{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:21:40Z","timestamp":1793863300812,"version":"4.6.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2021,3,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Guidelines worldwide recommend restricted prescription of benzodiazepine receptor agonists (BZRAs), i.e., benzodiazepines and Z-drugs, for the treatment of dementia-associated behavioral and psychological symptoms and insomnia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the prevalence and appropriateness of BZRA use among nursing home residents with dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a post-hoc analysis of BZRA prescriptions from two intervention studies on psychotropic drug use, conducted from 2016 to 2018. It includes 1,111 residents of dementia special care units from 24 Dutch long-term care organizations. We assessed the prevalence of use of continuous and as-needed BZRA prescriptions and their association with registered symptoms. Continuous BZRA prescriptions were evaluated for appropriateness, i.e., whether indication, dosage, duration, and evaluation accorded with guidelines for the treatment of challenging behavior in dementia and sleep disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The prevalence of BZRA use is 39.2% (95% CI: 36.3%\u201342.0%): continuous 22.9%; only as-needed 16.3%. Combinations of preferred BZRAs and appropriate indications occur in 19.0% of continuous anxiolytic prescriptions and 44.8% of hypnotic prescriptions. Frequently registered inappropriate indications are aggression\/agitation for anxiolytics (continuous: 75.7%; as-needed: 75.2%) and nighttime agitation for hypnotics (continuous: 40.3%; as-needed: 26.7%). None of the continuous prescriptions with appropriate indications were appropriate for all other items. For most of the prescriptions, duration and time to evaluation exceeded 4 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>BZRA use in nursing home residents with dementia is highly frequent. A large proportion of prescriptions do not follow the guidelines with regard to indication, exceed the recommended duration and are not evaluated in a timely manner. The discrepancy between evidence-based guidelines and daily practice calls for an exploration of factors maintaining inappropriate use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-210041","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T10:51:08Z","timestamp":1638528668000},"page":"871-879","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Use of Benzodiazepines and Z-Drugs in Nursing Home Residents with Dementia:           Prevalence and Appropriateness"],"prefix":"10.1177","volume":"5","author":[{"given":"Dirk O.C.","family":"Rijksen","sequence":"first","affiliation":[{"name":"Carintreggeland, Center for Specialized Geriatric Care, Hengelo, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sytse U.","family":"Zuidema","sequence":"additional","affiliation":[{"name":"Department of General Practice and Elderly Care Medicine,\r            University of Groningen, University Medical Center Groningen,\r          Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther C.","family":"de Haas","sequence":"additional","affiliation":[{"name":"Department of General Practice and Elderly Care Medicine,\r            University of Groningen, University Medical Center Groningen,\r          Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2012.09.027"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2232"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2015.07.001"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-016-2058-5"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00365-7"},{"key":"ref006","first-page":"pyv055","volume":"18","author":"Defrancesco M","year":"2015","journal-title":"Neuropsychopharmacol"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1177\/1533317514524813"},{"key":"ref008","first-page":"CD009178","volume":"11","author":"McCleery J","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7020017"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15767"},{"key":"ref011","unstructured":"National Collaborating Centre for Mental Health commisioned by the Social Care\n            Institute for Excellence, National Institute for Health and Clinical Excellence\n            (2007) A NICE-SCIE guideline on supporting people with dementia and their\n          carers in health and social care (National Clinical Practice Guideline Number 42),\n            The British Psychological Society and The Royal College of\n            Psychiatrists,\n          Leicester\/London."},{"key":"ref012","unstructured":"Canadian Coalition for Seniors\u2019 Mental Health (2006) National guidelines\n          for seniors\u2019 mental health: The assessment and treatment of mental health issues in\n          long-term care homes (focus on mood and behaviour symptoms), Canadian Coalition for\n          Seniors\u2019 Mental Health, Toronto."},{"issue":"12","key":"ref013","first-page":"5","volume":"164","author":"APA Work Group on Alzheimer\u2019s Disease and other Dementias","year":"2007","journal-title":"Am J Psychiatry"},{"key":"ref014","unstructured":"National Health and Medical Research Council (2016) Clinical practice\n          guidelines and principles of care for people with dementia, NHMRC Partnership Centre for\n          Dealing with Cognitive and Related Functional Decline in Older People,\n          Sydney."},{"key":"ref015","unstructured":"ZuidemaSU, SmalbruggeM, BilWME,             GeelenR, KokRM,             LuijendijkHJ,             van der\n              SteltI, van\n            StrienAM, VinkMT,             VreekenHL             (2018) Multidisciplinary Guideline problem behaviour in             dementia, Verenso & NIP,             Utrecht."},{"key":"ref016","unstructured":"National Clinical Effectiveness Committee (2019) Appropriate prescribing\n          of psychotropic medication for non-cognitive symptoms in people with dementia (NCEC\n          National Clinical Guideline No. 21), The Department of Health, Dublin."},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-019-2291-4"},{"key":"ref018","unstructured":"GorgelsW, Knuistingh\n            NevenA, LucassenPLBJ, SmeltA,             Damen-van\n              BeekZ, BoumaM,             VerduijnMM, Van\n            VenrooijM (2014) The Dutch College of           General Practitioners\u2019 (NHG) guideline Sleep problems and sleeping pills, The Dutch           College of General Practitioners, Utrecht."},{"key":"ref019","unstructured":"Dutch National Health Care Institute (Zorginstituut Nederland):\n          Farmacotherapeutisch Kompas. https:\/\/farmacotherapeutischkompas.nl, Accessed on March 10,\n          2021."},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610209008916"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2017.1348469"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1177\/0091270011405665"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1177\/0004867418758919"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.04.033"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16751"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-019-00883-7"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1177\/1533317515585924"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.07.004"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1017\/S104161021600082X"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-018-0544-4"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2257-8"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afn135"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e1093"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.00857"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15855"}],"container-title":["Journal 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