{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T09:46:28Z","timestamp":1772531188990,"version":"3.50.1"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643685960","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:p>Background: Patient similarity analysis is pivotal in cancer research and clinical oncology, aiding in identifying patterns among patients with similar clinical and molecular profiles to guide therapeutic decisions, particularly in Molecular Tumor Boards (MTB), where therapy decisions are frequently informed by the treatment experiences of previously treated similar patients. However, the lack of standardized tools for automation and visualization limits efficiency here, especially in individualized MTB decisions. Objective: This study aims to develop a graphical user interface that aligns with clinician preferences to enhance patient similarity assessments and support decision-making in MTBs. Methods: Visualization concepts were developed through iterative design and evaluation cycles involving clinical experts. Mock-ups were created to represent various approaches for displaying patient similarities, focusing on molecular data relevant to MTB decisions. Results: Various designs were developed for visualizing patient similarity in cBioPortal. These include tabular views, network representations, and radar plots. Conclusions: These visualizations offer promise in enhancing decision-making in MTBs by making patient similarity assessments more accessible. Future development will focus on additional functionalities and better integration into clinical workflows.<\/jats:p>","DOI":"10.3233\/shti250385","type":"book-chapter","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T08:55:17Z","timestamp":1747385717000},"source":"Crossref","is-referenced-by-count":3,"title":["Prototypical Visualization of Patient Similarities in cBioPortal to Enhance Decision-Making in Molecular Tumor Boards"],"prefix":"10.3233","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7946-8559","authenticated-orcid":false,"given":"Jan","family":"Bossenz","sequence":"first","affiliation":[{"name":"Junior Research Group (Bio-)Medical Data Science, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8821-1471","authenticated-orcid":false,"given":"Iryna","family":"Manuilova","sequence":"additional","affiliation":[{"name":"Junior Research Group (Bio-)Medical Data Science, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6925-5941","authenticated-orcid":false,"given":"Annemarie Bianka","family":"Weise","sequence":"additional","affiliation":[{"name":"Junior Research Group (Bio-)Medical Data Science, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3856-7956","authenticated-orcid":false,"given":"Susann","family":"Schulze","sequence":"additional","affiliation":[{"name":"Krukenberg Cancer Center Halle (Saale), Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2886-9485","authenticated-orcid":false,"given":"Sonja","family":"Hiemer","sequence":"additional","affiliation":[{"name":"Krukenberg Cancer Center Halle (Saale), Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4732-2934","authenticated-orcid":false,"given":"Markus","family":"Eszlinger","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Hospital Halle, Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3670-0602","authenticated-orcid":false,"given":"Melanie","family":"Boerries","sequence":"additional","affiliation":[{"name":"Institute of Medical Bioinformatics and Systems Medicine (IBSM), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4763-4521","authenticated-orcid":false,"given":"Hauke","family":"Busch","sequence":"additional","affiliation":[{"name":"Medical Systems Biology Group, L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck, L\u00fcbeck, Germany"},{"name":"University Cancer Center Schleswig-Holstein, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2887-7109","authenticated-orcid":false,"given":"Dominik","family":"Boehm","sequence":"additional","affiliation":[{"name":"Medical Center for Information and Communication Technology, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"},{"name":"Bavarian Cancer Research Center (Bayerisches Zentrum f\u00fcr Krebsforschung)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1269-9360","authenticated-orcid":false,"given":"Philipp","family":"Unberath","sequence":"additional","affiliation":[{"name":"Medical Center for Information and Communication Technology, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"},{"name":"SRH F\u00fcrth University of Applied Sciences, F\u00fcrth, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0491-3929","authenticated-orcid":false,"given":"Niklas","family":"Reimer","sequence":"additional","affiliation":[{"name":"Medical Systems Biology Group, L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck, L\u00fcbeck, Germany"},{"name":"Medical Data Integration Center, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3980-8233","authenticated-orcid":false,"given":"Cosima","family":"Strantz","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Medical Informatics, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4369-3591","authenticated-orcid":false,"given":"Jan","family":"Christoph","sequence":"additional","affiliation":[{"name":"Junior Research Group (Bio-)Medical Data Science, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany"},{"name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Medical Informatics, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Intelligent Health Systems \u2013 From Technology to Data and Knowledge"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI250385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T08:55:17Z","timestamp":1747385717000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI250385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"ISBN":["9781643685960"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti250385","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]}}}