{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:40:34Z","timestamp":1784220034967,"version":"3.55.0"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643685960","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:p>Pharmacist interventions significantly reduce medication errors and improve drug-therapy safety, with IT-supported workflows, including Clinical Decision Support Systems (CDSS), enhancing real-time decision-making. To address challenges in Germany\u2019s federated hospital system, the INTERPOLAR study platform integrates real-world data into routine care workflows. Developed under the Medical Informatics Initiative (MII), the platform leverages a CDS Toolchain with FHIR-based data items, predefined triggers, real-time feedback, and a robust data security framework. The platform supports diverse study designs, aligning technical capabilities with clinical workflows through process mapping and requirements engineering. A centralized health data warehouse enables large-scale analysis while ensuring GDPR compliance. Initial results demonstrate harmonized documentation, improved detection of drug-related problems (DRPs), and efficiency gains via automation. Current studies include medication adherence, ADEs, and pharmacist intervention impacts. By embedding IT-supported workflows into routine care, INTERPOLAR provides a scalable, federated solution for drug-therapy safety research, contributing to global pharmacovigilance and advancing evidence-based medicine.<\/jats:p>","DOI":"10.3233\/shti250599","type":"book-chapter","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T09:01:31Z","timestamp":1747386091000},"source":"Crossref","is-referenced-by-count":1,"title":["INTERPOLAR_MI \u2013 A Study Platform Concept for IT-Supported Drug Therapy Safety Research"],"prefix":"10.3233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4639-5189","authenticated-orcid":false,"given":"Daniel","family":"Neumann","sequence":"first","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology; University Leipzig; Leipzig; Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"INTERPOLAR Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Staeubert","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology; University Leipzig; Leipzig; Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Struebing","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology; University Leipzig; Leipzig; Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology; University Leipzig; Leipzig; Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Reusche","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology; University Leipzig; Leipzig; Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Beppler","sequence":"additional","affiliation":[{"name":"Institute for Medical Statistics, Computer and Data Sciences (IMSID); University Hospital Jena; Jena; Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Meineke","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology; University Leipzig; Leipzig; Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Scherag","sequence":"additional","affiliation":[{"name":"Institute for Medical Statistics, Computer and Data Sciences (IMSID); University Hospital Jena; Jena; Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology; University Leipzig; Leipzig; Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Intelligent Health Systems \u2013 From Technology to Data and Knowledge"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI250599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T09:01:32Z","timestamp":1747386092000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI250599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"ISBN":["9781643685960"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti250599","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]}}}