{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:05:59Z","timestamp":1777392359458,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2018,3,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Sleep disturbances have been shown to be associated with the presence of the apolipoprotein ( APOE) \u025b4 allele, the well-known genetic risk factor for late-onset sporadic Alzheimer\u2019s disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study quantifies the effects of a six-month aerobic exercise intervention on objective and subjective sleep quality in middle-aged to older individuals including those at increased genetic risk for late-onset sporadic Alzheimer\u2019s disease (AD), who carry the apolipoprotein ( APOE) \u025b4 risk allele.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>199 sedentary men and women without significant cognitive impairments were enrolled in the Brain in Motion study, a quasi-experimental single group pre-test\/post-test study with no control group. Participants completed a six-month aerobic exercise intervention and consented to genetic testing. Genotyping of APOE confirmed that 54 individuals were carriers of the \u025b4 allele. Participants\u2019 subjective quality of sleep was assessed with the Pittsburgh Sleep Quality Index (PSQI) pre- and post-intervention. A convenience sample of participants ( n\u200a=\u200a29, APOE \u025b4+\u200a=\u200a7) consented to undergo two nights of in-home polysomnography (PSG) pre- and post intervention. Sleep architecture and respiratory variables were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The six-month aerobic exercise intervention significantly improved participants\u2019 total PSQI score, sleep efficiency, and sleep latency in the full sample ( n\u200a=\u200a199). PSG results showed that total sleep time and sleep onset latency significantly improved over the course of the exercise intervention only in individuals who carried the APOE \u025b4 allele. These results are, however, exploratory and need to be carefully interpreted due to the rather small number of APOE \u025b4+ in the PSG subgroup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The six-month aerobic exercise intervention significantly improved participants\u2019 sleep quality with beneficial effects on PSG shown in individuals at increased genetic risk for late-onset sporadic AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-180079","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T10:40:17Z","timestamp":1544784017000},"page":"229-238","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Six-Month Aerobic Exercise Intervention on Sleep in Healthy Older Adults in the\n                    <i>Brain in Motion<\/i>\n                    Study: A Pilot Study"],"prefix":"10.1177","volume":"2","author":[{"given":"Veronica","family":"Guadagni","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"O\u2019Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron M.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, 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S.","family":"Parboosingh","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Calgary, Calgary, AB, Canada"},{"name":"Alberta Children\u2019s Hospital Research Institute for Child and Maternal Health, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"O\u2019Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick 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Public Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,14]]},"reference":[{"key":"ref001","volume-title":"Prevalence and Monetary Costs of Dementia in Canada","author":"Alzheimer Society of 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