{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:52:25Z","timestamp":1778712745593,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2022,12,16]]},"abstract":"<jats:p>\u00a0Presuming that Alzheimer\u2019s disease (AD) might represent an antagonistic pleiotropic phenomenon derived from the evolvability of multiple amyloidogenic proteins, targeting such proteins simultaneously could enhance therapeutic efficacy. Furthermore, considering that amyloid-\u03b2 (A\u03b2) immunotherapies during reproductive life stage might adversely decrease A\u03b2 evolvability in an offspring\u2019s brain, the disease-modifying A\u03b2 immunotherapies should be limited to post-reproductive time in lifespan. Thus, current A\u03b2 immunotherapy strategies should be revised accordingly. Given that the \u201cadiponectin paradox\u201d might underlie both amyloidosis and cognitive dysfunction in aging brain, blocking activin signaling situated downstream of the adiponectin paradox might be an alternative strategy to prevent AD.<\/jats:p>","DOI":"10.3233\/adr-210021","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T11:23:48Z","timestamp":1650626628000},"page":"207-210","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Reconsideration of Alzheimer\u2019s Disease Therapy from a Viewpoint of Amyloidogenic Evolvability"],"prefix":"10.1177","volume":"6","author":[{"given":"Gilbert","family":"Ho","sequence":"first","affiliation":[{"name":"PCND Neuroscience Research Institute, Poway, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei Chen","family":"Choo","sequence":"additional","affiliation":[{"name":"PCND Neuroscience Research Institute, Poway, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Waragai","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan"},{"name":"Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliezer","family":"Masliah","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, National Institute on Aging, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,4,22]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000073623.84147.A8"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq056"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61075-2"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25410"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170894"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.15.8420"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2016.10.015"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-181365"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0013-z"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2016.1120"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23956"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.2174\/1567205013666160229112725"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1002\/alz.041129"},{"key":"ref015","unstructured":"U.S. Food and Drug Administration (2021) FDA Grants Accelerated Approval for Alzheimer\u2019s Drug. Silver Spring, MD https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-grants-accelerated-approval-alzheimers-drug"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180986"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020289"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021881"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1038\/nm1781"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12086"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00108"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200416"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210206"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1126\/science.2106159"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.248195"},{"key":"ref026","first-page":"14","volume":"27","author":"Tsuchida K","year":"2008","journal-title":"Acta Myol"}],"container-title":["Journal of Alzheimer's Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/ADR-210021","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/ADR-210021","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/ADR-210021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:57:11Z","timestamp":1777370231000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/ADR-210021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,22]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12,16]]}},"alternative-id":["10.3233\/ADR-210021"],"URL":"https:\/\/doi.org\/10.3233\/adr-210021","relation":{},"ISSN":["2542-4823","2542-4823"],"issn-type":[{"value":"2542-4823","type":"print"},{"value":"2542-4823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,22]]}}}