{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:03:47Z","timestamp":1755219827703,"version":"3.43.0"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643686080","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,7]]},"abstract":"<jats:p>Despite the great advancements in biomedical text mining, accurate extraction of phenotypical entities from unstructured texts is still a critical issue. This paper explores the extraction of phenotypical data from disease texts using ChatGPT 3.5 Turbo with various prompt engineering techniques. One hundred Wikipedia disease texts have been processed with multiple prompts to extract and structure phenotypical manifestations. The results compared with UMLS MetaMap, using metrics as precision, recall, and F1 score. Simpler prompts focused on extracting \u201cPhenotypical Manifestations\u201d performed best, achieving an F1 score of 0.60, though still below the MetaMap benchmark. In contrast, complex prompts using entity dictionaries or explanation steps led to lower precision and recall. Including the keyword \u201cmanifestations\u201d improved recall, while techniques like one-shot examples and prompt chaining had little effect. Overall, straightforward prompts were shown to be more effective in extracting phenotypical data entities.<\/jats:p>","DOI":"10.3233\/shti251225","type":"book-chapter","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T11:45:06Z","timestamp":1754567106000},"source":"Crossref","is-referenced-by-count":0,"title":["Using ChatGPT to Structure Phenotypical Entities from Disease Texts"],"prefix":"10.3233","author":[{"given":"Marcel Luis","family":"Palacios-Ja\u00e9n","sequence":"first","affiliation":[{"name":"Escuela T\u00e9cnica Superior de Ingenieros Inform\u00e1ticos, Universidad Polit\u00e9cnica de Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1545-3515","authenticated-orcid":false,"given":"Luc\u00eda","family":"Prieto-Santamar\u00eda","sequence":"additional","affiliation":[{"name":"Escuela T\u00e9cnica Superior de Ingenieros Inform\u00e1ticos, Universidad Polit\u00e9cnica de Madrid, Spain"},{"name":"Centro de Tecnolog\u00eda Biom\u00e9dica, Universidad Polit\u00e9cnica de Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5615-6798","authenticated-orcid":false,"given":"Ernestina","family":"Menasalvas","sequence":"additional","affiliation":[{"name":"Escuela T\u00e9cnica Superior de Ingenieros Inform\u00e1ticos, Universidad Polit\u00e9cnica de Madrid, Spain"},{"name":"Centro de Tecnolog\u00eda Biom\u00e9dica, Universidad Polit\u00e9cnica de Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8801-4762","authenticated-orcid":false,"given":"Alejandro","family":"Rodr\u00edguez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Escuela T\u00e9cnica Superior de Ingenieros Inform\u00e1ticos, Universidad Polit\u00e9cnica de Madrid, Spain"},{"name":"Centro de Tecnolog\u00eda Biom\u00e9dica, Universidad Polit\u00e9cnica de Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","MEDINFO 2025 \u2014 Healthcare Smart \u00d7 Medicine Deep"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI251225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T11:45:07Z","timestamp":1754567107000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI251225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,7]]},"ISBN":["9781643686080"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti251225","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,7]]}}}