{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:46:32Z","timestamp":1790531192721,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2021,3,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Therapeutic research into Alzheimer\u2019s disease (AD) has been dominated by the amyloid cascade hypothesis (ACH) since the 1990s. However, targeting amyloid in AD patients has not yet resulted in highly significant disease-modifying effects. Furthermore, other promising theories of AD etiology exist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We sought to directly investigate whether the ACH still dominates the opinions of researchers working on AD and explore the implications of this question for future directions of research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>During 2019, we undertook an international survey promoted with the help of the Alzheimer\u2019s Association with questions on theories and treatments of AD. Further efforts to promote a similar study in 2021 did not recruit a significant number of participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>173 researchers took part in the 2019 survey, 22% of which held \u201cpro-ACH\u201d opinions, tended to have more publications, were more likely to be male, and over 60. Thus, pro-ACH may now be a minority opinion in the field but is nevertheless the hypothesis on which the most clinical trials are based, suggestive of a representation bias. Popular vote of all 173 participants suggested that lifestyle treatments and anti-tau drugs were a source of more therapeutic optimism than anti-amyloid treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We propose a more democratic research structure which increases the likelihood that promising theories are published and funded fairly, promotes a broader scientific view of AD, and reduces the larger community\u2019s dependence on a fragile economic model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-210030","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T13:08:33Z","timestamp":1627391313000},"page":"637-645","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["A Proposal to Make Biomedical Research into Alzheimer\u2019s Disease More Democratic Following an International Survey with Researchers"],"prefix":"10.1177","volume":"5","author":[{"given":"Timothy","family":"Daly","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, Science Norms Democracy, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Houot","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France"},{"name":"AP-HP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Institute of Memory and Alzheimer\u2019s Disease, Centre of Excellence of Neurodegenerative Disease (CoEN), National Reference Centre for Rare and Early Dementias, Department of Neurology, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Barberousse","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Science Norms Democracy, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Petit","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Saclay, Inserm, CESP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Epelbaum","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France"},{"name":"AP-HP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Institute of Memory and Alzheimer\u2019s Disease, Centre of Excellence of Neurodegenerative Disease (CoEN), National Reference Centre for Rare and Early Dementias, Department of Neurology, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-019-0063-8"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12192"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160152"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12192"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1007\/s10670-009-9194-6"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)02031-2"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1046"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1418218112"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1038\/492034a"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2009.00117.x"},{"key":"ref011","unstructured":"TanziR. \u2018New clarity\u2019 against Alzheimer\u2019s. 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