{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:37:53Z","timestamp":1779403073862,"version":"3.53.1"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643686615","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,21]]},"abstract":"<jats:p>Introduction: The \u2018triple whammy\u2019 (TW) interaction consists of three drug classes that enlarge the risk for an acute kidney injury (AKI). Inside the INTERPOLAR consortium a core data set (CDS) tool chain was developed to extract data from a clinical FHIR-server into a study database and enrich the data with Clinical Pharmacist (CP)-reported medication review data. Methods: Patients with TW-interactions were extracted from the local INTERPOLAR database for six standard care wards along with medication and serum creatinine data (SCr). The extracted TW data was checked for completeness and accuracy. Additionally, it was evaluated how this interaction was addressed by CP. Results: Twenty-one of 2,805 cases showed at least one correct TW-administration (prevalence 0.7%). Data was found to be correct for 95% of all TW-administration lines (364\/390 lines) and 97% of SCr values (73\/75 values). Most patients with TW-administrations were admitted to surgical wards (18\/21 patients). In 10\/21 cases CP recommended changing the medication. Only for 6\/21 TW patients enough SCr values were measured to calculate a potential adverse outcome (AKI). Discussion: Data could be extracted with sufficient precision to identify inpatient TW-interactions. Missing data mainly resulted from delayed resource arrival at the FHIR server. Limitations include the missing handling of intravenous medication compositions.<\/jats:p>","DOI":"10.3233\/shti260171","type":"book-chapter","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:57:11Z","timestamp":1779400631000},"source":"Crossref","is-referenced-by-count":0,"title":["Secondary Data for Clinical Pharmacists\u2019 Decision Support: Evaluating \u2018Triple Whammy\u2019 Interactions Within INTERPOLAR"],"prefix":"10.3233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-2102","authenticated-orcid":false,"given":"Joachim A.","family":"Koeck","sequence":"first","affiliation":[{"name":"Pharmacy Department, Universit\u00e4tsklinikum Erlangen and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"INTERPOLAR project of the German Medical Informatics Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"K\u00f6ster","sequence":"additional","affiliation":[{"name":"Medical Centre for Information and Communication Technology, Universit\u00e4tsklinikum Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology, Leipzig University, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Neumann","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology, Leipzig University, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ganslandt","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Institute for Medical Informatics, Biometrics and Epidemiology, Medical Informatics, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"D\u00f6rje","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Universit\u00e4tsklinikum Erlangen and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Opening the Personal Gate between Technology and Health Care"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI260171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:57:11Z","timestamp":1779400631000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI260171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"ISBN":["9781643686615"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti260171","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}