{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:14:46Z","timestamp":1706228086639},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643684567","type":"print"},{"value":"9781643684574","type":"electronic"}],"license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,25]]},"abstract":"<jats:p>Frailty is associated with a higher risk of death among kidney transplant candidates. Currently available frailty indices are often based on clinical impression, physical exam or an accumulation of deficits across domains of health. In this paper we investigate a clustering based approach that partitions the data based on similarities between individuals to generate phenotypes of kidney transplant candidates. We analyzed a multicenter cohort that included several features typically used to determine an individual\u2019s level of frailty. We present a clustering based phenotyping approach, where we investigated two clustering approaches\u2014i.e. neural network based Self-Organizing Maps (SOM) with hierarchical clustering, and KAMILA (KAy-means for MIxed LArge data sets). Our clustering results partition the individuals across 3 distinct clusters. Clusters were used to generate and study feature-level phenotypes of each group.<\/jats:p>","DOI":"10.3233\/shti231094","type":"book-chapter","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T10:25:34Z","timestamp":1706178334000},"source":"Crossref","is-referenced-by-count":0,"title":["Characterizing Cluster-Based Frailty Phenotypes in a Multicenter Prospective Cohort of Kidney Transplant Candidates"],"prefix":"10.3233","author":[{"given":"Syed Hani Raza","family":"Abidi","sequence":"first","affiliation":[{"name":"Faculty of Computer Science, Dalhousie University, Halifax, NS, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur","family":"Zincir-Heywood","sequence":"additional","affiliation":[{"name":"Faculty of Computer Science, Dalhousie University, Halifax, NS, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Sibte Raza","family":"Abidi","sequence":"additional","affiliation":[{"name":"Faculty of Computer Science, Dalhousie University, Halifax, NS, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kranthi","family":"Jalakam","sequence":"additional","affiliation":[{"name":"Faculty of Computer Science, Dalhousie University, Halifax, NS, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samina","family":"Abidi","sequence":"additional","affiliation":[{"name":"Dept. of Community Health & Epidemiology, Dalhousie University, Halifax, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshman","family":"Gunaratnam","sequence":"additional","affiliation":[{"name":"Division of Nephrology, London Health Sciences Center, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Suri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lo\u00efse","family":"Cardinale","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Centre de Recherche du CHUM, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Vinson","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Dept. of Medicine, Dalhousie University, Halifax, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhanu","family":"Prasad","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Regina General Hospital, Regina, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Walsh","sequence":"additional","affiliation":[{"name":"Division of Nephrology, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seychelle","family":"Yohanna","sequence":"additional","affiliation":[{"name":"Division of Nephrology, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Worthen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Dept. of Medicine, Dalhousie University, Halifax, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthik","family":"Tennankore","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Dept. of Medicine, Dalhousie University, Halifax, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","MEDINFO 2023 \u2014 The Future Is Accessible"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI231094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T10:25:36Z","timestamp":1706178336000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI231094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"ISBN":["9781643684567","9781643684574"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti231094","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,25]]}}}