{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:12:50Z","timestamp":1706227970708},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643684567","type":"print"},{"value":"9781643684574","type":"electronic"}],"license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,25]]},"abstract":"<jats:p>We introduce a phenotyping pipeline for voriconazole hepatotoxicity based on a multi-center clinical research platform. Using the platform\u2019s queue construction, feature generation, and feature screening functions, 52 features were obtained for model training. The prediction model of voriconazole hepatotoxicity was obtained by using the model training and evaluation functions of the platform. Important risk factors and protection factors of the model were listed.<\/jats:p>","DOI":"10.3233\/shti231255","type":"book-chapter","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T10:30:46Z","timestamp":1706178646000},"source":"Crossref","is-referenced-by-count":0,"title":["Design and Application of Multi-Center Clinical Research Platform for Phenotyping of Voriconazole Hepatotoxicity"],"prefix":"10.3233","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Research Center for Healthcare Data Science, Zhejiang Lab, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Healthcare Data Science, Zhejiang Lab, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengqiang","family":"Chi","sequence":"additional","affiliation":[{"name":"Research Center for Healthcare Data Science, Zhejiang Lab, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Ru","sequence":"additional","affiliation":[{"name":"Research Center for Healthcare Data Science, Zhejiang Lab, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Research Center for Healthcare Data Science, Zhejiang Lab, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[{"name":"Engineering Research Center of EMR and Intelligent Expert System, Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianshu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Research Center for Healthcare Data Science, Zhejiang Lab, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingsong","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center for Healthcare Data Science, Zhejiang Lab, Hangzhou, China"},{"name":"Engineering Research Center of EMR and Intelligent Expert System, Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","MEDINFO 2023 \u2014 The Future Is Accessible"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI231255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T10:30:47Z","timestamp":1706178647000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI231255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"ISBN":["9781643684567","9781643684574"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti231255","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,25]]}}}