{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:10:22Z","timestamp":1777392622569,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2021,3,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A 57-year-old right-handed man was admitted to the Treviso Memory Clinic due to the presence of memory forgetfulness, repetition of the same questions, episodes of confusion, initial difficulties in performing complex tasks and easy distraction over the past two years, as well as recurrent and never-happened-before car accidents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We report a peculiar case of an early onset Alzheimer\u2019s disease (AD) with an unusual symptomatology, apparently not fitting in any of the categorized atypical forms of AD nor being representative of a typical amnestic AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      The patient underwent a neuropsychological, structural, and metabolic cerebral evaluation by MRI and\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG PET, together with the search for cerebral amyloid (amyloid PET), a genetic testing for dementia related genes and the dosage of CSF protein biomarkers of neurodegenerative conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We observed a convergence of predominant frontal (dysexecutive, verbal disinhibition) and posterior (visuospatial) features of cognitive impairment. Structural MRI sequences showed subarachnoid spaces of the vault enlarged in the fronto-parietal region with anterior and posterior cortical atrophy. The hippocampus appeared preserved. The\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG PET scans showed hypometabolism in the prefrontal, lateral temporal, posterior parietal, and occipital regions bilaterally. The\n                      <jats:sup>18<\/jats:sup>\n                      F-Flutemetamol scan showed a diffused uptake of the amyloid tracer at the cerebral cortex. CSF biomarkers were compatible with Alzheimer\u2019s disease (AD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case report presented with clinical phenotypic aspects atypical of AD, both frontal and posterior, never described as concomitant in the most accredited criteria for atypical AD, and appeared therefore more atypical than each of the atypical AD phenotypes already reported.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-210009","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T05:44:48Z","timestamp":1736747088000},"page":"365-374","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["More Atypical than Atypical Alzheimer\u2019s Disease Phenotypes: A Treviso Dementia (TREDEM) Registry Case Report"],"prefix":"10.1177","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6329-3195","authenticated-orcid":false,"given":"Maurizio","family":"Gallucci","sequence":"first","affiliation":[{"name":"Cognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"},{"name":"Associazione Alzheimer Treviso Onlus, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Paola","family":"Mazzarolo","sequence":"additional","affiliation":[{"name":"Cognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Focella","sequence":"additional","affiliation":[{"name":"Cognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Berlin","sequence":"additional","affiliation":[{"name":"Cognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Fiore","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Di Paola","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Bendini","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Zanusso","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Fenoglio","sequence":"additional","affiliation":[{"name":"University of Milan, Dino Ferrari Center, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Galimberti","sequence":"additional","affiliation":[{"name":"University of Milan, Dino Ferrari Center, Milan, Italy"},{"name":"Fondazione IRCCS Ca\u2019 Granda, Ospedale Policlinico, Neurodegenerative Disease Unit, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Bonanni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Imaging and Clinical Sciences and CESI, University G D\u2019Annunzio of Chieti-Pescara, Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70223-4"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.004"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70090-0"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.3.484"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-005-0443-4"},{"key":"ref007","unstructured":"MondiniS, MapelliD, VestriA, ArcaraG, BisiacchiPS (2011)\n                      Esame Neuropsicologico Breve 2. 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