{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:45:56Z","timestamp":1777553156679,"version":"3.51.4"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643686080","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,7]]},"abstract":"<jats:p>Colorectal cancer (CRC), the second deadliest cancer globally, is closely tied to gut microbiota, opening doors for early detection and treatment. This review of 45 studies (2018\u20132024) highlights microbial biomarkers like Fusobacterium nucleatum, Bacteroides fragilis, and Parvimonas micra, with strong diagnostic accuracy (AUC &gt;80%) across populations. Techniques like 16S rRNA sequencing, metagenomics, and shotgun sequencing revealed these links. Gut-based diagnostics offer a non-invasive, cost-effective alternative to colonoscopy and FIT for spotting early CRC and precancerous lesions. Yet, regional microbial differences and inconsistent methods\u2014sample processing and sequencing\u2014hinder comparability. Standardizing approaches and exploring fungi and viruses are key to unlocking microbiota\u2019s full potential in CRC prevention, diagnosis, and therapy.<\/jats:p>","DOI":"10.3233\/shti251018","type":"book-chapter","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T11:38:15Z","timestamp":1754566695000},"source":"Crossref","is-referenced-by-count":1,"title":["Unraveling the Role of Gut Microbiota in Colorectal Cancer: A Global Perspectives and Biomarkers as Early Screening Tool for Colorectal Cancer"],"prefix":"10.3233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2581-8007","authenticated-orcid":false,"given":"Umashankar","family":"Upadhyay","sequence":"first","affiliation":[{"name":"Graduate Institute of Biomedical Informatics, College of Medical Sciences and Technology, Taipei Medical University, Taipei, Taiwan"},{"name":"International Center for Health Information Technology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan"},{"name":"Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, India"}]},{"given":"Eshita","family":"Dhar","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Informatics, College of Medical Sciences and Technology, Taipei Medical University, Taipei, Taiwan"},{"name":"International Center for Health Information Technology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan"}]},{"given":"Sherali","family":"Bomrah","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Informatics, College of Medical Sciences and Technology, Taipei Medical University, Taipei, Taiwan"},{"name":"International Center for Health Information Technology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0412-767X","authenticated-orcid":false,"given":"Shabbir","family":"Syed-Abdul","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Informatics, College of Medical Sciences and Technology, Taipei Medical University, Taipei, Taiwan"},{"name":"International Center for Health Information Technology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan"},{"name":"School of Gerontology and Long-term Care, College of Nursing, Taipei Medical University, Taipei, Taiwan"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","MEDINFO 2025 \u2014 Healthcare Smart \u00d7 Medicine Deep"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI251018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T11:38:16Z","timestamp":1754566696000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI251018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,7]]},"ISBN":["9781643686080"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti251018","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,7]]}}}