{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:36:24Z","timestamp":1768448184534,"version":"3.49.0"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643685960","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:p>The utilisation of routine clinical data is increasingly vital for analysing care quality and supporting clinical decisions. This study within the POLAR_MI consortium developed a FHIR-based distributed validation method to quantify amitriptyline prescriptions in patients aged \u226565 years. Data from 10 German university hospitals were aggregated and validated through bidirectional checks, achieving 100% accuracy for inpatient and 82.7% for outpatient amitriptyline identification. High inter-rater reliability (Krippendorff\u2019s Alpha = 0.9814) confirmed data validity. Our approach demonstrated the feasibility of using standardised FHIR specifications for robust, privacy-compliant evidence generation in large-scale pharmacovigilance studies.<\/jats:p>","DOI":"10.3233\/shti250573","type":"book-chapter","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T09:00:50Z","timestamp":1747386050000},"source":"Crossref","is-referenced-by-count":1,"title":["Reliability of Multicentric Extracted EMR Data: Quantifying Amitriptyline Use in Elderly Patients \u2013 A POLAR_MI Study"],"prefix":"10.3233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4639-5189","authenticated-orcid":false,"given":"Daniel","family":"Neumann","sequence":"first","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology, University Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"POLAR_MI Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Kesselmeier","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics, Computer and Data Sciences (IMSID), Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louisa","family":"Redeker","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, School of Medicine, Faculty of Health, Witten\/Herdecke University, Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology, University Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Thalheim","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre for Bioinformatics, University Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Peschel","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology, University Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Haerterich","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Meineke","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology, University Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Schmiedl","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, School of Medicine, Faculty of Health, Witten\/Herdecke University, Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra A.","family":"Thuermann","sequence":"additional","affiliation":[{"name":"Helios University Hospital Wuppertal, Chair of Clinical Pharmacology, University Witten\/Herdecke, Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Scherag","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics, Computer and Data Sciences (IMSID), Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology, University Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Intelligent Health Systems \u2013 From Technology to Data and Knowledge"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI250573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T09:00:50Z","timestamp":1747386050000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI250573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"ISBN":["9781643685960"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti250573","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]}}}