{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:08:28Z","timestamp":1777392508330,"version":"3.51.4"},"reference-count":108,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2021,3,11]]},"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a neurodegenerative disease that is coupled with chronic cognitive dysfunction. AD cases are mostly late onset, and genetic risk factors like the Apolipoprotein E ( APOE) play a key role in this process. APOE \u025b2, APOE \u025b3, and APOE \u025b4 are three key alleles in the human APOE gene. For late onset, APOE \u025b4 has the most potent risk factor while APOE \u025b2 plays a defensive role. Several studies suggests that APOE \u025b4 causes AD via different processes like neurofibrillary tangle formation by amyloid-\u03b2 accumulation, exacerbated neuroinflammation, cerebrovascular disease, and synaptic loss. But the pathway is still unclear that which actions of APOE \u025b4 lead to AD development. Since APOE was found to contribute to many AD pathways, targeting APOE \u025b4 can lead to a hopeful plan of action in development of new drugs to target AD. In this review, we focus on recent studies and perspectives, focusing on APOE \u025b4 as a key molecule in therapeutic strategies.<\/jats:p>","DOI":"10.3233\/adr-210027","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T12:03:13Z","timestamp":1640088193000},"page":"899-910","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Perspectives on the Role of\n                    <i>APOE4<\/i>\n                    as a Therapeutic Target for Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"5","author":[{"given":"Kavita","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siwangi","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Motilal Nehru 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