{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:02:43Z","timestamp":1778518963191,"version":"3.51.4"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643685960","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:p>The evaluation of clinical decision support systems (CDSS) during randomized clinical trials in very long and complex to set up. Simulation trials consist of evaluating the CDSS on fictitious patients. While they cannot entirely replace clinical trials, they are simpler to perform and offer additional possibilities. In this paper, we present recommendations for the design of simulation trials evaluating CDSS, based on the lessons learned during two recent studies. We also propose a model of protocol that maximizes statistical power and avoids several common biases, and an R code template for statistical analysis using linear mixed models.<\/jats:p>","DOI":"10.3233\/shti250304","type":"book-chapter","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T08:53:17Z","timestamp":1747385597000},"source":"Crossref","is-referenced-by-count":2,"title":["Simulation Trials for Evaluating Clinical Decision Support Systems"],"prefix":"10.3233","author":[{"given":"Jean-Baptiste","family":"Lamy","sequence":"first","affiliation":[{"name":"INSERM, Universit\u00e9 Sorbonne Paris Nord, Sorbonne Universit\u00e9, LIMICS, Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector","family":"Falcoff","sequence":"additional","affiliation":[{"name":"SFTG Recherche (Soci\u00e9t\u00e9 de Formation Th\u00e9rapeutique du G\u00e9n\u00e9raliste), Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Dubois","sequence":"additional","affiliation":[{"name":"SFTG Recherche (Soci\u00e9t\u00e9 de Formation Th\u00e9rapeutique du G\u00e9n\u00e9raliste), Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Meneton","sequence":"additional","affiliation":[{"name":"INSERM, Universit\u00e9 Sorbonne Paris Nord, Sorbonne Universit\u00e9, LIMICS, Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosy","family":"Tsopra","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Inserm, CRC, F-75006 Paris"},{"name":"Dpt. of Medical Informatics, AP-HP, H\u00f4pital Europ\u00e9en Georges-Pompidou Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Saab","sequence":"additional","affiliation":[{"name":"INSERM, Universit\u00e9 Sorbonne Paris Nord, Sorbonne Universit\u00e9, LIMICS, Paris France"},{"name":"Quality and Patient Safety Dpt., Lebanese Hospital Geitaoui-UMC, Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Intelligent Health Systems \u2013 From Technology to Data and Knowledge"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI250304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T08:53:17Z","timestamp":1747385597000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI250304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"ISBN":["9781643685960"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti250304","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]}}}