{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T08:13:10Z","timestamp":1656576790081},"reference-count":0,"publisher":"IOS Press","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,29]]},"abstract":"<jats:p>High-throughput technologies, especially gene expression analyses can accurately capture the molecular state in patients under different conditions. Thus, their application in clinical routine gains increasing relevance and fosters patient stratification towards individualized treatment decisions. Electronic health records already evolved to capture genomic data within clinical systems and standards like FHIR enable sharing within, and even between institutions. However, FHIR only provides profiles tailored to variations in the molecular sequence, while expression patterns are neglected although being equally important for decision making. Here we provide an exemplary implementation of gene expression profiles of a microarray analysis of patients with acute myeloid leukemia using an adaptation of the FHIR genomics extension. Our results demonstrate how FHIR resources can be facilitated in clinical systems and thereby pave the way for usage for the aggregation and exchange of transcriptomic data in multi-center studies.<\/jats:p>","DOI":"10.3233\/shti220730","type":"book-chapter","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T07:33:53Z","timestamp":1656574433000},"source":"Crossref","is-referenced-by-count":0,"title":["Adaptation of HL7 FHIR for the Exchange of Patients\u2019 Gene Expression Profiles"],"prefix":"10.3233","author":[{"given":"Florian","family":"Auer","sequence":"first","affiliation":[{"name":"IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany"}]},{"given":"Zhibek","family":"Abdykalykova","sequence":"additional","affiliation":[{"name":"IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany"}]},{"given":"Dominik","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany"}]},{"given":"Frank","family":"Kramer","sequence":"additional","affiliation":[{"name":"IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Advances in Informatics, Management and Technology in Healthcare"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI220730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T07:33:53Z","timestamp":1656574433000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI220730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti220730","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,29]]}}}