{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:09:20Z","timestamp":1790291360118,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2018,3,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cancer mortality and Alzheimer\u2019s disease (AD) mortality increase with age, but some studies have shown an inverse relationship of the two diseases, that is, older persons with cancer have a reduced risk of AD and vice versa. However, other analyses suggest that AD and brain tumor might be positively correlated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>In the current study, we wished to determine the relationship of AD mortality to malignant brain tumor mortality in US states and counties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data and maps of malignant brain tumor mortality and Alzheimer\u2019s disease mortality (1999\u20132016) are from the CDC Wonder tool (https:\/\/wonder.cdc.gov\/cmf-icd10.html). Data on malignant brain tumor types and their frequencies are from the Surveillance, Epidemiology, and End Results Program (SEER, https:\/\/seer.cancer.gov). Data on the genetics of lower grade glioma are from the TCGA Lower Grade Glioma (LGG) dataset in TCGA (The Cancer Genome Atlas).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>SEER data indicate that astrocytomas make up 58.2% of malignant brain tumors in patients 65 and older; glioblastoma and anaplastic astrocytoma make up 41.6%. We found a significant positive correlation between AD mortality rate and malignant brain tumor mortality rate 1999\u20132016 in persons age 65 and older in A) 1,101 US counties, p\u200a&lt; \u200a0.001 and B) 50 US states, p\u200a&lt; \u200a0.001.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Adult malignant brain tumors may share some environmental risks with AD. Malignant brain tumors and AD also have some genes in common: TREM2, SPI1, CD33, and INPP5D. The interaction of environment and genetics is complex and overlaps in malignant brain tumors and AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-180084","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T12:01:44Z","timestamp":1542369704000},"page":"213-218","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Glioma and Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"2","author":[{"given":"Steven","family":"Lehrer","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,11,16]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000152889.94785.51"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1038\/srep03467"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1159\/000341411"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e1442"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c91873"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829c5ec1"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2010.01.031"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-04930-7"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00697"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828726f5"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1136\/jamia.1994.95236162"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-016-0342-y"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170308"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-007-0032-4"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0184-x"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6221"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0197-5"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26049"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000183"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2938"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.84.5.819"}],"container-title":["Journal of Alzheimer's Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3233\/ADR-180084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/ADR-180084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/ADR-180084","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/ADR-180084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:56:39Z","timestamp":1777370199000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/ADR-180084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,6]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,3,6]]}},"alternative-id":["10.3233\/ADR-180084"],"URL":"https:\/\/doi.org\/10.3233\/adr-180084","relation":{},"ISSN":["2542-4823","2542-4823"],"issn-type":[{"value":"2542-4823","type":"print"},{"value":"2542-4823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,6]]}}}