K6W2, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horacio","family":"Gonz\u00e1lez-V\u00e9lez","sequence":"additional","affiliation":[{"name":"Cloud Competency Centre, School of Computing, National College of Ireland, Mayor Street, IFSC, Dublin D01 K6W2, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan M.","family":"Garc\u00eda-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Biomedical Data Science Lab, Instituto Universitario de Tecnolog\u00edas de la Informaci\u00f3n y Comunicaciones, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Ver s\/n, Valencia 46022, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Challenges of Trustable AI and Added-Value on Health"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI220578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T12:17:20Z","timestamp":1653481040000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI220578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,25]]},"ISBN":["9781643682846","9781643682853"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti220578","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,25]]}}}