{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T04:04:24Z","timestamp":1747454664586,"version":"3.40.5"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643685960","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:p>This study presents the development of a customizable rule-based engine, integrated into the LETHE Clinical Trial Management System (CTMS), designed to enhance clinical decision-making in a multidomain intervention for dementia risk reduction. The rule engine allows health professionals to create and personalize rules based on patient-specific profiles and evolving clinical knowledge, enabling more precise interventions. The system was developed through a collaborative approach with one health professional and employs a JSON based rules engine for flexible rule creation and implementation. Its application in the LETHE project, a randomized control trial involving 156 participants across multiple centers, demonstrates the potential of tailored digital interventions in improving clinical outcomes. Future enhancements will focus on broadening the system\u2019s usability and automating patient-specific tasks to streamline care.<\/jats:p>","DOI":"10.3233\/shti250276","type":"book-chapter","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T08:52:44Z","timestamp":1747385564000},"source":"Crossref","is-referenced-by-count":0,"title":["Customizable Rule-Based System for Enhanced Clinical Decision-Making in Dementia Risk Reduction"],"prefix":"10.3233","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9198-7177","authenticated-orcid":false,"given":"Laura","family":"Pluch","sequence":"first","affiliation":[{"name":"Institute of eHealth, University of Applied Sciences - FH JOANNEUM, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3867-0651","authenticated-orcid":false,"given":"Hannes","family":"Hilberger","sequence":"additional","affiliation":[{"name":"Institute of eHealth, University of Applied Sciences - FH JOANNEUM, Graz, Austria"},{"name":"GSRC, Division of Medical Physics and Biophysics, Medical University of Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6018-7821","authenticated-orcid":false,"given":"Markus","family":"B\u00f6denler","sequence":"additional","affiliation":[{"name":"Institute of eHealth, University of Applied Sciences - FH JOANNEUM, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5015-4718","authenticated-orcid":false,"given":"Helena","family":"Untersteiner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Vienna, Vienna, Austria"},{"name":"Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3833-4252","authenticated-orcid":false,"given":"Sten","family":"Hanke","sequence":"additional","affiliation":[{"name":"Institute of eHealth, University of Applied Sciences - FH JOANNEUM, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Intelligent Health Systems \u2013 From Technology to Data and Knowledge"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI250276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T08:52:44Z","timestamp":1747385564000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI250276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"ISBN":["9781643685960"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti250276","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]}}}