{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:03:59Z","timestamp":1755219839893,"version":"3.43.0"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643686080","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,7]]},"abstract":"<jats:p>Patients with rheumatoid arthritis (RA) on biologic or targeted synthetic DMARDs (b\/ts DMARDs) face increased serious infection risk. This study developed and validated a machine learning model to predict one-year risk using data from Hong Kong\u2019s CDARS and the U.S. All of Us database. Among 3,159 CDARS and 1,845 All of Us patients, AUROCs were 0.840 and 0.729. Key predictors included prior infections, diabetes, DMARD type, and inflammatory markers. Rituximab posed the highest risk. The model supports personalized RA treatment and infection prevention.<\/jats:p>","DOI":"10.3233\/shti251271","type":"book-chapter","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T11:46:41Z","timestamp":1754567201000},"source":"Crossref","is-referenced-by-count":0,"title":["Predicting Infection Risk in Rheumatoid Arthritis Patients Treated with Biological and Targeted Synthetic Disease-Modifying Anti-Rheumatic Drugs: An Application of Machine Learning"],"prefix":"10.3233","author":[{"given":"Kuan","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"},{"name":"Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, 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Medicine, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff Jianfei","family":"Guo","sequence":"additional","affiliation":[{"name":"James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4836-7808","authenticated-orcid":false,"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"},{"name":"Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"},{"name":"Laboratory of Data Discovery for Health (D24H), Hong Kong Science Park, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","MEDINFO 2025 \u2014 Healthcare Smart \u00d7 Medicine Deep"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI251271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T11:46:42Z","timestamp":1754567202000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI251271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,7]]},"ISBN":["9781643686080"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti251271","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,7]]}}}