{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:37:04Z","timestamp":1779403024654,"version":"3.53.1"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643686615","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,21]]},"abstract":"<jats:p>Pancreatic cancer, characterised by high mortality and late diagnosis, urgently requires improved early detection methods. Unintentional weight loss, reported by 70\u201375% of patients prior to diagnosis, may serve as a key early marker. This systematic review and meta-analysis evaluated the extent of pre-diagnostic weight loss in pancreatic cancer patients compared with matched controls. Thirteen studies encompassing 12,081 cases and 367,678 controls were analysed, revealing a medium standardised mean difference (SMD = 0.51, [95% CI 0.31\u20130.71]) equivalent to a 2.26 kg\/m2 BMI reduction in people with pancreatic cancer. Significant heterogeneity was observed, influenced by country, publication year, cancer type and diabetes status. Weight loss may serve as a useful non-invasive biomarker for early pancreatic cancer detection, especially in those with new-onset diabetes. Using quantified weight loss data could enhance the accuracy of predictive algorithms, allowing their inclusion in EMR based detection pipelines, ultimately aiding earlier detection and improving survival outcomes.<\/jats:p>","DOI":"10.3233\/shti260172","type":"book-chapter","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:57:14Z","timestamp":1779400634000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparing Weight Loss Prior to Pancreatic Cancer Diagnosis in Cases and Controls: A Systematic Review and Meta-Analysis"],"prefix":"10.3233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3060-9821","authenticated-orcid":false,"given":"Claire A.","family":"Price","sequence":"first","affiliation":[{"name":"School of Health Sciences, University of Surrey, Guildford, UK"},{"name":"Data Science and AI Department, National Physical Laboratory, Teddington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freda","family":"Mold","sequence":"additional","affiliation":[{"name":"School of Health Sciences, University of Surrey, Guildford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"de Lusignan","sequence":"additional","affiliation":[{"name":"School of Health Sciences, University of Surrey, Guildford, UK"},{"name":"Nuffield Department of Primary Care Health Sciences, University of Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia A.S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Royal Surrey NHS Foundation Trust, Scientific Computing, Guildford, UK"},{"name":"T\u00dcV S\u00dcD UK, Chadwick House, Warrington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn","family":"Winn","sequence":"additional","affiliation":[{"name":"Science & Technology Facilities Council, Research Complex at Harwell, Didcot, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Lemanska","sequence":"additional","affiliation":[{"name":"Imperial Clinical Trials Unit, School of Public Health, Imperial College, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Opening the Personal Gate between Technology and Health Care"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI260172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:57:14Z","timestamp":1779400634000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI260172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"ISBN":["9781643686615"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti260172","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}