{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:44:46Z","timestamp":1779403486974,"version":"3.53.1"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643686615","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,21]]},"abstract":"<jats:p>Introduction: Semantic standardization is essential, but not sufficient, to enable research over real-world data networks. Even when harmonized, differences in data availability, granularity, and clinical practice can introduce subtle biases that affect downstream analyses and AI model development. Methods: This work explores laboratory data availability and testing practices using LOINC-coded data from TriNetX, a global federated research network. Significant LOINC part variations were identified using statistical dispersion assessment. Results: Data from 172 healthcare institutions was evaluated. Representative examples were further analysed demonstrating the relevance of specimen and method availability, as well as property and component country-specific differences. Conclusions: Acknowledging data variability is key to minimizing biases introduced during AI model development and research over clinical real-world data.<\/jats:p>","DOI":"10.3233\/shti260399","type":"book-chapter","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:03:53Z","timestamp":1779401033000},"source":"Crossref","is-referenced-by-count":0,"title":["Practical Implications for Using Laboratory Data: Research over Federated Networks"],"prefix":"10.3233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-8019","authenticated-orcid":false,"given":"David","family":"Rubio Ruiz","sequence":"first","affiliation":[{"name":"Biomedical Informatics Group, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain"},{"name":"TriNetX, LLC, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4504-9775","authenticated-orcid":false,"given":"A\u00edda","family":"Mu\u00f1oz Monjas","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Group, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain"},{"name":"TriNetX, LLC, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5253-5321","authenticated-orcid":false,"given":"Paula","family":"Bermejo Bernardo","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Group, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9021-2597","authenticated-orcid":false,"given":"David","family":"Perez-Rey","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Group, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7737-8752","authenticated-orcid":false,"given":"Matvey B.","family":"Palchuk","sequence":"additional","affiliation":[{"name":"TriNetX, LLC, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Opening the Personal Gate between Technology and Health Care"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI260399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:03:54Z","timestamp":1779401034000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI260399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"ISBN":["9781643686615"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti260399","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}