{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:26:32Z","timestamp":1778603192055,"version":"3.51.4"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643684567","type":"print"},{"value":"9781643684574","type":"electronic"}],"license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,25]]},"abstract":"<jats:p>Previous studies demonstrated an association between influenza vaccination and the likelihood of developing Alzheimer\u2019s disease. This study was aimed at assessing whether pneumococcal vaccinations are associated with a lower risk of Alzheimer\u2019s disease based on analysis of data from the IBM\u00ae MarketScan\u00ae Database. Vaccinated and unvaccinated matched cohorts were generated using propensity-score matching with the greedy nearest-neighbor matching algorithm. The conditional logistic regression method was used to estimate the relationship between pneumococcal vaccination and the onset of Alzheimer\u2019s disease. There were 142,874 subjects who received the pneumococcal vaccine and 14,392 subjects who did not. The conditional logistic regression indicated that the people who received the pneumococcal vaccine had a significantly lower risk of developing Alzheimer\u2019s disease as compared to the people who did not receive any pneumococcal vaccine (OR=0.37; 95%CI: 0.33-0.42; P-value &lt; .0001). Our findings demonstrated that the pneumococcal vaccine was associated with a 63% reduction in the risk of Alzheimer\u2019s disease among US adults aged 65 and older.<\/jats:p>","DOI":"10.3233\/shti231107","type":"book-chapter","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T10:26:05Z","timestamp":1706178365000},"source":"Crossref","is-referenced-by-count":4,"title":["Pneumococcal Vaccination Lowers the Risk of Alzheimer\u2019s Disease: A Study Utilizing Data from the IBM\u00ae MarketScan\u00ae Database"],"prefix":"10.3233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5135-0292","authenticated-orcid":false,"given":"Xingyue","family":"Huo","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Finkelstein","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","MEDINFO 2023 \u2014 The Future Is Accessible"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI231107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T10:26:07Z","timestamp":1706178367000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI231107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"ISBN":["9781643684567","9781643684574"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti231107","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,25]]}}}